- Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and pi-acceptors
[作者:Siddiqui, FA; Arayne, MS; Sultana, N; Qureshi, F; Mirza, AZ; Zuberi, MH; Bahadur, SS; Afridi, NS; Shamshad, H; Rehman, N,期刊:European Journal of Medicinal Chemistry, 页码:2761-2767 , 文章类型: Article,,卷期:2010年45-7]
- Simple, rapid and sensitive spectrophotometric procedures are developed for the analysis of gabapentin in pure form as well as in their pharmaceutical formulations. The methods are based on the reaction of gabapentin as ...
- Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles
[作者:Kaur, H; Kumar, S; Vishwakarma, P; Sharma, M; Saxena, KK; Kumar, A,期刊:European Journal of Medicinal Chemistry, 页码:2777-2783 , 文章类型: Article,,卷期:2010年45-7]
- A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results c...
- Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes
[作者:Dumitrescu, L; Doan, TMH; Nguyen, VH; Crousse, B; Bonnet-Delpon, D,期刊:European Journal of Medicinal Chemistry, 页码:3213-3218 , 文章类型: Article,,卷期:2010年45-7]
- Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluorome...
- Synthesis and antitumor activity of novel 2 ',3 '-diethanethio-2 ',3 ',5 '-trideoxy-5 '-triazolonucleoside analogues
[作者:Yu, JL; Wu, QP; Zhang, QS; Xi, XD; Liu, NN; Li, YZ; Liu, YH; Yin, HQ,期刊:European Journal of Medicinal Chemistry, 页码:3219-3222 , 文章类型: Article,,卷期:2010年45-7]
- A series of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triaz...
- Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents
[作者:Zheng, QZ; Cheng, K; Zhang, XM; Liu, K; Jiao, QC; Zhu, HL,期刊:European Journal of Medicinal Chemistry, 页码:3207-3212 , 文章类型: Article,,卷期:2010年45-7]
- A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showe...
- Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents
[作者:Bandgar, BR; Patil, SA; Korbad, BL; Biradar, SC; Nile, SN; Khobragade, CN,期刊:European Journal of Medicinal Chemistry, 页码:3223-3227 , 文章类型: Article,,卷期:2010年45-7]
- This is the first report on aurones as a new class of drugs with anti-inflammatory and antimicrobial agents. A series of 2,2-bisaminomethylated aurone analogues (4a-j) were synthesized by Mannich reaction from 1,3,5-trim...
- Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain
[作者:Ettari, R; Zappala, M; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Evers, A; Grasso, S,期刊:European Journal of Medicinal Chemistry, 页码:3228-3233 , 文章类型: Article,,卷期:2010年45-7]
- This paper describes the synthesis of novel peptidomimetics bearing a protected aspartyl aldeyde warhead leading to the thioacylals 2a,b and the acylals 3a,b. Compounds 2a and 3a proved to possess an increased antiplasmo...
- Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies
[作者:Gao, EJ; Wang, KH; Zhu, MC; Liu, L,期刊:European Journal of Medicinal Chemistry, 页码:2784-2790 , 文章类型: Article,,卷期:2010年45-7]
- A novel tetranuclear palladium(II) complex [Pd-4(phen)(4) (mu-pydc)(4)]center dot 10H(2)O (phen = 1,10-phenanthroline, pydc = pyridine-3,4-dicarboxylate) has been synthesized and characterized. In the tetranuclear comple...
- QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors
[作者:Ravichandran, V; Shalini, S; Sundram, K; Sokkalingam, AD,期刊:European Journal of Medicinal Chemistry, 页码:2791-2797 , 文章类型: Article,,卷期:2010年45-7]
- A linear quantitative structure activity relationship (QSAR) model is presented for modeling and predicting the inhibition of HIV-1 integrase. The model was produced by using the stepwise multiple linear regression techn...
- Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents
[作者:Zhang, J; Zhang, YM; Shan, YY; Li, N; Ma, W; He, LC,期刊:European Journal of Medicinal Chemistry, 页码:2798-2805 , 文章类型: Article,,卷期:2010年45-7]
- Antiangiogenic therapy might represent a new promising anticancer therapeutic strategy. Taspine can significantly inhibit cell proliferation of human umbilical vein endothelial cells (HUVECs) induced by vascular endothel...
- Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
[作者:Kumar, D; Judge, V; Narang, R; Sangwan, S; De Clercq, E; Balzarini, J; Narasimhan, B,期刊:European Journal of Medicinal Chemistry, 页码:2806-2816 , 文章类型: Article,,卷期:2010年45-7]
- A series of benzylidene hydrazides (1-20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro sub...
- Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1 '-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)
[作者:Wouters, J; Elasaad, K; Norberg, B; Graulich, A; Liegeois, JF,期刊:European Journal of Medicinal Chemistry, 页码:3240-3244 , 文章类型: Article,,卷期:2010年45-7]
- Crystal structure of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute ...
- Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier
[作者:Fan, X; Zhang, HS; Chen, L; Long, YQ,期刊:European Journal of Medicinal Chemistry, 页码:2827-2840 , 文章类型: Article,,卷期:2010年45-7]
- By employing pharmacophore-based design and the privileged fragments reassembly, a series of piperidine-/tropane-/piperazine-bridged CCR5 antagonists were designed and synthesized via an efficient convergent synthesis st...
- Synthesis of novel 6,6a,7,8-tetrahydro-5H-naphtho[1,2-e]pyrimido[4,5-b][1,4]diazepines under microwave irradiation as potential anti-tumor agents
[作者:Insuasty, B; Garcia, A; Quiroga, J; Abonia, R; Nogueras, M; Cobo, J,期刊:European Journal of Medicinal Chemistry, 页码:2841-2846 , 文章类型: Article,,卷期:2010年45-7]
- A new series of 6,6a,7,8-tetrahydro-5H-naphtho[1,2-e]pyrimido[4,5-b][1,4]diazepines 4a-f and 5a-f were efficiently synthesized in good yields from the reaction of E-2-arylidene-1-tetralones 1 and the respective tri- or t...
- Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement
[作者:Rodrigues, C; Batista, AA; Ellena, J; Castellano, EE; Benitez, D; Cerecetto, H; Gonzalez, M; Teixeira, LR; Beraldo, H,期刊:European Journal of Medicinal Chemistry, 页码:2847-2853 , 文章类型: Article,,卷期:2010年45-7]
- Complexes [RuCl(H4NO(2)Fo4M)(bipy)(dppb)]PF6 (1), [RuCl(H4NO(2)Fo4M)(Mebipy)(dppb)]PF6 (2), [RuCl(H4NO(2)Fo4M)(phen)(dppb)]PF6 (3), [RuCl(H4NO(2)Ac4M)(bipy)(dppb)]PF6 (4), [RuCl(H4NO(2)Ac4M)(Mebipy)(dppb)]PF6 (5) and [Ru...
|