- Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase
[作者:Whittingham, JL; Carrero-Lerida, J; Brannigan, JA; Ruiz-Perez, LM; Silva, APG; Fogg, MJ; Wilkinson, AJ; Gilbert, IH; Wilson, KS; Gonzalez-Pacanowska, D,期刊:Biochemical Journal, 页码:499-509 , 文章类型: Article,,卷期:2010年428-Part 3]
- Plasmodium falciparum is the causative agent of malaria, a disease where new drug targets are required due to increasing resistance to current anti-malarials. TMPK (thymidylate kinase) is a good candidate as it is essent...
- The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment
[作者:Antalis, TM; Buzza, MS; Hodge, KM; Hooper, JD; Netzel-Arnett, S,期刊:Biochemical Journal, 页码:325-346 , 文章类型: Review,,卷期:2010年428-Part 3]
- The serine proteases of the trypsin-like (S 1) family play critical roles in many key biological processes including digestion, blood coagulation, and immunity. Members of this family contain N- or C-terminal domains tha...
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