- Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer
[作者:Laurent-Puig, P; Cayre, A; Manceau, G; Buc, E; Bachet, JB; Lecomte, T; Rougier, P; Lievre, A; Landi, B; Boige, V; Ducreux, M; Ychou, M; Bibeau, F; Bouche, O; Reid, J; Stone, S; Penault-Llorca, F,期刊:Journal of clinical oncology, 页码:5924-5930 , 文章类型: Article,,卷期:2009年27-35]
- Purpose The occurrence of KRAS mutation is predictive of nonresponse and shorter survival in patients treated by anti-epidermal growth factor receptor (anti-EGFR) antibody for metastatic colorectal cancer (mCRC), leading...
- KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial
[作者:Richman, SD; Seymour, MT; Chambers, P; Elliott, F; Daly, CL; Meade, AM; Taylor, G; Barrett, JH; Quirke, P,期刊:Journal of clinical oncology, 页码:5931-5937 , 文章类型: Article,,卷期:2009年27-35]
- Purpose Activating mutation of the KRAS oncogene is an established predictive biomarker for resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies in advanced colorectal cancer (aCRC). We wanted to det...
- In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer
[作者:Pages, F; Kirilovsky, A; Mlecnik, B; Asslaber, M; Tosolini, M; Bindea, G; Lagorce, C; Wind, P; Marliot, F; Bruneval, P; Zatloukal, K; Trajanoski, Z; Berger, A; Fridman, WH; Galon, J,期刊:Journal of clinical oncology, 页码:5944-5951 , 文章类型: Article,,卷期:2009年27-35]
- Purpose Many patients who present with early-stage colorectal cancer (International Union Against Cancer TNM stages I and II) are nevertheless at high risk of relapse. We hypothesized that intratumoral immune reaction co...
- Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors
[作者:Quinn, GP; Vadaparampil, ST; Lee, JH; Jacobsen, PB; Bepler, G; Lancaster, J; Keefe, DL; Albrecht, TL,期刊:Journal of clinical oncology, 页码:5952-5957 , 文章类型: Article,,卷期:2009年27-35]
- Purpose Cancer survival rates are improving, and the focus is moving toward quality survival. Fertility is a key aspect of quality of life for cancer patients of childbearing age. Although cancer treatment may impair fer...
- Reporting of Time-to-Event End Points and Tracking of Failures in Randomized Trials of Radiotherapy With or Without Any Concomitant Anticancer Agent for Locally Advanced Head and Neck Cancer
[作者:Le Tourneau, C; Michiels, S; Gan, HK; Siu, LL,期刊:Journal of clinical oncology, 页码:5965-5971 , 文章类型: Article,,卷期:2009年27-35]
- Purpose For multiple reasons, including complexities in anatomy and management, locally advanced squamous cell carcinomas of the head and neck (SCCHNs) represent a challenging disease for the reporting of end points and ...
- Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects
[作者:Trevin, LR; Shimasaki, N; Yang, WJ; Panetta, JC; Cheng, C; Pei, DQ; Chan, D; Sparreboom, A; Giacomini, KM; Pui, CH; Evans, WE; Relling, MV,期刊:Journal of clinical oncology, 页码:5972-5978 , 文章类型: Article,,卷期:2009年27-35]
- Purpose Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acu...
- Trying to Be a Good Parent As Defined By Interviews With Parents Who Made Phase I, Terminal Care, and Resuscitation Decisions for Their Children
[作者:Hinds, PS; Oakes, LL; Hicks, J; Powell, B; Srivastava, DK; Spunt, SL; Harper, J; Baker, JN; West, NK; Furman, WL,期刊:Journal of clinical oncology, 页码:5979-5985 , 文章类型: Article,,卷期:2009年27-35]
- Purpose When a child's cancer progresses beyond current treatment capability, the parents are likely to participate in noncurative treatment decision making. One factor that helps parents to make these decisions and rema...
- Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia
[作者:Kadan-Lottick, NS; Brouwers, P; Breiger, D; Kaleita, T; Dziura, J; Northrup, V; Chen, L; Nicoletti, M; Bostrom, B; Stork, L; Neglia, JP,期刊:Journal of clinical oncology, 页码:5986-5992 , 文章类型: Article,,卷期:2009年27-35]
- Purpose For the majority of children with acute lymphoblastic leukemia (ALL), CNS prophylaxis consists of either intrathecal (IT) methotrexate or triple IT therapy (ie, methotrexate with both cytarabine and hydrocortison...
- Evaluating the Combined Effect of Comorbidity and Prostate-Specific Antigen Kinetics on the Risk of Death in Men After Prostate-Specific Antigen Recurrence
[作者:Wo, JY; Chen, MH; Nguyen, PL; Renshaw, AA; Loffredo, MJ; Kantoff, PW; D'Amico, AV,期刊:Journal of clinical oncology, 页码:6000-6005 , 文章类型: Article,,卷期:2009年27-35]
- Purpose We examined whether time-dependent continuous prostate-specific antigen (PSA) velocity at recurrence was associated with all cause mortality (ACM) adjusting for comorbidity levels among men treated with definitiv...
- Phase II Study of Cisplatin Plus Etoposide and Bevacizumab for Previously Untreated, Extensive-Stage Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Study E3501
[作者:Horn, L; Dahlberg, SE; Sandler, AB; Dowlati, A; Moore, DF; Murren, JR; Schiller, JH,期刊:Journal of clinical oncology, 页码:6006-6011 , 文章类型: Article,,卷期:2009年27-35]
- Purpose To investigate the efficacy and safety of bevacizumab plus cisplatin and etoposide in patients with extensive-stage disease, small-cell lung cancer (ED-SCLC). Patients and Methods In this phase II trial, 63 patie...
- Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease
[作者:Lin, TS; Ruppert, AS; Johnson, AJ; Fischer, B; Heerema, NA; Andritsos, LA; Blum, KA; Flynn, JM; Jones, JA; Hu, WH; Moran, ME; Mitchell, SM; Smith, LL; Wagner, AJ; Raymond, CA; Schaaf, LJ; Phelps, MA; Villalona-Calero, MA; Grever, MR; Byrd, JC,期刊:Journal of clinical oncology, 页码:6012-6018 , 文章类型: Article,,卷期:2009年27-35]
- Purpose Patients with chronic lymphocytic leukemia (CLL) with high-risk genomic features achieve poor outcomes with traditional therapies. A phase I study of a pharmacokinetically derived schedule of flavopiridol suggest...
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