- AMP-activated Protein Kinase alpha 2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
[作者:Jelenik, T; Rossmeisl, M; Kuda, O; Jilkova, ZM; Medrikova, D; Kus, V; Hensler, M; Janovska, P; Miksik, I; Baranowski, M; Gorski, J; Hebrard, S; Jensen, TE; Flachs, P; Hawley, S; Viollet, B; Kopecky, J,期刊:Diabetes, 页码:2737-2746 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE-The induction of obesity, dyslipidemia, and insulin resistance by high-fat diet in rodents can be prevented by n-3 long-chain polyunsaturated fatty acids (LC-PUFAs). We tested a hypothesis whether AMP-activated...
- Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults
[作者:Timmerman, KL; Lee, JL; Fujita, S; Dhanani, S; Dreyer, HC; Fry, CS; Drummond, MJ; Sheffield-Moore, M; Rasmussen, BB; Volpi, E,期刊:Diabetes, 页码:2764-2771 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE-Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy, nondiabetic older adults. This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling....
- Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes The Edinburgh Type 2 Diabetes Study
[作者:Ding, J; Strachan, MWJ; Reynolds, RM; Frier, BM; Deary, IJ; Fowkes, FGR; Lee, AJ; McKnight, J; Halpin, P; Swa, K; Price, JF,期刊:Diabetes, 页码:2883-2889 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE-Cerebral microvascular disease associated with type 2 diabetes may exacerbate the effects of aging on cognitive function. A considerable homology exists between the retinal and cerebral microcirculations; a hyp...
- Enhanced Levels of microRNA-125b in Vascular Smooth Muscle Cells of Diabetic db/db Mice Lead to Increased Inflammatory Gene Expression by Targeting the Histone Methyltransferase Suv39h1
[作者:Villeneuve, LM; Kato, M; Reddy, MA; Wang, M; Lanting, L; Natarajan, R,期刊:Diabetes, 页码:2904-2915 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE Diabetes remains a major risk factor for vascular complications that seem to persist even after achieving glycemic control, possibly due to "metabolic memory." Using cultured vascular smooth muscle cells (MVSMC...
- Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
[作者:Wang, XXX; Jiang, T; Shen, Y; Caldas, Y; Miyazaki-Anzai, S; Santamaria, H; Urbanek, C; Solis, N; Scherzer, P; Lewis, L; Gonzalez, FJ; Adorini, L; Pruzanski, M; Kopp, JB; Verlander, JW; Levi, M,期刊:Diabetes, 页码:2916-2927 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE The pathogenesis of diabetic nephropathy is complex and involves activation of multiple pathways leading to kidney damage. An important role for altered lipid metabolism via sterol regulatory element binding pr...
- Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
[作者:Xu, WL; Caracciolo, B; Wang, HX; Winblad, B; Backman, L; Qiu, CX; Fratiglioni, L,期刊:Diabetes, 页码:2928-2935 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE-The effect of diabetes on mild cognitive impairment (MCI) and its conversion to dementia remains controversial. We sought to examine whether diabetes and pre-diabetes are associated with MCI and accelerate the ...
- Combined Effect of Inflammatory Gene Polymorphisms and the Risk of Ischemic Stroke in a Prospective Cohort of Subjects With Type 2 Diabetes: A Go-DARTS Study
[作者:Palmer, CNA; Kimber, CH; Doney, ASF; Proia, AS; Morris, AD; Gaetani, E; Quarta, M; Smith, RC; Pola, R,期刊:Diabetes, 页码:2945-2948 , 文章类型: Article,,卷期:2010年59-11]
- OBJECTIVE-We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of ge...
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