- GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
[作者：Lundgren, VM; Isomaa, B; Lyssenko, V; Laurila, E; Korhonen, P; Groop, LC; Tuomi, T,期刊：Diabetes, 页码：416-422 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS-GADAs were analyzed in 4,976 n...
- Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette
[作者：Driver, JP; Scheuplein, F; Chen, YG; Grier, AE; Wilson, SB; Serreze, DV,期刊：Diabetes, 页码：423-432 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-In part, activation of invariant natural killer T (iNKT)-cells with the superagonist a-galactosylceramide (alpha-Gal-Cer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by in...
- Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant
[作者：Gagliani, N; Jofra, T; Stabilini, A; Valle, A; Atkinson, M; Roncarolo, MG; Battaglia, M,期刊：Diabetes, 页码：433-439 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-In type 1 diabetes, allogeneic pancreatic islet transplant restores insulin production, but life-threatening immunosuppression is required to avoid graft rejection. Induction of antigen (Ag)-specific tolerance ...
- Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated beta-Cell Death
[作者：Chen, JQ; Fontes, G; Saxena, G; Poitout, V; Shalev, A,期刊：Diabetes, 页码：440-447 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-We have previously shown that lack of thioredoxin-interacting protein (TXNIP) protects against diabetes and glucotoxicity-induced beta-cell apoptosis. Because the role of TXNIP in lipotoxicity is unknown, the g...
- Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic beta-Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death
[作者：Wei, D; Li, J; Shen, MD; Jia, W; Chen, NQ; Chen, T; Su, DM; Tian, HM; Zheng, SS; Dai, YF; Zhao, A,期刊：Diabetes, 页码：471-478 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-To evaluate the direct impact of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the functions and viability of pancreatic beta-cells. RESEARCH DESIGN AND METHODS-We developed an mfat-1 transgenic mouse model in...
- TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action
[作者：Villareal, DT; Robertson, H; Bell, GI; Patterson, BW; Tran, H; Wice, B; Polonsky, KS,期刊：Diabetes, 页码：479-485 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 di...
- Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies
[作者：Cardwell, CR; Stene, LC; Joner, G; Bulsara, MK; Cinek, O; Rosenbauer, J; Ludvigsson, J; Jane, M; Svensson, J; Goldacre, MJ; Waldhoer, T; Jarosz-Chobot, P; Gimeno, SGA; Chuang, LM; Parslow, RC; Wadsworth, EJK; Chetwynd, A; Pozzilli, P; Brigis, G; Urbonaite, B; Sipetic, S; Schober, E; Devoti, G; Ionescu-Tirgoviste, C; de Beaufort, CE; Stoyanov, D; Buschard, K; Patterson, CC,期刊：Diabetes, 页码：486-494 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adju...
- Duration of Lactation and Incidence of the Metabolic Syndrome in Women of Reproductive Age According to Gestational Diabetes Mellitus Status: A 20-Year Prospective Study in CARDIA (Coronary Artery Risk Development in Young Adults)
[作者：Gunderson, EP; Jacobs, DR; Chiang, V; Lewis, CE; Feng, JR; Quesenberry, CP; Sidney, S,期刊：Diabetes, 页码：495-504 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The objective of the study was to prospectively assess the association between lactation duration and incidence of the metabolic syndrome among women of reproductive age. RESEARCH DESIGN AND METHODS-Participant...
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