- Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1 beta and Tumor Necrosis Factor-alpha Effects on Extracellular Signal-Regulated Kinase Activation and Lipolysis
[作者：Jager, J; Gremeaux, T; Gonzalez, T; Bonnafous, S; Debard, C; Laville, M; Vidal, H; Tran, A; Gual, P; Le Marchand-Brustel, Y; Cormont, M; Tanti, JF,期刊：Diabetes, 页码：61-70 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Activation of extracellular signal-regulated kinase-(ERK)-1/2 by cytokines in adipocytes is involved in the alterations of adipose tissue functions participating in insulin resistance. This study aims at, ident...
- High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice
[作者：Qiu, BY; Turner, N; Li, YY; Gu, M; Huang, MW; Wu, F; Pang, T; Nan, FJ; Ye, JM; Li, JY; Li, J,期刊：Diabetes, 页码：256-265 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Recently, several drugs have been shown to exert beneficial effects for metabolic syndrome through mad regulation of mitochondrial function. Hence, we explored a strategy of targeting mitochondrial function to ...
- Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes
[作者：Allen, HL; Johansson, S; Ellard, S; Shields, B; Hertel, JK; Raeder, H; Colclough, K; Molven, A; Frayling, TM; Njolstad, PR; Hattersley, AT; Weedon, MN,期刊：Diabetes, 页码：266-271 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is ca...
- Sympathetic Neural Adaptation to Hypocaloric Diet With or Without Exercise Training in Obese Metabolic Syndrome Subjects
[作者：Straznicky, NE; Lambert, EA; Nestel, PJ; McGrane, MT; Dawood, T; Schlaich, MP; Masuo, K; Eikelis, N; de Courten, B; Mariani, JA; Esler, MD; Socratous, F; Chopra, R; Sari, CI; Paul, E; Lambert, GW,期刊：Diabetes, 页码：71-79 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Sympathetic nervous system (SNS) overactivity contributes to the pathogenesis and target organ complications of obesity. This study was conducted to examine the effects of lifestyle interventions (weight loss a...
- Idd9.1 Locus Controls the Suppressive Activity of FoxP3(+)CD4(+)CD25(+) Regulatory T-Cells
[作者：Yamanouchi, J; Puertas, MC; Verdaguer, J; Lyons, PA; Rainbow, DB; Chamberlain, G; Hunter, KM; Peterson, LB; Wicker, LS; Santamaria, P,期刊：Diabetes, 页码：272-281 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-The similar to 45-cM insulin-dependent diabetes 9 (Idd9) region on mouse chromosome 4 harbors several different type I diabetes-associated loci. Nonobese diabetic (NOD) mice congenic for the Idd9 region of C57B...
- Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19(Delta 13)
[作者：Petry, CJ; Evans, ML; Wingate, DL; Ong, KK; Reik, W; Constancia, M; Dunger, DB,期刊：Diabetes, 页码：282-286 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-We have hypothesized that variation in imprinted growth-promoting fetal genes may affect maternal glucose concentrations in pregnancy. To test this hypothesis we evaluated the effects of fetal disruption of mur...
- Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
[作者：Coen, PM; Dube, JJ; Amati, F; Stefanovic-Racic, M; Ferrell, RE; Toledo, FGS; Goodpaster, BH,期刊：Diabetes, 页码：80-88 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-We tested the primary hypotheses that sphingolipid and diacylglycerol (DAG) content is higher within insulin-resistant muscle and that the association between intramyocellular triglycerides (IMTG) and insulin r...
- Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
[作者：'t Hart, LM; Simonis-Bik, AM; Nijpels, G; van Haeften, TW; Schafer, SA; Houwing-Duistermaat, JJ; Boomsma, DI; Groenewoud, MJ; Reiling, E; van Hove, EC; Diamant, M; Kramer, MHH; Heine, RJ; Maassen, JA; Kirchhoff, K; Machicao, F; Haring, HU; Slagboom, PE; Willemsen, G; Eekhoff, EM; de Geus, EJ; Dekker, JM; Fritsche, A,期刊：Diabetes, 页码：287-292 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered beta-cell function. In this study, we have investigated the combined effects of eight known beta-cell ...
- Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic beta-Cell Function
[作者：Simonis-Bik, AM; Nijpels, G; van Haeften, TW; Houwing-Duistermaat, JJ; Boomsma, DI; Reiling, E; van Hove, EC; Diamant, M; Kramer, MHH; Heine, RJ; Maassen, JA; Slagboom, PE; Willemsen, G; Dekker, JM; Eekhoff, EM; de Geus, EJ; 't Hart, LM,期刊：Diabetes, 页码：293-301 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin...
- Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function
[作者：Karakelides, H; Irving, BA; Short, KR; O'Brien, P; Nair, KS,期刊：Diabetes, 页码：89-97 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Reductions in insulin sensitivity in conjunction with muscle mitochondrial dysfunction have been reported to occur in many conditions including aging. The objective was to determine whether insulin resistance a...
- Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals
[作者：Meyre, D; Proulx, K; Kawagoe-Takaki, H; Vatin, V; Gutierrez-Aguilar, R; Lyon, D; Ma, M; Choquet, H; Horber, F; Van Hul, W; Van Gaal, L; Balkau, B; Visvikis-Siest, S; Pattou, F; Farooqi, IS; Saudek, V; O'Rahilly, S; Froguel, P; Sedgwick, B; Yeo, GSH,期刊：Diabetes, 页码：311-318 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Single nucleotide polymorphisms (SNPs) in intron I of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to ...
- Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity Probable Underlying Mechanisms
[作者：Padmavathi, IJN; Rao, KR; Venu, L; Ganeshan, M; Kumar, KA; Rao, CN; Harishankar, N; Ismail, A; Raghunath, M,期刊：Diabetes, 页码：98-104 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-We demonstrated previously that chronic maternal micronutrient restriction altered the body composition in rat offspring and may predispose offspring to adult-onset diseases. Chromium (Cr) regulates glucose and...
- Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
[作者：Arner, E; Westermark, PO; Spalding, KL; Britton, T; Ryden, M; Frisen, J; Bernard, S; Arner, P,期刊：Diabetes, 页码：105-109 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology. RESEARCH DESIGN AND METHODS-Su...
- Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats Prevention of Diabetes by Maternal Immunization
[作者：Tirabassi, RS; Guberski, DL; Blankenhorn, EP; Leif, JH; Woda, BA; Liu, ZJ; Winans, D; Greiner, DL; Mordes, JP,期刊：Diabetes, 页码：110-118 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-The contribution of antecedent viral infection to the development of type 1 diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) identify viruses capable of modulating di...
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