- Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice
[作者:Kovacic, JC; Gupta, R; Lee, AC; Ma, MC; Fang, F; Tolbert, CN; Walts, AD; Beltran, LE; San, H; Chen, GB; St Hilaire, C; Boehm, M,期刊:Journal of clinical investigation, 页码:303-314 , 文章类型: Article,,卷期:2010年120-1]
- Inflammation is a key component of arterial injury, with VSMC proliferation and neointimal formation serving as the final outcomes of this process. However, the acute events transpiring immediately after arterial injury ...
- IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
[作者:Li, L; Huang, LP; Vergis, AL; Ye, H; Bajwa, A; Narayan, V; Strieter, RM; Rosin, DL; Okusa, MD,期刊:Journal of clinical investigation, 页码:331-342 , 文章类型: Article,,卷期:2010年120-1]
- The IL-23/IL-17 and IL-12/IFN-gamma cytokine pathways have a role in chronic autoimmunity, which is considered mainly a dysfunction of adaptive immunity. The extent to which they contribute to innate immunity is, however...
- The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease
[作者:Na, IK; Lu, SX; Yim, NL; Goldberg, GL; Tsai, J; Rao, U; Smith, OM; King, CG; Suh, D; Hirschhorn-Cymerman, D; Palomba, L; Penack, O; Holland, AM; Jenq, RR; Ghosh, A; Tran, H; Merghoub, T; Liu, C; Sempowski, GD; Ventevogel, M; Beauchemin, N; van den Brink, MRM,期刊:Journal of clinical investigation, 页码:343-356 , 文章类型: Article,,卷期:2010年120-1]
- Thymic graft-versus-host disease (tGVHD) can contribute to profound T cell deficiency and repertoire restriction after allogeneic BM transplantation (allo-BMT). However, the cellular mechanisms of tGVHD and interactions ...
- FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
[作者:Rached, MT; Kode, A; Silva, BC; Jung, DY; Gray, S; Ong, H; Paik, JH; DePinho, RA; Kim, JK; Karsenty, G; Kousteni, S,期刊:Journal of clinical investigation, 页码:357-368 , 文章类型: Article,,卷期:2010年120-1]
- Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. it is unknown, however, how this osteoblast function is regulated transcriptionally. As FoxO1 is a fo...
- Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
[作者:Jarecki, BW; Piekarz, AD; Jackson, JO; Cummins, TR,期刊:Journal of clinical investigation, 页码:369-378 , 文章类型: Article,,卷期:2010年120-1]
- Inherited mutations in voltage-gated sodium channels (VGSCs; or Nav) cause many disorders of excitability, including epilepsy, chronic pain, myotonia, and cardiac arrhythmias. Understanding the functional consequences of...
- Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
[作者:Wilson, AA; Murphy, GJ; Hamakawa, H; Kwok, LW; Srinivasan, S; Hovav, AH; Mulligan, RC; Amar, S; Suki, B; Kotton, DN,期刊:Journal of clinical investigation, 页码:379-389 , 文章类型: Article,,卷期:2010年120-1]
- Directed gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human alpha 1 antitrypsin (hAAT) def...
- TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury (vol 115, pg 2393, 2005)
[作者:Obata, K; Katsura, H; Mizushima, T; Yamanaka, H; Kobayashi, K; Dai, Y; Fukuoka, T; Tokunaga, A; Tominaga, M; Noguchi, K,期刊:Journal of clinical investigation, 页码:394-394 , 文章类型: Correction,,卷期:2010年120-1]
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- Pabnitic acid mediates hypothalamic insulin resistance by altering PKC-q subcellular localization in rodents (vol 119, pg 2577, 2009)
[作者:Benoit, SC; Kemp, CJ; Elias, CF; Abplanalp, W; Herman, JP; Migrenne, S; Lefevre, AL; Cruciani-Guglielmacci, C; Magnan, C; Yu, F; Niswender, K; Irani, BG; Holland, WL; Clegg, DJ,期刊:Journal of clinical investigation, 页码:394-394 , 文章类型: Correction,,卷期:2010年120-1]
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- A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans (vol 119, pg 3666, 2009)
[作者:Li, H; Xie, H; Liu, W; Hu, R; Huang, B; Tan, YF; Xu, K; Sheng, ZF; Zhou, HD; Wu, XP; Luo, XH,期刊:Journal of clinical investigation, 页码:395-395 , 文章类型: Correction,,卷期:2010年120-1]
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- Let's keep this brief
[作者:Neill, US,期刊:Journal of clinical investigation, 页码:2-2 , 文章类型: Editorial Material,,卷期:2010年120-1]
- The regular articles and technical advances published in this issue are an average of 9,050 words, with 8.4 display items (figures and tables). Do we always need so many words to convey a message? We think not. With this...
- Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
[作者:Tedesco, FS; Dellavalle, A; Diaz-Manera, J; Messina, G; Cossu, G,期刊:Journal of clinical investigation, 页码:11-19 , 文章类型: Review,,卷期:2010年120-1]
- Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between t...
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