- Antitumorigenic effects of a mutant of the heparin affin regulatory peptide on the U87 MG glioblastoma cell line
[作者:Dos Santos, C; Karaky, R; Renoir, D; Hamma-Kourbali, Y; Albanese, P; Gobbo, E; Griscelli, F; Opolon, P; Dalle, S; Perricaudet, M; Courty, J; Delbe, J,期刊:International Journal of Cancer, 页码:1038-1051 , 文章类型: Article,,卷期:2010年127-5]
- Glioblastoma is the most common primary brain tumor in human adults. Since existing treatments are not effective enough, novel therapeutic targets must be sought. The heparin-binding growth factor, heparin affin regulato...
- Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor
[作者:Hatakeyama, S; Kyan, A; Yamamoto, H; Okamoto, A; Sugiyama, N; Suzuki, Y; Yoneyama, T; Hashimoto, Y; Koie, T; Yamada, S; Saito, H; Arai, Y; Fukuda, M; Ohyama, C,期刊:International Journal of Cancer, 页码:1052-1059 , 文章类型: Article,,卷期:2010年127-5]
- We studied orchiectomy specimens from 130 patients immuhistochemically with testicular germ cell tumor (TGCT) using anti-core 2 N-acetylglucosaminyltransferase-1 (C2GnT-1) antibody. The incidence of C2GnT-1 positivity in...
- TGF-beta inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer
[作者:Baek, JY; Morris, SM; Campbell, J; Fausto, N; Yeh, MM; Grady, WM,期刊:International Journal of Cancer, 页码:1060-1071 , 文章类型: Article,,卷期:2010年127-5]
- Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their dow...
- Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X-L in colorectal cancer cells
[作者:Nakano, H; Miyazawa, T; Kinoshita, K; Yamada, Y; Yoshida, T,期刊:International Journal of Cancer, 页码:1072-1080 , 文章类型: Article,,卷期:2010年127-5]
MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate expression of target mRNA. They are involved in many biological processes, including cell proliferation, apoptosis and differentiation, a...
- The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis
[作者:Rothmeier, AS; Schneiders, UM; Wiedmann, RM; Ischenko, I; Bruns, CJ; Rudy, A; Zahler, S; Vollmar, AM,期刊:International Journal of Cancer, 页码:1096-1105 , 文章类型: Article,,卷期:2010年127-5]
- Treatment of pancreatic cancer remains a major challenge and new anticancer drugs are urgently required. Our study presents the marine natural compound spongistatin 1 as a promising experimental drug. Spongistatin 1 was ...
- miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer
[作者:Wada, R; Akiyama, Y; Hashimoto, Y; Fukamachi, H; Yuasa, Y,期刊:International Journal of Cancer, 页码:1106-1114 , 文章类型: Article,,卷期:2010年127-5]
- To clarify the role of micro (mi) RNAs in gastric carcinogenesis, we studied the expression and function of miRNAs in gastric carcinoma (GC) cells. Initially, we performed microarray analysis using total RNA from 3 human...
- IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort
[作者:Verheus, M; Maskarinec, G; Woolcott, CG; Haiman, CA; Le Marchand, L; Henderson, BE; Cheng, I; Kolonel, LN,期刊:International Journal of Cancer, 页码:1115-1123 , 文章类型: Article,,卷期:2010年127-5]
- Insulin-like growth factor-I (IGF-I) has mitogenic properties and stimulates cell growth. In this analysis, we investigated the relation between common genetic variation in IGF1, IGFBP1, and IGFBP3, and mammographic dens...
- Nucleophosmin is recognized by a cytotoxic T cell line derived from a rectal carcinoma patient
[作者:Swoboda, RK; Somasundaram, R; Caputo, L; Berencsi, K; von Franzke, P; Taylor, DD; Marincola, FM; Meropol, NJ; Sigurdson, E; Miller, E; Herlyn, D,期刊:International Journal of Cancer, 页码:1124-1130 , 文章类型: Article,,卷期:2010年127-5]
- Immunotherapy of colorectal carcinoma (CRC) has great promise as the presence of T lymphocytes in CRC tissues in situ is correlated with reduced recurrence and increased survival. Thus, identification of the antigens rec...
- Regulatory T cells control macrophage accumulation and activation in lymphoma
[作者:Galani, IE; Wendel, M; Stojanovic, A; Jesiak, M; Muller, MM; Schellack, C; Suri-Payer, E; Cerwenka, A,期刊:International Journal of Cancer, 页码:1131-1140 , 文章类型: Article,,卷期:2010年127-5]
- Strategies of manipulating immunosuppressive regulatory T cells (Treg) in cancer patients are currently evaluated in clinical trials. Treg suppress immune responses of tumor-specific T cells; yet, relatively little is kn...
- Transient depletion of CD4(+) T cells augments IL-21-based immunotherapy of disseminated neuroblastoma in syngeneic mice
[作者:Croce, M; Corrias, MV; Orengo, AM; Brizzolara, A; Carlini, B; Borghi, M; Rigo, V; Pistoia, V; Ferrini, S,期刊:International Journal of Cancer, 页码:1141-1150 , 文章类型: Article,,卷期:2010年127-5]
- IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic...
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