- Establishment and Characterization of Multidrug-resistant Gastric Cancer Cell Lines
[作者:Zhang, XT; Yashiro, M; Qiu, H; Nishii, T; Matsuzaki, T; Hirakawa, K,期刊:Anticancer Research, 页码:915-921 , 文章类型: Article,,卷期:2010年30-3]
- Aim: The aim of this study was to establish drug-resistant cell lines and to elucidate mechanisms leading to multi-drug resistance in gastric cancer. Materials and Methods: Five cancer cell lines resistant to 5-fluoroura...
- 3-Bromopyruvate Induces Endoplasmic Reticulum Stress, Overcomes Autophagy and Causes Apoptosis in Human HCC Cell Lines
[作者:Ganapathy-Kanniappan, S; Geschwind, JFH; Kunjithapatham, R; Buijs, M; Syed, LH; Rao, PP; Ota, S; Kwak, BK; Loffroy, R; Vali, M,期刊:Anticancer Research, 页码:923-935 , 文章类型: Article,,卷期:2010年30-3]
Background: Autophagy, a cellular response to stress, plays a role in resistance to chemotherapy in cancer cells. Resistance renders systemic chemotherapy generally ineffective against human hepatocellular carcinoma (...
- Emodin, Aloe-emodin and Rhein Induced DNA Damage and Inhibited DNA Repair Gene Expression in SCC-4 Human Tongue Cancer Cells
[作者:Chen, YY; Chiang, SY; Lin, JG; Yang, JS; Ma, YS; Liao, CL; Lai, TY; Tang, NY; Chung, JG,期刊:Anticancer Research, 页码:945-951 , 文章类型: Article,,卷期:2010年30-3]
- In our primary studies, we have shown that emodin, aloe-emodin and rhein induced cytotoxic effects, including cell cycle arrest and apoptosis in SCC-4 human tongue cancer cells. However, details regarding their effects o...
- Pattern of Failure Following Chemoradiation for Locally Advanced Non-small Cell Lung Cancer: Potential Role for Stereotactic Body Radiotherapy
[作者:Nguyen, NP; Bishop, M; Borok, TJ; Welsh, J; Hamilton, R; Cohen, D; Nguyen, LM; Vincent, VH,期刊:Anticancer Research, 页码:953-961 , 文章类型: Article,,卷期:2010年30-3]
- Standard of care for locally advanced non-small cell lung cancer has been concurrent chemoradiation. However, optimal chemotherapy regimen, radiation therapy dose and treatment volume have not been clearly defined despit...
- Severe Intoxication with Methotrexate Possibly Associated with Concomitant Use of Proton Pump Inhibitors
[作者:Santucci, R; Leveque, D; Kemmel, V; Lutz, P; Gerout, AC; N'guyen, A; Lescoute, A; Schneider, F; Bergerat, JP; Herbrecht, R,期刊:Anticancer Research, 页码:963-965 , 文章类型: Article,,卷期:2010年30-3]
- Background: Delayed elimination of methotrexate associated with serious side-effects has been attributed to the co-administration of benzimidazole proton pump inhibitors. Patients and Methods: We have retrospectively ana...
- Acute Promyelocytic Leukemia in Patients Aged Over 60 Years: Multicenter Experience of 34 Consecutive Unselected Patients
[作者:Ferrara, F; Finizio, O; D'Arco, A; Mastrullo, L; Cantore, N; Musto, P,期刊:Anticancer Research, 页码:967-971 , 文章类型: Article,,卷期:2010年30-3]
- Treatment of acute promyelocytic leukemia (APL) has evolved over recent years, resulting in a cure rate of 75-80%. However, the prognosis of older patients with APL remains poorer as compared to young adults because of s...
- Serious Hematologic Complications Following Erlotinib Treatment
[作者:Stathopoulos, GP; Trafalis, D; Athanasiou, A; Bardi, G; Chandrinou, H,期刊:Anticancer Research, 页码:973-976 , 文章类型: Article,,卷期:2010年30-3]
- Background: Erlotinib is an oral, small-molecule targeting therapy which inhibits epidermal growth factor tyrosine kinase receptors. Erlotinib has been administered for the treatment of advanced pancreatic cancer and non...
- MMP Inhibition Blocks Fibroblast-dependent Skin Cancer Invasion, Reduces Vascularization and Alters VEGF-A and PDGF-BB Expression
[作者:Woenne, EC; Lederle, W; Zwick, S; Palmowski, M; Krell, H; Semmler, W; Mueller, MM; Kiessling, F,期刊:Anticancer Research, 页码:703-711 , 文章类型: Article,,卷期:2010年30-3]
- Tumor invasion requires intense interactions with stromal cells and a profound extracellular matrix remodelling by matrix metalloproteinases (MMPs). Here, we assessed the specific contribution of fibroblasts to tumor inv...
- Expression of KISS1 and MMP-9 in Non-small Cell Lung Cancer and Their Relations to Metastasis and Survival
[作者:Zheng, SQ; Chang, YH; Hodges, KB; Sun, Y; Ma, XB; Xueyi; Williamson, SR; Lopez-Beltran, A; Montironi, R; Cheng, L,期刊:Anticancer Research, 页码:713-718 , 文章类型: Article,,卷期:2010年30-3]
- KISS1 and matrix metalloproteinase-9 (MMP-9) may play important roles as metastasis suppressor and metastasis promoter genes, respectively, in a variety of malignancies. However, there is little information about their p...
- Mutations of PTEN Gene in Gliomas Correlate to Tumor Differentiation and Short-term Survival Rate
[作者:Yang, YL; Shao, NY; Luo, GH; Li, L; Zheng, L; Nilsson-Ehle, P; Xu, N,期刊:Anticancer Research, 页码:981-985 , 文章类型: Article,,卷期:2010年30-3]
- The present study determined mutations of phosphatase and tensin homolog (PTEN) gene in patients suffering from high-grade gliomas (WHO grades III and IV) and further investigated the mutations in correlation to patients...
- Characterization of Prostate Cancer in Needle Biopsy by Cathepsin B, Cell Proliferation and DNA Ploidy
[作者:Qian, JQ; Bostwick, DG; Iczkowski, KA; Betre, K; Wilson, MJ; Le, C; Sinha, AA,期刊:Anticancer Research, 页码:719-725 , 文章类型: Article,,卷期:2010年30-3]
- Background: Our objective was to determine localization patterns of three distinct groups of biomarkers (cathepsin B, MIB-1 and DNA ploidy) in prostate needle biopsy sections to establish localization similarities (or di...
- Molecular Characterization of Invasive Subpopulations from an Esophageal Squamous Cell Carcinoma Cell Line
[作者:Chen, YK; Chang, WSW; Wu, IC; Li, LH; Yang, SF; Chen, JYF; Hsu, MC; Cheni, SH; Wu, DC; Lee, JM; Huang, CH; Goan, YG; Chou, SH; Huang, CT; Wu, MT,期刊:Anticancer Research, 页码:727-736 , 文章类型: Article,,卷期:2010年30-3]
- Background: Once diagnosed, esophageal cancer has a very low overall 5-year survival rate. This study investigates the mechanisms behind the invasiveness and severity of esophageal squamous cell carcinoma (ESCC). Materia...
- Effects of Preoperative Immunochemoradiotherapy and Chemoradiotherapy on Immune Responses in Patients with Rectal Adenocarcinoma
[作者:Sadahiro, S; Suzuki, T; Maeda, Y; Tanaka, A; Kamijo, A; Murayama, C; Nakayama, Y; Akiba, T,期刊:Anticancer Research, 页码:993-999 , 文章类型: Article,,卷期:2010年30-3]
- Background: We previously reported that preoperative chemoradiotherapy (CRT) combined with intraoperative electron irradiation for cT3/T4 adenocarcinoma of the rectum reduced the local recurrence, with significant improv...
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