- Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives
[作者:Iqbal, PF; Parveen, H; Bhat, AR; Hayat, F; Azam, A,期刊:European Journal of Medicinal Chemistry, 页码:4747-4751 , 文章类型: Article,,卷期:2009年44-11]
- Cyclization of benzene-1,4-dicarbaldehyde dioxime 1 with different aromatic aldehydes in inert atmosphere yielded the corresponding new bisdioxazoles 2-11. The structure of 2-11 was elucidated by spectral data. In vitro ...
- Synthesis, characterization and evaluation of antibacterial activity of some thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties
[作者:Barbuceanu, SF; Almajan, GL; Saramet, L; Draghici, C; Tarcomnicu, AI; Bancescu, G,期刊:European Journal of Medicinal Chemistry, 页码:4752-4757 , 文章类型: Article,,卷期:2009年44-11]
- A series of thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties were synthesized starting from 5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thioles 3a-c, X=H, Cl, Br. Thus, alkylation of 1,2,4-t...
- Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine
[作者:Peixoto, P; Zeghida, W; Carrez, D; Wu, TD; Wattez, N; Croisy, A; Demeunynck, M; Guerquin-Kern, JL; Lansiaux, A,期刊:European Journal of Medicinal Chemistry, 页码:4758-4763 , 文章类型: Article,,卷期:2009年44-11]
- Aminoacridine derivatives display interesting chemical and biological properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labelled analogue allows the study of cell ...
- Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies
[作者:Boiani, M; Boiani, L; Merlino, A; Hernandez, P; Chidichimo, A; Cazzulo, JJ; Cerecetto, H; Gonzalez, M,期刊:European Journal of Medicinal Chemistry, 页码:4426-4433 , 文章类型: Article,,卷期:2009年44-11]
- Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strai...
- Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone
[作者:Bansal, R; Kumar, D; Carron, R; de la Calle, C,期刊:European Journal of Medicinal Chemistry, 页码:4441-4447 , 文章类型: Article,,卷期:2009年44-11]
- Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone are reported. An effect of substitution at 2-position of pyridazinone ring on vasodilatory pote...
- Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine
[作者:Khalil, AM; Berghot, MA; Gouda, MA,期刊:European Journal of Medicinal Chemistry, 页码:4448-4454 , 文章类型: Article,,卷期:2009年44-11]
- 3-(1,4-Dioxo-3,4,4e,5,10,10a-hexahydro-1H-5,10-benzeno-benzo[g]phthalazin-2-yl)-3-oxo-propiononitrile (1) was utilized as key intermediate for the synthesis of some new iminocoumarin 2, chromenone 3, aminothiazole 4, tri...
- Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: A convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N-4-benzoyl cytosine and N-6-benzoyl adenine
[作者:Manta, S; Tzioumaki, N; Tsoukala, E; Panagiotopoulou, A; Pelecanou, M; Balzarini, J; Komiotis, D,期刊:European Journal of Medicinal Chemistry, 页码:4764-4771 , 文章类型: Article,,卷期:2009年44-11]
- The beta-protected nucleosides of uracil (2a), 5-fluorouracil (2b), thymine (2c), N-4-benzoyl cytosine (2d) and N-6-benzoyl adenine (2e) were synthesized by condensation of the peracetylated 3-deoxy-3-fluoro-D-glucopyram...
- Synthesis, cytotoxicity and DNA-binding levels of new type binuclear platinum(II) complexes
[作者:Zhang, JC; Li, YP; Sun, J; Li, WX; Gong, YQ; Zheng, XM; Cui, JR; Wang, RQ; Wu, J,期刊:European Journal of Medicinal Chemistry, 页码:4772-4777 , 文章类型: Article,,卷期:2009年44-11]
- Six new type binuclear platinum(II) complexes (a-f) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, UV, H-1 NMR and mass spectra techniques. The cytotoxicity of the comp...
- Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data
[作者:Sui, XF; Sun, J; Li, HY; Wang, YJ; Liu, JF; Liu, XH; Zhang, WP; Chen, LJ; He, ZG,期刊:European Journal of Medicinal Chemistry, 页码:4455-4460 , 文章类型: Article,,卷期:2009年44-11]
- We developed an improved Lombardeo's method (J. Med. Chem., 2004) for prediction of VDss in human. With Elog D substituted by log k(IAM), together with f(i(7.4)) (the fraction of compound ionized at pH 7.4) and log f(u) ...
- Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors
[作者:Jiao, J; Fang, H; Wang, XJ; Guan, P; Yuan, YM; Xu, WF,期刊:European Journal of Medicinal Chemistry, 页码:4470-4476 , 文章类型: Article,,卷期:2009年44-11]
- A novel series of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives comprising N-hydroxybenzamide group as zinc-chelating moiety were designed, synthesized and evaluated for their ability to inhibit histone d...
- Synthesis, crystal structure, DNA interaction and antioxidant activities of two novel water-soluble Cu(2+) complexes derivated from 2-oxo-quinoline-3-carbaldehyde Schiff-bases
[作者:Liu, ZC; Wang, BD; Yang, ZY; Li, Y; Qin, DD; Li, TR,期刊:European Journal of Medicinal Chemistry, 页码:4477-4484 , 文章类型: Article,,卷期:2009年44-11]
- Two novel 2-oxo-quinoline-3-carbaldehyde (4'-hydroxybenzoyl) hydrazone, thiosemicarbazone ligands and its corresponding Cu(2+) complexes were synthesized, and the two complexes' structures were determined by X-ray single...
- Synthesis and antimalarial activity of new atovaquone derivatives
[作者:El Hage, S; Ane, M; Stigliani, JL; Marjorie, M; Vial, H; Baziard-Mouysset, G; Payard, M,期刊:European Journal of Medicinal Chemistry, 页码:4778-4782 , 文章类型: Article,,卷期:2009年44-11]
- In this paper we describe the design and synthesis of 18 derivatives of the antimicrobial atovaquone which were substituted at the 3-hydroxy group by ester and ether functions. The compounds were evaluated in vitro for t...
- Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappa B and AP-1 mediated transcription activation and as potential anti-inflammatory agents (vol 44, pg 2184, 2009)
[作者:Giri, RS; Thaker, HM; Giordano, T; Williams, J; Rogers, D; Sudersanam, V; Vasu, KK,期刊:European Journal of Medicinal Chemistry, 页码:4783-4783 , 文章类型: Correction,,卷期:2009年44-11]
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- Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors (vol 44, pg 1830, 2009)
[作者:Dundar, Y; Unlu, S; Banoglu, E; Entrena, A; Costantino, G; Nunez, MT; Ledo, F; Sahin, MF; Noyanalpan, N,期刊:European Journal of Medicinal Chemistry, 页码:4785-4785 , 文章类型: Correction,,卷期:2009年44-11]
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