- Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas
[作者:Franchini, MC; Bonini, BF; Camaggi, CM; Gentili, D; Pession, A; Rani, M; Strocchi, E,期刊:European Journal of Medicinal Chemistry, 页码:2024-2033 , 文章类型: Article,,卷期:2010年45-5]
- A series of novel 3,4-disubstituted pyrazoles were synthesized. The cytotoxicity against U87MG glioma cell line have been investigated in vitro and three of these compounds showed promising inhibitory activity on cell gr...
- Stilbene analogs as inducers of apolipoprotein-I transcription
[作者:Hansen, HC; Chiacchia, FS; Patel, R; Wong, NCW; Khlebnikov, V; Jankowska, R; Patel, K; Reddy, MM,期刊:European Journal of Medicinal Chemistry, 页码:2018-2023 , 文章类型: Article,,卷期:2010年45-5]
- Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more poten...
- Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus
[作者:Chezal, JM; Paeshuyse, J; Gaumet, V; Canitrot, D; Maisonial, A; Lartigue, C; Gueiffier, A; Moreau, E; Teulade, JC; Chavignon, O; Neyts, J,期刊:European Journal of Medicinal Chemistry, 页码:2044-2047 , 文章类型: Article,,卷期:2010年45-5]
- A series of imidazo[1,2-a]pyrrolo[2,3-c]pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, ...
- New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation
[作者:Angelusiu, MV; Barbuceanu, SF; Draghici, C; Almajan, GL,期刊:European Journal of Medicinal Chemistry, 页码:2055-2062 , 文章类型: Article,,卷期:2010年45-5]
- A new aroyl-hydrazone, N-(2-pyridinecarbaldehyde)-N'-[4-(4-chloro-phenylsulfonyl) benzoyl]-hydrazone (L) and its Cu(II). Co(II) and Ni(II) complexes have been prepared. The structure of these compounds has been investiga...
- Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents
[作者:Kumar, GVS; Rajendraprasad, Y; Mallikarjuna, BP; Chandrashekar, SM; Kistayya, C,期刊:European Journal of Medicinal Chemistry, 页码:2063-2074 , 文章类型: Article,,卷期:2010年45-5]
- In the present study a series of 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazole derivatives have been synthesized and characterized by IR, H-1 NMR, C-13 NMR and mass spectral analysis. Sy...
- Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates
[作者:Onajole, OK; Govender, P; van Heiden, PD; Kruger, HG; Maguire, GEM; Wiid, I; Govender, T,期刊:European Journal of Medicinal Chemistry, 页码:2075-2079 , 文章类型: Article,,卷期:2010年45-5]
- As part of an ongoing project to develop highly potent anti-tuberculosis therapeutics, six SQ109 derivatives were synthesized and screened in vitro for their anti-tuberculosis activity against the ATCC strain H37Rv and t...
- Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives
[作者:Ozdemir, A; Turan-Zitouni, G; Kaplancikli, ZA; Iscan, G; Khan, S; Demirci, F,期刊:European Journal of Medicinal Chemistry, 页码:2080-2084 , 文章类型: Article,,卷期:2010年45-5]
- Even though there are new classes of compounds now frequently used in treatment of fungal infections, the density of deeply invasive candidiasis has increased at least 10-fold during the past decade. Furthermore, many in...
- Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase
[作者:Niu, Y; Wang, YH; Zou, XM; Yang, XM; Ma, C; Lu, Y; Zhou, B; Yuan, Y; Du, GH; Xu, P,期刊:European Journal of Medicinal Chemistry, 页码:2089-2094 , 文章类型: Article,,卷期:2010年45-5]
- Based on the structure of OM99-2 and the X-ray crystal structure of its complex with beta-secretase, a series of compounds containing the Leu*Ala hydroxyethylene isostere as a scissile bond substitution were designed. 31...
- Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays
[作者:Kiselyov, AS; Semenova, MN; Chernyshova, NB; Leitao, A; Samet, AV; Kislyi, KA; Raihstat, MM; Oprea, T; Lemcke, H; Lantow, M; Weiss, DG; Ikizalp, NN; Kuznetsov, SA; Semenov, VV,期刊:European Journal of Medicinal Chemistry, 页码:1683-1697 , 文章类型: Article,,卷期:2010年45-5]
- A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic sea u...
- 3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity
[作者:Rocha, FV; Barra, CV; Netto, AVG; Mauro, AE; Carlos, IZ; Frem, RCG; Ananias, SR; Quilles, MB; Stevanato, A; da Rocha, MC,期刊:European Journal of Medicinal Chemistry, 页码:1698-1702 , 文章类型: Article,,卷期:2010年45-5]
- Complexes of the type [PdX2(tdmPz)] {X = Cl-(1) Br-(2); l(-)(3); SCN-(4); tdmPz = 1-thiocarbamoy1-3,5-dimethylpyrazole} have been synthesized and characterized. Compound 1 was formed from the reaction between [PdCl2(CH3C...
- Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge
[作者:Thaqi, A; Scott, JL; Gilbert, J; Sakoff, JA; McCluskey, A,期刊:European Journal of Medicinal Chemistry, 页码:1717-1723 , 文章类型: Article,,卷期:2010年45-5]
- Cantharidin (1) and norcantharidin (2) are potent protein phosphatase 1 and 2A inhibitors that also display high levels of anticancer activity against a broad range of tumor cells lines. Surprisingly, Delta-5,6-ethyl nor...
- Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters
[作者:Moraski, GC; Chang, M; Villegas-Estrada, A; Franzblau, SG; Mollmann, U; Miller, MJ,期刊:European Journal of Medicinal Chemistry, 页码:1703-1716 , 文章类型: Article,,卷期:2010年45-5]
- During the syntheses and studies of natural iron chelators (mycobactins), we serendipitously discovered that a simple, small molecule, oxazoline-containing intermediate 3 displayed surprising anti-tuberculosis activity (...
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