- Synthesis, characterization and structure-activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones
[作者:Makarov, MV; Leonova, ES; Rybalkina, EY; Tongwa, P; Khrustalev, VN; Timofeeva, TV; Odinets, IL,期刊:European Journal of Medicinal Chemistry, 页码:992-1000 , 文章类型: Article,,卷期:2010年45-3]
- In order to design the agents with improved antitumor activity of 3,5-bis(thienylidene)piperid-4-one type, E,E-N-phosphoryl-3,5-bis(thienylidene)piperid-4-ones 6a-c and E,E-N-omega-phosphorylalkyl-3,5-bis-(thienylidene)p...
- Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy
[作者:Frackowiak, A; Skibinski, P; Gawel, W; Zaczynska, E; Czarny, A; Gancarz, R,期刊:European Journal of Medicinal Chemistry, 页码:1001-1007 , 文章类型: Article,,卷期:2010年45-3]
- Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as sub...
- Docking and 3D-QSAR studies of influenza neuraminidase inhibitors using three-dimensional holographic vector of atomic interaction field analysis
[作者:Sun, JY; Cai, SX; Yan, N; Mei, H,期刊:European Journal of Medicinal Chemistry, 页码:1008-1014 , 文章类型: Article,,卷期:2010年45-3]
- Surflex-Dock is employed to investigate interactions between neuraminidase inhibitors (NIs) and neuraminidase (NA), which illuminate that carboxyl group, amino (guanidino) group, amide group, hydroxy group are crucial. H...
- A theoretical study of the structure-radical scavenging activity of trans-resveratrol analogues and cis-resveratrol in gas phase and water environment
[作者:Mikulski, D; Gorniak, R; Molski, M,期刊:European Journal of Medicinal Chemistry, 页码:1015-1027 , 文章类型: Article,,卷期:2010年45-3]
- Quantum calculations based on the density functional theory (DFT) have been employed to study the relation between the structure and antioxidant activity of trans-resveratrol (TR), cis-resveratrol (CR), trans-4,4'-dihydr...
- New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro
[作者:Gao, EJ; Zhu, MC; Huang, Y; Liu, L; Liu, HY; Liu, FC; Ma, S; Shi, CY,期刊:European Journal of Medicinal Chemistry, 页码:1034-1041 , 文章类型: Article,,卷期:2010年45-3]
- Two novel complexes, namely, [Pd(pdc)(2)]center dot(dmp)center dot 6H(2)O (1) and [Pd(pdc)(2)K(H2O)(5)center dot 3H(2)O]n (2) [H(2)pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesiz...
- New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity
[作者:Riyadh, SM; Farghaly, TA; Abdallah, MA; Abdalla, MM; Abd El-Aziz, MR,期刊:European Journal of Medicinal Chemistry, 页码:1042-1050 , 文章类型: Article,,卷期:2010年45-3]
- Three series of novel pyrazole derivatives 2b-d, 4a-d and 6a-d were synthesized via two step procedure that utilizes hydrazonoyl chlorides 1a-d and enaminones 3a-d and 5a-d, respectively as starting materials. The struct...
- Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
[作者:Grguric-Sipka, S; Ivanovic, I; Rakic, G; Todorovic, N; Gligorijevic, N; Radulovic, S; Arion, VB; Keppler, BK; Tesic, ZL,期刊:European Journal of Medicinal Chemistry, 页码:1051-1058 , 文章类型: Article,,卷期:2010年45-3]
- Ruthenium(II)-arene complexes of general formulae [(eta(6)-p-cymene)Ru(L1-3)Cl-2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), Correspondingly, [(eta(6)-p-cymene)Ru(HL4,5)Cl...
- Antioxidant and antiviral activities of silybin fatty acid conjugates
[作者:Gazak, R; Purchartova, K; Marhol, P; Zivna, L; Sedmera, P; Valentova, K; Kato, N; Matsumura, H; Kaihatsu, K; Kren, V,期刊:European Journal of Medicinal Chemistry, 页码:1059-1067 , 文章类型: Article,,卷期:2010年45-3]
- Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were teste...
- Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents
[作者:Karali, N; Guzel, O; Ozsoy, N; Ozbey, S; Salman, A,期刊:European Journal of Medicinal Chemistry, 页码:1068-1077 , 文章类型: Article,,卷期:2010年45-3]
- 3H-Spiro[1,3-benzothiazole-2,3'-indol]-2'(1',H)-ones 3a-c and 4a-e were synthesized from treating the 5-substituted 1H-indole-2,3-diones with 2-aminothiophenol in ethanol. The structures were confirmed by elemental analy...
- Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid
[作者:Singh, RK; Rai, D; Yadav, D; Bhargava, A; Balzarini, J; De Clercq, E,期刊:European Journal of Medicinal Chemistry, 页码:1078-1086 , 文章类型: Article,,卷期:2010年45-3]
- Curcumin bioconjugates, viz. di-O-tryptophanylphenylalanine curcumin (2), di-O-decanoyl curcumin (3), di-O-pamitoyl curcumin (4), di-O-bis-(gamma,gamma)folyl curcumin (6), C-4-ethyl-O-gamma-folyl curcumin (8) and 4-O-eth...
- Synthesis, antibacterial and antifungal activities of 6,5 fused steroidal oxazoles in cholestane series
[作者:Shamsuzzaman; Khan, MS; Alam, M; Tabassum, Z; Ahmad, A; Khan, AU,期刊:European Journal of Medicinal Chemistry, 页码:1094-1097 , 文章类型: Article,,卷期:2010年45-3]
- Herein, we report a convenient one-pot synthesis of 2'-amino-5 alpha-cholest-6-eno [6,5-d] oxazole derivatives (4-6). The synthesis involves the reaction of cholestan-6-ones (1-3) with urea and iodine. The structural ass...
- Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity
[作者:Koufaki, M; Theodorou, E; Alexi, X; Nikoloudaki, F; Alexis, MN,期刊:European Journal of Medicinal Chemistry, 页码:1107-1112 , 文章类型: Article,,卷期:2010年45-3]
- beta-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity...
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