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  • The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1
    [作者:Duffin, R; Leitch, AE; Sheldrake, TA; Hallett, JM; Meyer, C; Fox, S; Alessandri, AL; Martin, MC; Brady, HJ; Teixeira, MM; Dransfield, I; Haslett, C; Rossi, AG,期刊:FEBS Letters, 页码:2540-2546 , 文章类型: Article,,卷期:2009年583-15]
  • Eosinophils are major players in inflammatory allergic diseases such as asthma, hay fever and eczema. Here we show that the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine efficiently and rapidly induces human eos...