- Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies
[作者:Abbas, SE; Awadallah, FM; Ibrahim, NA; Gouda, AM,期刊:European Journal of Medicinal Chemistry, 页码:482-491 , 文章类型: Article,,卷期:2010年45-2]
- Synthesis of several substituted pyrrolizines 10a-f, 11a-f, 13a-c, pyrimidopyrrolizines 14a-c, 15a-c, and pyrrolizinopyrimidoisoindoles 12a-c was discussed. The starting compounds 6-amino-7-cyano-N-(4-(un)substitutedphen...
- Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives
[作者:Farghaly, TA; Hafez, NAA; Ragab, EA; Awad, HM; Abdalla, MM,期刊:European Journal of Medicinal Chemistry, 页码:492-500 , 文章类型: Article,,卷期:2010年45-2]
- Reaction of benzosuberone 1 with dimethylformamide-dimethylacetal (DMF-DMA) gives 2-dimethylamino-methylenebenozosuberone 2 which in turn reacts with heterocyclic amines to furnish new heterocyclic ring systems 6-9. More...
- Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors
[作者:Yi, W; Cao, RH; Peng, WL; Wen, H; Yan, Q; Zhou, BH; Ma, L; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:639-646 , 文章类型: Article,,卷期:2010年45-2]
- A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory ...
- Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents
[作者:Bakavoli, M; Bagherzadeh, G; Vaseghifar, M; Shiri, A; Pordel, M; Mashreghi, M; Pordeli, P; Araghi, M,期刊:European Journal of Medicinal Chemistry, 页码:647-650 , 文章类型: Article,,卷期:2010年45-2]
- Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to...
- Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
[作者:Bharti, SK; Nath, G; Tilak, R; Singh, SK,期刊:European Journal of Medicinal Chemistry, 页码:651-660 , 文章类型: Article,,卷期:2010年45-2]
- A series of arylidene-2-(4-(4-methoxy/bromophenyl) thiazol-2-yl) hydrazines (4a-z) and 1-(4-(4-methoxy/bromophenyl) thiazol-2-yl)-2-cyclohexylidene/cyclopentylidene hydrazines (5a-b/6a-b) were synthesized, characterized ...
- Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents
[作者:Kumar, A; Maurya, RA; Sharma, S; Kumar, M; Bhatia, G,期刊:European Journal of Medicinal Chemistry, 页码:501-509 , 文章类型: Article,,卷期:2010年45-2]
- N-aryl-1,4-dihydropyridines 2a-n were synthesized via iodine catalyzed three-component reaction of cinnamaldehydes, anilines and 2-keto esters in methanol. The synthesized compounds were screened for their antidyslipidem...
- Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents
[作者:Solankee, A; Kapadia, K; Ciric, A; Sokovic, M; Doytchinova, I; Geronikaki, A,期刊:European Journal of Medicinal Chemistry, 页码:510-518 , 文章类型: Article,,卷期:2010年45-2]
- Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2,4-bis-(phenylamino)-6-[4'-{3 ''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2 ''-propenon-1 ''-yl}phenylamino]-s-thriazines 6a-e....
- Anticancer activity of dinuclear gallium(III) carboxylate complexes
[作者:Kaluderovic, MR; Gomez-Ruiz, S; Gallego, B; Hey-Hawkins, E; Paschke, R; Kaluderovic, GN,期刊:European Journal of Medicinal Chemistry, 页码:519-525 , 文章类型: Article,,卷期:2010年45-2]
- The reaction of 3-methoxyphenylacetic acid, 4-methoxyphenylacetic acid, mesitylthioacetic acid, 2,5-dimethyl-3-furoic acid and 1,4-benzodioxane-6-carboxylic acid with trimethylgallium (1:1) yielded the dimeric complexes ...
- Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones
[作者:Pisoni, DD; da Costa, JS; Gamba, D; Petzhold, CL; Borges, ACD; Ceschi, MA; Lunardi, P; Goncalves, CAS,期刊:European Journal of Medicinal Chemistry, 页码:526-535 , 文章类型: Article,,卷期:2010年45-2]
- This work describes the enantioselective synthesis of a new series of terpenic chiral 9-aminotetrahydroacridine analogues. Several chiral ketones were synthesized from natural monoterpenes in an optically active form and...
- 3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods
[作者:Pan, XL; Tan, NH; Zeng, GZ; Huang, HQ; Yan, H,期刊:European Journal of Medicinal Chemistry, 页码:667-681 , 文章类型: Article,,卷期:2010年45-2]
- Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on 64 ketoamides as human cathepsin K (CatK) inhibitors, using ROCS ligand-based alignment and re...
- A microwave-assisted, facile, regioselective Friedlander synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2-b]quinolines
[作者:Balamurugan, K; Jeyachandran, V; Perumal, S; Manjashetty, TH; Yogeeswari, P; Sriram, D,期刊:European Journal of Medicinal Chemistry, 页码:682-688 , 文章类型: Article,,卷期:2010年45-2]
- A series of 2,9-diaryl-2,3-dihydrothieno[3,2-b]quinolines have been synthesized regioselectively by Friedlander annulation of 5-aryldihydro-3(2H)-thiophenones and 2-aminobenzophenones in the presence of trifluoroacetic a...
- Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: Molecular modeling applications
[作者:El-Sherbeny, MA; Abdel-Aziz, AAM; Ahmed, MA,期刊:European Journal of Medicinal Chemistry, 页码:689-697 , 文章类型: Article,,卷期:2010年45-2]
- Some new ethyl 2-[3-(4-unsubstituted or 4-substituted phenylsufonyl)ureido]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylates 3a-c, 2-[3-(phenylsulfonyl)ureido]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-ca...
- P2 '-truncated BACE-1 inhibitors with a novel hydroxethylene-like core
[作者:Meredith, JA; Bjorklund, C; Adolfsson, H; Jansson, K; Hallberg, A; Rosenquist, A; Samuelsson, B,期刊:European Journal of Medicinal Chemistry, 页码:542-554 , 文章类型: Article,,卷期:2010年45-2]
- Highly potent BACE-1 protease inhibitors derived from a novel hydroxyethylene-like core structure were recently developed by our group using X-ray crystal structure data and molecular modelling. In a continuation of this...
- Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives
[作者:Sondhi, SM; Singh, J; Rani, R; Gupta, PP; Agrawal, SK; Saxena, AK,期刊:European Journal of Medicinal Chemistry, 页码:555-563 , 文章类型: Article,,卷期:2010年45-2]
- Condensation of 9-chloro-2,4-(un)substituted acridines (la-c) with various amines (2a-e) and 9-isothiocyanato-2,4-(un)substituted acridines (4a,b) with different amines (2a,b,d,e) gave condensed products 3a-o and 5a-g re...
|