- Generation of Dopamine Neurons with Improved Cell Survival and Phenotype Maintenance Using a Degradation-Resistant Nurr1 Mutant
[作者:Jo, AY; Kim, MY; Lee, HS; Rhee, YH; Lee, JE; Baek, KH; Park, CH; Koh, HC; Shin, I; Lee, YS; Lee, SH,期刊:Stem Cells, 页码:2238-2246 , 文章类型: Article,,卷期:2009年27-9]
- Nurr1 is a transcription factor specific for the development and maintenance of the midbrain dopamine (DA) neurons. Exogenous Nurr1 in neural precursor (NP) cells induces the differentiation of DA neurons in vitro that a...
- Adiponectin Stimulates Osteoblast Differentiation Through Induction of COX2 in Mesenchymal Progenitor Cells
[作者:Lee, HW; Kim, SY; Kim, AY; Lee, EJ; Choi, JY; Kim, JB,期刊:Stem Cells, 页码:2254-2262 , 文章类型: Article,,卷期:2009年27-9]
- In bone marrow, osteoblasts and adipocytes are differentiated from mesenchymal progenitor cells and their differentiation is reciprocally regulated by largely unknown mechanisms. In this study, we investigated downstream...
- National Heart, Lung, and Blood Institute Perspective: Lung Progenitor and Stem Cells-Gaps in Knowledge and Future Opportunities
[作者:Blaisdell, CJ; Gail, DB; Nabel, EG,期刊:Stem Cells, 页码:2263-2270 , 文章类型: Article,,卷期:2009年27-9]
- Because the lung stem cell field is so new, there remain many unanswered questions that are being addressed regarding the identification, location, and role of exogenous and endogenous stem and progenitor cell population...
- p38 MAP Kinase Inhibits Neutrophil Development Through Phosphorylation of C/EBP alpha on Serine 21
[作者:Geest, CR; Buitenhuis, M; Laarhoven, AG; Bierings, MB; Bruin, MCA; Vellenga, E; Coffer, PJ,期刊:Stem Cells, 页码:2271-2282 , 文章类型: Article,,卷期:2009年27-9]
- Many extracellular stimuli regulate growth, survival, and differentiation responses through activation of the dual specificity mitogen activated protein kinase ( MAPK) kinase three (MKK3) and its downstream effector p38 ...
- Mesenchymal Stem Cells Pretreated with Delivered Hph-1-Hsp70 Protein Are Protected from Hypoxia-Mediated Cell Death and Rescue Heart Functions from Myocardial Injury
[作者:Chang, W; Song, BW; Lim, S; Song, H; Shim, CY; Cha, MJ; Ahn, DH; Jung, YG; Lee, DH; Chung, JH; Choi, KD; Lee, SK; Chung, N; Lee, SK; Jang, Y; Hwang, KC,期刊:Stem Cells, 页码:2283-2292 , 文章类型: Article,,卷期:2009年27-9]
- Mesenchymal stem cell (MSC) therapy for myocardial injury has inherent limitations due to the poor viability of MSCs after cell transplantation. In this study, we directly delivered Hsp70, a protein with protective funct...
- Fibroblastic Colony-Forming Unit Bone Marrow Cells Delay Progression to Gastric Dysplasia in a Helicobacter Model of Gastric Tumorigenesis
[作者:Wang, SSW; Asfaha, S; Okumura, T; Betz, KS; Muthupalani, S; Rogers, AB; Tu, SP; Takaishi, S; Jin, GC; Yang, XD; Wu, DC; Fox, JG; Wang, TC,期刊:Stem Cells, 页码:2301-2311 , 文章类型: Article,,卷期:2009年27-9]
- Bone marrow mesenchymal stem cells (MSCs) have been shown to have immune modulatory effects. Despite efforts to identify these cells in vivo, to date, MSCs have been defined mainly by their in vitro cell characteristics....
- Medicine on the Fringe: Stem Cell-Based Interventions in Advance of Evidence
[作者:Regenberg, AC; Hutchinson, LA; Schanker, B; Mathews, DJH,期刊:Stem Cells, 页码:2312-2319 , 文章类型: Article,,卷期:2009年27-9]
- Stem cell-based interventions (SCBIs) offer great promise; however, there is currently little internationally accepted, scientific evidence supporting the clinical use of SCBIs. The consensus within the scientific commun...
- Human Bone Marrow-Derived Mesenchymal Stromal Cells Expressing S-TRAIL as a Cellular Delivery Vehicle for Human Glioma Therapy
[作者:Menon, LG; Kelly, K; Yang, HW; Kim, SK; Black, PM; Carroll, RS,期刊:Stem Cells, 页码:2320-2330 , 文章类型: Article,,卷期:2009年27-9]
- Glioblastoma is among the most aggressive and treatment resistant of all human cancers. Conventional therapeutic approaches are unsuccessful because of diffuse infiltrative invasion of glioma tumor cells into normal brai...
- Human Alternatives to Fetal Bovine Serum for the Expansion of Mesenchymal Stromal Cells from Bone Marrow
[作者:Bieback, K; Hecker, A; Kocaomer, A; Lannert, H; Schallmoser, K; Strunk, D; Kluter, H,期刊:Stem Cells, 页码:2331-2341 , 文章类型: Article,,卷期:2009年27-9]
- Mesenchymal stromal cells (MSCs) are promising candidates for novel cell therapeutic applications. For clinical scale manufacturing, human factors from serum or platelets have been suggested as alternatives to fetal bovi...
- Adenoviral-Mediated Endothelial Precursor Cell Delivery of Soluble CD115 Suppresses Human Prostate Cancer Xenograft Growth in Mice
[作者:Lucas, T; Abraham, D; Untergasser, G; Zins, K; Hofer, E; Gunsilius, E; Aharinejad, S,期刊:Stem Cells, 页码:2342-2352 , 文章类型: Article,,卷期:2009年27-9]
- Prostate cancer tumor growth and neovascularization is promoted by an interplay between migratory tumor stromal cells such as specialized tumor-associated macrophages (TAMs) and circulating endothelial precursor cells (C...
- Evaluating Erythropoietin-Associated Tumor Progression Using Archival Tissues from a Phase III Clinical Trial
[作者:Miller, CP; Lowe, KA; Valliant-Saunders, K; Kaiser, JF; Mattern, D; Urban, N; Henke, M; Blau, CA,期刊:Stem Cells, 页码:2353-2361 , 文章类型: Article,,卷期:2009年27-9]
- Despite the prevalence of anemia in cancer, recombinant erythropoietin (Epo) has declined in use because of recent Phase III trials showing more rapid cancer progression and reduced survival in subjects randomized to Epo...
- Neural Stem Cell Transplantation Benefits a Monogenic Neurometabolic Disorder During the Symptomatic Phase of Disease
[作者:Jeyakumar, M; Lee, JP; Sibson, NR; Lowe, JP; Stuckey, DJ; Tester, K; Fu, G; Newlin, R; Smith, DA; Snyder, EY; Platt, FM,期刊:Stem Cells, 页码:2362-2370 , 文章类型: Article,,卷期:2009年27-9]
- Although we and others have demonstrated that neural stem cells (NSCs) may impact such neurogenetic conditions as lysosomal storage diseases when transplanted at birth, it has remained unclear whether such interventions ...
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
[作者:Kurrey, NK; Jalgaonkar, SP; Joglekar, AV; Ghanate, AD; Chaskar, PD; Doiphode, RY; Bapat, SA,期刊:Stem Cells, 页码:2059-2068 , 文章类型: Article,,卷期:2009年27-9]
- The transcriptional repressors Snail and Slug contribute to cancer progression by mediating epithelial-mesenchymal transition (EMT), which results in tumor cell invasion and metastases. We extend this current understandi...
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