Baylis-Hillman alcohols derived from methylacrylate or acrylonitrile and carrying an N-Boe group beta to the hydroxyl (CH(OH)CHNBoc) can be converted into unusual seven-membered hetrocyeles containing both nitrogen and s...
Naturally occuring phenanthiondolizidine alkaloids (R)-antofine and phenanthloquinolizidine alkaloids (R)-crypto pleurine have been synthesized in high optical purity via proline-catalyzed sequential alpha-aminoxylation ...
A mild simple safe chemoselective reduction of different kinds to the corresponding alcohols mediated by the Mn dust/water system is described. In addition to this, the use of D2O leads to the synthesis of alpha-deuerate...
The total synthesis of the bridge-used Aspidosperma indole alkaloid (+/-)-subincanadine has been accomplished in seven steps The synthetic utility of a titanium mediated intramolecular nucleophilic acyl substitution (INA...
The total synthesis of (+)-demethoxycardmalm 3 is described The synthetic strategy features the synthesis of dimerie Fischer carbene and us use in a biduectional Doi/ benzamulation reaction to set the dimerie structure o...
A mild, efficient and simple method for the synthesis of 3-ethoxycarbonylindoles had been developed. Addition of ethyl diazoacetate (EDA) to 2-aminobenadehydes cleanly affords the indole core. As opposed to other common ...
Copper-catalyzed double thiolation reaction of 1.4-dihildes with sulfides has been developed for selectively synthesizing 2-trifluoromethyl benzothmphenes and benzothitizoles In the presence of CuI, a variety of 2-halo-1...
Bacteria use small molecule signals to access then local population densities in a process called quorum sensing (QS) Once a threshold signal concentration is reached, and therefore a certain number of bacteria have asse...
A catalyst was synthesized on the basis of Trost's dinuclear catalyst characterized by working well without pyridine in the present phospha-Michael reaction Nevertheless, the presence of pyridine is still advantageous in...
The quantification of factors that influence both rates and stereoselectivity of anomerization reactions catalyzed by SnCl4 and TiCl4 and how this has informed the synthesis of alpha-O- and alpha-S-glycolipids is discuss...
We have developed a useful modification of the classical preparation of phenanthienes by UV irradiation of stildbenes in the presence of an oxidant This modification involves the irradiation. in the presence of base, of ...
The efficient synthesis and photophysical propel ties of a series of ambipolar donor acceptor donor Systems is described where the acceptor is dibenzothrophene S,S-dioxide and the donor is fluorene, carbazole or arylamin...
This computational study provoked by the process of peptide bond formation in the ribosome investigates the influence of the vicinal OH group in monoacylated diols on the elementary acts of ester aminolysis Two alternati...
Six- and seven-membered cyclic enaminones can be prepared using common. environmentally benign reagents. Ammo acids are used as synthetic precursors allowing diversification and the incorporation of chirality The key rea...
Novel lipid derivatives carrying amino and triazolyl groups were efficiently synthesized and covalently anchored at the 3'-termini of oligonucleondes The desired amino-lipid conjugates were fully characterized by reverse...
The synthesis of the polymerizable fluorinated surfactant sodium 1,1,2 2-tetrafluoro-2-(1,1 2 2-tetrafluoro-2-(4-vinylphenyl)ethoxy)ethanesulfonate (I) and a number or dated fluorocarbon compounds is described Compound I...