- Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
[作者:Yamashita, M; Nonaka, T; Arai, T; Kametani, F; Buchman, VL; Ninkina, N; Bachurin, SO; Akiyama, H; Goedert, M; Hasegawa, M,期刊:FEBS Letters, 页码:2419-2424 , 文章类型: Article,,卷期:2009年583-14]
- Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are major neurodegenerative diseases with TDP-43 pathology. Here we investigated the effects of methylene b...
- N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins
[作者:Polyansky, AA; Vassilevski, AA; Volynsky, PE; Vorontsova, OV; Samsonova, OV; Egorova, NS; Krylov, NA; Feofanov, AV; Arseniev, AS; Grishin, EV; Efremov, RG,期刊:FEBS Letters, 页码:2425-2428 , 文章类型: Article,,卷期:2009年583-14]
- In silico structural analyses of sets of alpha-helical antimicrobial peptides (AMPs) are performed. Differences between hemolytic and non-hemolytic AMPs are revealed in organization of their N-terminal region. A paramete...
- Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation
[作者:Song, I; Kim, JH; Kim, K; Jin, HM; Youn, BU; Kim, N,期刊:FEBS Letters, 页码:2435-2440 , 文章类型: Article,,卷期:2009年583-14]
- NFATc1 is a master regulator of RANKL-induced osteoclast differentiation and herein we investigate the regulatory mechanism of NFATc1 in osteoclast activation. Inactivation of NFATc1 strongly attenuates RANKL-induced bon...
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