- Hedgehog controls neural stem cells through p53-independent regulation of Nanog
[作者:Po, A; Ferretti, E; Miele, E; De Smaele, E; Paganelli, A; Canettieri, G; Coni, S; Di Marcotullio, L; Biffoni, M; Massimi, L; Di Rocco, C; Screpanti, I; Gulino, A,期刊:EMBO journal, 页码:2646-2658 , 文章类型: Article,,卷期:2010年29-15]
- Hedgehog (Hh) pathway has a pivotal function in development and tumorigenesis, processes sustained by stem cells (SCs). The transcription factor Nanog controls stemness acting as a key determinant of both embryonic SC se...
- NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
[作者:Zbinden, M; Duquet, A; Lorente-Trigos, A; Ngwabyt, SN; Borges, I; Altaba, ARI,期刊:EMBO journal, 页码:2659-2674 , 文章类型: Article,,卷期:2010年29-15]
- A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG, are expressed in a number of human cancers. They form an ES-like signature we first described in glioblastoma multiforme (GBM), a hig...
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