N-Sulfinyl amines have been successfully employed as nitrogen nucleophiles for the asymmetric intramolecular aza-Michael reaction. The synthetic strategy involves a cross-metathesis reaction followed by the Michael-type ...
Different diyne-diols composed of two terminal homopropargylic alcohol groups were prepared by bi-directional synthesis Subjection of the syn diastereomers to NAC gold catalysts (NAC=nitrogen acyclic carbene) in the pres...
A novel family of dumbbell-shaped dinuclear complexes in which an oligophenyleneethynylene spacer is linked to two heteroleptic iridium(III) complexes is presented. The synthesis. as well as the electrochemical and photo...
A procedure for the synthesis of functionalized. substituted pyrroles by 1.3-dipolar cycloaddition of azomethine ylides has been developed This protocol is based on the metal-catalyzed cycloaddition of alpha-iminoesters ...
Aziridination of (R)-N-sulfinylaldimines (aryl, heteroaryl and alkenyl derivatives) with 2-(p-tolyl sulfinyl)benzyl iodide in the presence of sodium hexamethyl disilazide takes place with almost complete control of the s...
The first highly diastereo- and enantioselective organocatalytic synthesis of 2.2-disubstituted-2H-oxazol-5-ones is described The addition of oxazolones to maleimides is promoted by bifunctional thiourea catalysts, which...
The copper-catalyzed conjugate addition of Grignard reagents to 3-substituted cyclic enones allows the formation of all-carbon chiral quaternary centers We demonstrate in this article that N-heterocyclic carbencs act as ...
The palladium-catalyzed cross-coupling reaction of organogold(I) re-agents (alkyl, alkenyl. aryl. and alkynyl) with organic electrophiles. such as aryl and alkenyl halides. aryl inflates. benzyl bromide, and benzoyl chlo...
The diastereofacial selection in addition reactions to biased rigid systems can be modulated by the action of Lewis acids As an example. the stereoselectivity of the nucleophilic addition of vinyl magnesium bromide (VMB)...
Saframycins. safracins. renieiamycins, cribiostatins. and esteinascidins ale 6.15-iminoisoquino[3.2-b]3-benzazocine compounds that constitute the largest subgroup among the antitumor antibiotics belonging to the tetrahyd...