- MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice
[作者：Roth, RJ; Le, AM; Zhang, L; Kahn, M; Samuel, VT; Shulman, GI; Bennett, AM,期刊：Journal of clinical investigation, 页码：3817-3829 , 文章类型： Article，,卷期：2009年119-12]
- Oxidative myofibers, also known as slow-twitch myofibers, help maintain the metabolic health of mammals, and it has been proposed that decreased numbers correlate with increased risk of obesity. The transcriptional coact...
- LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice
[作者：Touvier, T; Conte-Auriol, F; Briand, O; Cudejko, C; Paumelle, R; Caron, S; Bauge, E; Rouille, Y; Salles, JP; Staels, B; Bailleul, B,期刊：Journal of clinical investigation, 页码：3830-3838 , 文章类型： Article，,卷期：2009年119-12]
- Growth hormone (GH) is a major metabolic regulator that functions by stimulating lipolysis, preventing protein catabolism, and decreasing insulin-dependent glucose disposal. Modulation of hepatic sensitivity to GH and th...
- Inflammasomes: too big to miss
[作者：Stutz, A; Golenbock, DT; Latz, E,期刊：Journal of clinical investigation, 页码：3502-3511 , 文章类型： Review，,卷期：2009年119-12]
- Inflammation is the coordinated immune response to,harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue response...
- Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice
[作者：Huang, J; Zhang, Y; Bersenev, A; O'Brien, WT; Tong, W; Emerson, SG; Klein, PS,期刊：Journal of clinical investigation, 页码：3519-3529 , 文章类型： Article，,卷期：2009年119-12]
- Hematopoietic stem cell (HSC) homeostasis depends on the balance between self renewal and lineage commitment, but what regulates this decision is not well understood. Using loss-of-function approaches in mice, we found t...
- Essential role of the RNA-binding protein HuR in progenitor cell survival in mice
[作者：Ghosh, M; Aguila, HL; Michaud, J; Ai, YX; Wu, MT; Hemmes, A; Ristimaki, A; Guo, CY; Furneaux, H; Hla, T,期刊：Journal of clinical investigation, 页码：3530-3543 , 文章类型： Article，,卷期：2009年119-12]
- The RNA-binding protein HuR (also known as ELAV1) binds to the 3'-untranslated region of mRNAs and regulates transcript stability and translation. However, the in vivo functions of HuR are not well understood. Here, we r...
- Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response
[作者：Jacquelin, B; Mayau, V; Targat, B; Liovat, AS; Kunkel, D; Petitjean, G; Dillies, MA; Roques, P; Butor, C; Silvestri, G; Giavedoni, LD; Lebon, P; Barre-Sinoussi, F; Benecke, A; Muller-Trutwin, MC,期刊：Journal of clinical investigation, 页码：3544-3555 , 文章类型： Article，,卷期：2009年119-12]
- African green monkeys (AGMs) infected with the AGM type of SIV (SIVagm) do not develop chronic immune activation and AIDS, despite viral loads similar to those detected in humans infected with HIV-1 and rhesus macaques (...
- Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
[作者：Bosinger, SE; Li, QS; Gordon, SN; Klatt, NR; Duan, LJ; Xu, LL; Francella, N; Sidahmed, A; Smith, AJ; Cramer, EM; Zeng, M; Masopust, D; Carlis, JV; Ran, LS; Vanderford, TH; Paiardini, M; Isett, RB; Baldwin, DA; Else, JG; Staprans, SI; Silvestri, G; Haase, AT; Kelvin, DJ,期刊：Journal of clinical investigation, 页码：3556-3572 , 文章类型： Article，,卷期：2009年119-12]
- Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (R...
- Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
[作者：Eyerich, S; Eyerich, K; Pennino, D; Carbone, T; Nasorri, F; Pallotta, S; Cianfarani, F; Odorisio, T; Traidl-Hoffmann, C; Behrendt, H; Durham, SR; Schmidt-Weber, CB; Cavani, A,期刊：Journal of clinical investigation, 页码：3573-3585 , 文章类型： Article，,卷期：2009年119-12]
- Th subsets are defined according to their production of lineage-indicating cytokines and functions. In this study, we have identified a subset of human Th cells that infiltrates the epidermis in individuals with inflamma...
- Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction
[作者：Puig, I; Champeval, D; Barbara, PD; Jaubert, F; Lyonnet, S; Larue, L,期刊：Journal of clinical investigation, 页码：3586-3596 , 文章类型： Article，,卷期：2009年119-12]
- Intestinal ganglioneuromatosis is a benign proliferation of nerve ganglion cells, nerve fibers, and supporting cells of the enteric nervous system (ENS) that can result in abnormally large enteric neuronal cells (ENCs) i...
- Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice
[作者：Beetz, N; Harrison, MD; Brede, M; Zong, X; Urbanski, MJ; Sietmann, A; Kaufling, J; Barrot, M; Seeliger, MW; Vieira-Coelho, MA; Hamet, P; Gaudet, D; Seda, O; Tremblay, J; Kotchen, TA; Kaldunski, M; Nusing, R; Szabo, B; Jacob, HJ; Cowley, AW; Biel, M; Stoll, M; Lohse, MJ; Broeckel, U; Hein, L,期刊：Journal of clinical investigation, 页码：3597-3612 , 文章类型： Article，,卷期：2009年119-12]
- Hypertension and its complications represent leading causes of morbidity and mortality. Although the cause of hypertension is unknown in most patients, genetic factors are recognized as contributing significantly to an i...
- Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
[作者：Santos, AM; Jung, J; Aziz, N; Kissil, JL; Pure, E,期刊：Journal of clinical investigation, 页码：3613-3625 , 文章类型： Article，,卷期：2009年119-12]
- Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis, angiogenesis, and metastasis. However, the mechanisms by which they regulate these processes remain unknown. As the cell surface seri...
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