- Support vector machines: Development of QSAR models for predicting anti-HIV-1 activity of TIBO derivatives
[作者:Darnag, R; Mazouz, ELM; Schmitzer, A; Villemin, D; Jarid, A; Cherqaoui, D,期刊:European Journal of Medicinal Chemistry, 页码:1590-1597 , 文章类型: Article,,卷期:2010年45-4]
- The tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepinone (TIBO) derivatives, as non-nucleoside reverse transcriptase inhibitors, acquire a significant place in the treatment of the infections by the HIV. In the present paper...
- Synthesis, characterization antibacterial and antiproliferative activity of novel Cu(II) and Pd(II) complexes with 2-hydroxy-8-R-tricyclo[7.3.1.0.(2,7)] tridecane-13-one thiosemicarbazone
[作者:Rosu, T; Pahontu, E; Pasculescu, S; Georgescu, R; Stanica, N; Curaj, A; Popescu, A; Leabu, M,期刊:European Journal of Medicinal Chemistry, 页码:1627-1634 , 文章类型: Article,,卷期:2010年45-4]
- Synthesis and biological activity investigation of complex compounds of Cu(II) are challenging issues because of the metal is not a xenobiotic one and the activity of ligands could be modulated by complexation. Complex c...
- Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives
[作者:Khobragade, CN; Bodade, RG; Konda, SG; Dawane, BS; Manwar, AV,期刊:European Journal of Medicinal Chemistry, 页码:1635-1638 , 文章类型: Article,,卷期:2010年45-4]
- Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives have been prepared by cyclocondensation of ethyl 2-cyano-3,3-bis(methylthio)prop-2-enoate with 2-amino-4-(substituted phenyl)thiazole to give 3-cyano-2-methylthio...
- QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations
[作者:Toropov, AA; Toropova, AP; Raska, I; Benfenati, E,期刊:European Journal of Medicinal Chemistry, 页码:1639-1647 , 文章类型: Article,,卷期:2010年45-4]
- Three different splits into the subtraining set (n = 22), the set of calibration (n = 21), and the test set (n = 12) of 55 antineoplastic agents have been examined. By the correlation balance of SMILES-based optimal desc...
- Synthesis and biological evaluation of water-soluble organogermanium
[作者:Choi, S; Oh, C; Han, J; Park, J; Choi, JH; Min, NY; Lee, KH; Park, AJ; Kim, YJ; Jang, SJ; Lee, DH; Ham, SW,期刊:European Journal of Medicinal Chemistry, 页码:1654-1656 , 文章类型: Article,,卷期:2010年45-4]
- Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with ...
- Evaluation of aldose reductase inhibition and docking studies of 6 '-nitro and 6 ',6 ''-dinitrorosmarinic acids
[作者:Koukoulitsa, C; Bailly, F; Pegklidou, K; Demopoulos, VJ; Cotelle, P,期刊:European Journal of Medicinal Chemistry, 页码:1663-1666 , 文章类型: Article,,卷期:2010年45-4]
- Aldose reductase (ALR2) of the polyol metabolic pathway is a target enzyme for the treatment of diabetic complications. A variety of synthetic and natural compounds have been observed to inhibit aldose reductase. Among t...
- Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones
[作者:Tomasic, T; Zidar, N; Mueller-Premru, M; Kikelj, D; Masic, LP,期刊:European Journal of Medicinal Chemistry, 页码:1667-1672 , 文章类型: Article,,卷期:2010年45-4]
- 5-Benzylidenethiazolidin-4-ones and 5-benzylidenepyrimidine-4,6-diones (compounds 1-9), carrying 2,3,4-trifluoro or 3,4,5-trimethoxy groups on the benzylidene moiety, and rhodanine derivatives 10 and 11 were synthesized ...
- First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin
[作者:Zhang, ZW; Zhang, JQ; Hui, L; Chen, SW; Tian, X,期刊:European Journal of Medicinal Chemistry, 页码:1673-1677 , 文章类型: Article,,卷期:2010年45-4]
- Deoxypodophyllotoxin inhibits tubulin polymerization and induces cell cycle arrest at G2/M, followed by apoptosis. In order to find compounds with superior bioactivity and less toxicity, a series of spin-labeled derivati...
- Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide
[作者:Alla, MSMA; Hegab, MI; Taleb, NAA; Hasabelnaby, SM; Goudah, A,期刊:European Journal of Medicinal Chemistry, 页码:1267-1277 , 文章类型: Article,,卷期:2010年45-4]
- Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR. H-1 NMR, MS and elemental analysis. Most of the new...
- Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity
[作者:Czopek, A; Byrtus, H; Kolaczkowski, M; Pawlowski, M; Dybala, M; Nowak, G; Tatarczynska, E; Wesolowska, A; Chojnacka-Wojcik, E,期刊:European Journal of Medicinal Chemistry, 页码:1295-1303 , 文章类型: Article,,卷期:2010年45-4]
- The synthesis of 5-(cyclo)alky1-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives with an arylpiperazinylpropyl moiety (12-23) and their in vitro and in vivo pharmacological properties and molecular characteristic...
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