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  • Mutation Analysis of Hypoxia-inducible Factors HIF1A and HIF2A in Renal Cell Carcinoma
    [作者:Morris, MR; Hughes, DJ; Tian, YM; Ricketts, CJ; Lau, KW; Gentle, D; Shuib, S; Serrano-Fernandez, P; Lubinski, J; Wiesener, MS; Pugh, CW; Latif, F; Ratcliffe, PJ; Maher, ER,期刊:Anticancer Research, 页码:4337-4343 , 文章类型: Article,,卷期:2009年29-11]
  • Background: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1 alpha and -2 alpha is a critical event in the pathogenesis of mo...