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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves beta-Cell Function Under Stress [作者：Gurevitch, D; Boura-Halfon, S; Isaac, R; Shahaf, G; Alberstein, M; Ronen, D; Lewis, EC; Zick, Y,期刊：Diabetes, 页码：2188-2197 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-Cellular stress and proinflammatory cytokines induce phosphorylation of insulin receptor substrate (IRS) proteins at Ser sites that inhibit insulin and IGF-1 signaling. Here, we examined the role of Ser phospho... Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in alpha-Cells Inhibits Glucagon Secretion From Human Islets [作者：Ramracheya, R; Ward, C; Shigeto, M; Walker, JN; Amisten, S; Zhang, QA; Johnson, PR; Rorsman, P; Braun, M,期刊：Diabetes, 页码：2198-2208 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-To document the properties of the voltage-gated ion channels in human pancreatic alpha-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS-Glucagon release was measured from intact islets. [Ca... Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic beta-Cell Function [作者：Robert-Cooperman, CE; Carnegie, JR; Wilson, CG; Yang, JC; Cook, JR; Wu, JM; Young, RA; Wolf, BA; Burkhardt, BR,期刊：Diabetes, 页码：2209-2218 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-Pancreatic-derived factor (PANDER, FAM3B) is a pancreatic islet-specific cytokine-like protein that is secreted from beta-cells upon glucose stimulation. The biological function of PANDER is unknown, and to add... Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes [作者：Zhang, CY; Wang, MA; Racine, JJ; Liu, HJ; Lin, CL; Nair, I; Lau, J; Cao, YA; Todorov, I; Atkinson, M; Zeng, DF,期刊：Diabetes, 页码：2228-2236 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-To test whether induction of chimerism lowers the amount of donor islets required for reversal of diabetes and renders the pancreas a suitable site for islet grafts in autoimmune diabetic mice. RESEARCH DESIGN ... Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islet Allograft [作者：Jalili, RB; Forouzandeh, F; Rezakhanlou, AM; Hartwell, R; Medina, A; Warnock, GL; Larijani, B; Ghahary, A,期刊：Diabetes, 页码：2219-2227 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-The requirement of systemic immunosuppression after islet transplantation is of significant concern and a major drawback to clinical islet transplantation. Here, we introduce a novel composite three-dimensional... Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin [作者：Lin, M; Yin, N; Murphy, B; Medof, ME; Segerer, S; Heeger, PS; Schroppel, B,期刊：Diabetes, 页码：2247-2252 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-The complement system contributes to autoimmune injury, but its involvement in promoting the development of autoimmune diabetes is unknown. In this study, our goal was to ascertain the role of complement C3 in ... Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change [作者：Alam, C; Valkonen, S; Palagani, V; Jalava, J; Eerola, E; Hanninen, A,期刊：Diabetes, 页码：2237-2246 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-Dietary factors influence diabetes development in the NOD mouse. Diet affects the composition of microbiota in the distal intestine, which may subsequently influence intestinal immune homeostasis. However, the ... Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2r gamma(null) Ins2(Akita) Mice [作者：Brehm, MA; Bortell, R; diIorio, P; Leif, J; Laning, J; Cuthbert, A; Yang, CX; Herlihy, M; Burzenski, L; Gott, B; Foreman, O; Powers, AC; Greiner, DL; Shultz, LD,期刊：Diabetes, 页码：2265-2270 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell-derived beta-cells in the absence or presence of a functional human ... A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice [作者：Vergani, A; D'Addio, F; Jurewicz, M; Petrelli, A; Watanabe, T; Liu, KF; Law, K; Schuetz, C; Carvello, M; Orsenigo, E; Deng, SP; Rodig, SJ; Ansari, JM; Staudacher, C; Abdi, R; Williams, J; Markmann, J; Atkinson, M; Sayegh, MH; Fiorina, P,期刊：Diabetes, 页码：2253-2264 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-To investigate a new clinically relevant immunoregulatory strategy based on treatment with murine Thymoglobulin mATG Genzyme and CTLA4-Ig in NOD mice to prevent allo- and autoimmune activation using a stringent... Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia [作者：Diggs-Andrews, KA; Zhang, XZ; Song, ZT; Daphna-Iken, D; Routh, VH; Fisher, SJ,期刊：Diabetes, 页码：2271-2280 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-An impaired ability to sense and appropriately respond to insulin-induced hypoglycemia is a common and serious complication faced by insulin-treated diabetic patients. This study tests the hypothesis that insul... Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis [作者：Kursawe, R; Eszlinger, M; Narayan, D; Liu, T; Bazuine, M; Cali, AMG; D'Adamo, E; Shaw, M; Pierpont, B; Shulman, GI; Cushman, SW; Sherman, A; Capriol, S,期刊：Diabetes, 页码：2288-2296 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE We explored whether the distribution of adipose cell size, the estimated total number of adipose cells, and the expression of adipogenic genes in subcutaneous adipose tissue are linked to the phenotype of high ... Age-Period-Cohort Analysis of 1990-2003 Incidence Time Trends of Childhood Diabetes in Italy The RIDI Study [作者：Bruno, G; Maule, M; Merletti, F; Novelli, G; Falorni, A; Iannilli, A; Iughetti, L; Altobelli, E; d'Annunzio, G; Piffer, S; Pozzilli, P; Iafusco, D; Songini, M; Roncarolo, F; Toni, S; Carle, F; Cherubini, V,期刊：Diabetes, 页码：2281-2287 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-To investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0-14 years in Italian registries. RESEARCH DESIGN AND METHODS-This report is based on 5,180 incident cases in th... The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing [作者：Fadini, GP; Albiero, M; Menegazzo, L; Boscaro, E; Pagnin, E; Iori, E; Cosma, C; Lapolla, A; Pengo, V; Stendardo, M; Agostini, C; Pelicci, PG; Giorgio, M; Avogaro, A,期刊：Diabetes, 页码：2306-2314 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-The redox enzyme p66Shc produces hydrogen peroxide and triggers proapoptotic signals. Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the ... Muller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage [作者：Wang, JJ; Xu, XL; Elliott, MH; Zhu, ML; Le, YZ,期刊：Diabetes, 页码：2297-2305 , 文章类型： Article，,卷期：2010年59-9] OBJECTIVE-Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic factor and therapeutic target for diabetic retinopathy (DR). Since VEGF has been proposed as a survival factor for retinal neurons, defi...