- Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
[作者：Olivera, A; Eisner, C; Kitamura, Y; Dillahunt, S; Allende, L; Tuymetova, G; Watford, W; Meylan, F; Diesner, SC; Li, LL; Schnermann, J; Proia, RL; Rivera, J,期刊：Journal of clinical investigation, 页码：1429-1440 , 文章类型： Article，,卷期：2010年120-5]
- Sphingosine kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (SIP), a ligand for a family of G protein-coupled receptors (S1PR1-S1PR5) with important functions in the vascular and i...
- Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPAR gamma in obese mice and humans
[作者：Lefebvre, B; Benomar, Y; Guedin, A; Langlois, A; Hennuyer, N; Dumont, J; Bouchaert, E; Dacquet, C; Penicaud, L; Casteilla, L; Pattou, F; Ktorza, A; Staels, B; Lefebvre, P,期刊：Journal of clinical investigation, 页码：1454-1468 , 文章类型： Article，,卷期：2010年120-5]
- Obese patients have chronic, low-grade inflammation that predisposes to type 2 diabetes and results, in part, from dysregulated visceral white adipose tissue (WAT) functions. The specific signaling pathways underlying WA...
- Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
[作者：Chavele, KM; Martinez-Pomares, L; Domin, J; Pemberton, S; Haslam, SM; Dell, A; Cook, HT; Pusey, CD; Gordon, S; Salama, AD,期刊：Journal of clinical investigation, 页码：1469-1478 , 文章类型： Article，,卷期：2010年120-5]
- Crescentic glomerulonephritis (CGN), which frequently results in acute and chronic kidney disease, is characterized by and dependent on glomerular infiltration by macrophages. The mannose receptor (MR) is a pattern recog...
- Altered regulatory T cell homeostasis in patients with CD4(+) lymphopenia following allogeneic hematopoietic stern cell transplantation
[作者：Matsuoka, K; Kim, HT; McDonough, S; Bascug, G; Warshauer, B; Koreth, J; Cutler, C; Ho, VT; Alyea, EP; Antin, JH; Soiffer, RJ; Ritz, J,期刊：Journal of clinical investigation, 页码：1479-1493 , 文章类型： Article，,卷期：2010年120-5]
- CD4(+)CD25(+)Foxp3(+) Tregs have an indispensable role in the maintenance of tolerance after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease (GVHD) have fewer circulating Tregs, but...
- Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice
[作者：Ahuja, P; Zhao, P; Angelis, E; Ruan, HM; Korge, P; Olson, A; Wang, YB; Jin, ES; Jeffrey, FM; Portman, M; MacLellan, WR,期刊：Journal of clinical investigation, 页码：1494-1505 , 文章类型： Article，,卷期：2010年120-5]
- In the adult heart, regulation of fatty acid oxidation and mitochondrial genes is controlled by the PPAR gamma coactivator-1 (PGC-1) family of transcriptional coactivators. However, in response to pathological stressors ...
- Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents
[作者：Shimizu, I; Minamino, T; Toko, H; Okada, S; Ikeda, H; Yasuda, N; Tateno, K; Moriya, J; Yokoyama, M; Nojima, A; Koh, GY; Akazawa, H; Shiojima, I; Kahn, CR; Abel, ED; Komuro, I,期刊：Journal of clinical investigation, 页码：1506-1514 , 文章类型： Article，,卷期：2010年120-5]
- Although many animal studies indicate insulin has cardioprotective effects, clinical studies suggest a link between insulin resistance (hyperinsulinemia) and heart failure (HF). Here we have demonstrated that excessive c...
- Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
[作者：Sood, AK; Armaiz-Pena, GN; Haider, J; Nick, AM; Stone, RL; Hu, W; Carroll, AR; Spannuth, WA; Deavers, MT; Allen, JK; Han, LY; Kamat, AA; Shahzad, MMK; McIntyre, BW; Diaz-Montero, CM; Jennings, NB; Lin, YG; Merritt, WM; DeGeest, K; Vivas-Mejia, PE; Lopez-Berestein, G; Schaller, MD; Cole, SW; Lutgendorf, SK,期刊：Journal of clinical investigation, 页码：1515-1523 , 文章类型： Article，,卷期：2010年120-5]
- Chronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine systems, but the effects of stress on cancer growth and progression are not fully understoo...
- FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth
[作者：Zhang, J; Zhao, DP; Park, HK; Wang, H; Dyer, RB; Liu, WG; Klee, GG; McNiven, MA; Tindall, DJ; Molina, JR; Fei, PW,期刊：Journal of clinical investigation, 页码：1524-1534 , 文章类型： Article，,卷期：2010年120-5]
- Fanconi anemia (FA) is a rare human genetic disease caused by mutations in any one of 13 known genes that encode proteins functioning in one common signaling pathway, the FA pathway, or in unknown genes. One characterist...
- HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype
[作者：Gilbert, PM; Mouw, JK; Unger, MA; Lakins, JN; Gbegnon, MK; Clemmer, VB; Benezra, M; Licht, JD; Boudreau, NJ; Tsai, KKC; Welm, AL; Feldman, MD; Weber, BL; Weaver, VM,期刊：Journal of clinical investigation, 页码：1535-1550 , 文章类型： Article，,卷期：2010年120-5]
- Breast cancer 1, early onset (BRCA1) expression is often reduced in sporadic breast tumors, even in the absence of BRCA1 genetic modifications, but the molecular basis for this is unknown. In this study, we identified ho...
- Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice
[作者：Kottke, T; Hall, G; Pulido, J; Diaz, RM; Thompson, J; Chong, H; Selby, P; Coffey, M; Pandha, H; Chester, J; Melcher, A; Harrington, K; Vile, R,期刊：Journal of clinical investigation, 页码：1551-1560 , 文章类型： Article，,卷期：2010年120-5]
- Clinical trials of oncolytic virotherapy have shown low toxicity and encouraging signs of efficacy. However, it remains critically important to develop methods for systemic viral delivery if such therapies are to be clin...
- Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice
[作者：Thomason, HA; Zhou, HQ; Kouwenhoven, EN; Dotto, GP; Restivo, G; Nguyen, BC; Little, HL; Dixon, MJ; van Bokhoven, H; Dixon, J,期刊：Journal of clinical investigation, 页码：1561-1569 , 文章类型： Article，,卷期：2010年120-5]
- Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births and results in considerable morbidity to affected individuals and their families. The etiology of cleft palate is complex, with...
- regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
[作者：Moretti, F; Marinari, B; Lo Lacono, N; Batt, E; Giunta, A; Spallone, G; Garaffo, G; Vernersson-Lindahl, E; Merlo, G; Mills, AA; Ballaro, C; Alema, S; Chimenti, S; Guerrini, L; Costanzo, A,期刊：Journal of clinical investigation, 页码：1570-1577 , 文章类型： Article，,卷期：2010年120-5]
- The human congenital syndromes ectrodactyly ectodermal dysplasia-cleft lip/palate syndrome, ankyloblepharon ectodermal dysplasia clefting, and split-hand/foot malformation are all characterized by ectodermal dysplasia, l...
- The diabetogenic mouse MHC class II molecule I-A(g7) is endowed with a switch that modulates TCR affinity
[作者：Yoshida, K; Corper, AL; Herro, R; Jabri, B; Wilson, IA; Teyton, L,期刊：Journal of clinical investigation, 页码：1578-1590 , 文章类型： Article，,卷期：2010年120-5]
- Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-M7, typically have a small, uncharged amino acid residue a...
- STRAD alpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
[作者：Orlova, KA; Parker, WE; Heuer, GG; Tsai, V; Yoon, J; Baybis, M; Fenning, RS; Strauss, K; Crino, PB,期刊：Journal of clinical investigation, 页码：1591-1602 , 文章类型： Article，,卷期：2010年120-5]
- Polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE) is a rare human autosomal-recessive disorder characterized by abnormal brain development, cognitive disability, and intractable epilepsy. It is cau...
- Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation
[作者：Iskandar, BJ; Rizk, E; Meier, B; Hariharan, N; Bottiglieri, T; Finnell, RH; Jarrard, DF; Banerjee, RV; Skene, JHP; Nelson, A; Patel, N; Gherasim, C; Simon, K; Cook, TD; Hogan, KJ,期刊：Journal of clinical investigation, 页码：1603-1616 , 文章类型： Article，,卷期：2010年120-5]
- The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combi...
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