- Effects of the Cognition-Enhancing Agent ABT-239 on Fetal Ethanol-Induced Deficits in Dentate Gyrus Synaptic Plasticity
[作者:Varaschin, RK; Akers, KG; Rosenberg, MJ; Hamilton, DA; Savage, DD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:191-198 , 文章类型: Article,,卷期:2010年334-1]
- Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically effective pharmacotherapeutic interventions for these deficits. In this study, we examined wh...
- Terutroban, a Thromboxane/Prostaglandin Endoperoxide Receptor Antagonist, Increases Survival in Stroke-Prone Rats by Preventing Systemic Inflammation and Endothelial Dysfunction: Comparison with Aspirin and Rosuvastatin
[作者:Gelosa, P; Ballerio, R; Banfi, C; Nobili, E; Gianella, A; Pignieri, A; Brioschi, M; Guerrini, U; Castiglioni, L; Blanc-Guillemaud, V; Lerond, L; Tremoli, E; Sironi, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:199-205 , 文章类型: Article,,卷期:2010年334-1]
- This study investigated the efficacy of terutroban, a specific thromboxane/prostaglandin endoperoxide receptor antagonist, on stroke incidence in spontaneously hypertensive stroke-prone rats (SHRSP). The effects of terut...
- Metformin, an Antidiabetic Agent, Suppresses the Production of Tumor Necrosis Factor and Tissue Factor by Inhibiting Early Growth Response Factor-1 Expression in Human Monocytes in Vitro
[作者:Arai, M; Uchiba, M; Komura, H; Mizuochi, Y; Harada, N; Okajima, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:206-213 , 文章类型: Article,,卷期:2010年334-1]
- Metformin, an antidiabetic agent, has been shown to reduce atherothrombotic disease in diabetic patients independent of antihyperglycemic effect. Recent studies have demonstrated that metformin attenuates the proinflamma...
- Endothelium-Derived Nitric Oxide Inhibits the Relaxation of the Porcine Coronary Artery to Natriuretic Peptides by Desensitizing Big Conductance Calcium-Activated Potassium Channels of Vascular Smooth Muscle
[作者:Liang, CF; Au, ALS; Leung, SWS; Ng, KFJ; Feletou, M; Kwan, YW; Man, RYK; Vanhoutte, PM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:223-231 , 文章类型: Article,,卷期:2010年334-1]
- The present experiments investigated whether endothelium-derived mediators modulate the effect of natriuretic peptides in porcine coronary arteries. Rings with and without endothelium were suspended in organ chambers for...
- Neuropeptide FF Receptors Have Opposing Modulatory Effects on Nociception
[作者:Lameh, J; Bertozzi, F; Kelly, N; Jacobi, PM; Nguyen, D; Bajpai, A; Gaubert, G; Olsson, R; Gardell, LR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:244-254 , 文章类型: Article,,卷期:2010年334-1]
- The role of neuropeptide FF (NPFF) and its analogs in pain modulation is ambiguous. Although NPFF was first characterized as an antiopioid peptide, both antinociceptive and pronociceptive effects have been reported, depe...
- Pharmacodynamic and Pharmacokinetic Characterization of the Aldosterone Synthase Inhibitor FAD286 in Two Rodent Models of Hyperaldosteronism: Comparison with the 11 beta-Hydroxylase Inhibitor Metyrapone
[作者:Rigel, DF; Fu, FM; Beil, M; Hu, CW; Liang, GQ; Jeng, AY,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:232-243 , 文章类型: Article,,卷期:2010年334-1]
- Aldosterone synthase (CYP11B2) inhibitors (ASIs) represent an attractive therapeutic approach for mitigating the untoward effects of aldosterone. We characterized the pharmacokinetic/pharmacodynamic relationships of a pr...
- NAD(P) H: quinone Oxidoreductase 1-Compromised Human Bone Marrow Endothelial Cells Exhibit Decreased Adhesion Molecule Expression and CD34(+) Hematopoietic Cell Adhesion
[作者:Zhou, HF; Dehn, D; Kepa, JK; Siegel, D; Scott, DE; Tan, W; Ross, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:260-268 , 文章类型: Article,,卷期:2010年334-1]
- NAD(P) H: quinone oxidoreductase 1 (NQO1) deficiency resulting from a homozygous NQO1*2 polymorphism has been associated with an increased risk of benzene-induced myeloid toxicity and a variety of de novo and therapy-ind...
- Pharmacodynamics and Pharmacokinetics of the gamma-Secretase Inhibitor PF-3084014
[作者:Lanz, TA; Wood, KM; Richter, KEG; Nolan, CE; Becker, SL; Pozdnyakov, N; Martin, BA; Du, P; Oborski, CE; Wood, DE; Brown, TM; Finley, JE; Sokolowski, SA; Hicks, CD; Coffman, KJ; Geoghegan, KF; Brodney, MA; Liston, D; Tate, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:269-277 , 文章类型: Article,,卷期:2010年334-1]
- PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen- 3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a novel gamma-secretase inhibitor that reduces amyloid-beta (A b...
- Ascorbylperoxide Contaminating Parenteral Nutrition Perturbs the Lipid Metabolism in Newborn Guinea Pig
[作者:Maghdessian, R; Cote, F; Rouleau, T; Ouadda, AB; Levy, E; Lavoie, JC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:278-284 , 文章类型: Article,,卷期:2010年334-1]
- The light exposure of parenteral nutritive solutions generates peroxides such as H2O2 and ascorbylperoxide[2,3-diketo-4-hydoxyperoxyl-5,6-dihydroxyhexanoic acid]. This absence of photoprotection is associated with higher...
- The Combi-Targeting Concept: Selective Targeting of the Epidermal Growth Factor Receptor- and Her2-Expressing Cancer Cells by the Complex Combi-Molecule RB24
[作者:Banerjee, R; Huang, Y; McNamee, JP; Todorova, M; Jean-Claude, BJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:9-20 , 文章类型: Article,,卷期:2010年334-1]
- Within the context of a new tumor-targeting strategy termed "combi-targeting," we designed RB24 to inhibit epidermal growth factor receptor (EGFR) or Her2 phosphorylation and to further degrade upon hydrolysis to 4-(3'-b...
- Identification of beta-Escin as a Novel Inhibitor of Signal Transducer and Activator of Transcription 3/Janus-Activated Kinase 2 Signaling Pathway that Suppresses Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cells
[作者:Tan, SML; Li, F; Rajendran, P; Kumar, AP; Hui, KM; Sethi, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:285-293 , 文章类型: Article,,卷期:2010年334-1]
- The activation of signal transducer and activator of transcription 3 (STAT3) has been linked with the proliferation, survival, invasion, and angiogenesis of a variety of human cancer cells, including hepatocellular carci...
- Pharmacology of PF-4191834, a Novel, Selective Non-Redox 5-Lipoxygenase Inhibitor Effective in Inflammation and Pain
[作者:Masferrer, JL; Zweifel, BS; Hardy, M; Anderson, GD; Dufield, D; Cortes-Burgos, L; Pufahl, RA; Graneto, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:294-301 , 文章类型: Article,,卷期:2010年334-1]
- 5-Lipoxygenase (LOX) is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators with potent pathophysiological functions in asthma and other inflammatory disease...
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