- Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes
[作者:Albu, JB; Heilbronn, LK; Kelley, DE; Smith, SR; Azuma, K; Berk, ES; Pi-Sunyer, FX; Ravussin, E,期刊:Diabetes, 页码:627-633 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-To characterize the relationships among long-term improvements in peripheral insulin sensitivity (glucose disposal rate [GDR]), fasting glucose, and free fatty acids (FFAs) and concomitant changes in weight and...
- CD14(+) Monocytes Are Vulnerable and Functionally Impaired Under Endoplasmic Reticulum Stress in Patients With Type 2 Diabetes
[作者:Komura, T; Sakai, Y; Honda, M; Takamura, T; Matsushima, K; Kaneko, S,期刊:Diabetes, 页码:634-643 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-Although patients with diabetes suffer from increased infections and a higher incidence of cancer due to impaired immune function, details on diabetes-induced decrease in immunity are lacking. We assessed how i...
- Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
[作者:McKenzie, MD; Jamieson, E; Jansen, ES; Scott, CL; Huang, DCS; Bouillet, P; Allison, J; Kay, TWH; Strasser, A; Thomas, HE,期刊:Diabetes, 页码:644-652 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-High concentrations of circulating glucose are believed to contribute to defective insulin secretion and beta-cell function in diabetes and at least some of this effect appears to be caused by glucose-induced b...
- Insulin Gene Mutations Resulting in Early-Onset Diabetes: Marked Differences in Clinical Presentation, Metabolic Status, and Pathogenic Effect Through Endoplasmic Reticulum Retention
[作者:Meur, G; Simon, A; Harun, N; Virally, M; Dechaume, A; Bonnefond, A; Fetita, S; Tarasov, AI; Guillausseau, PJ; Boesgaard, TW; Pedersen, O; Hansen, T; Polak, M; Gautier, JF; Froguel, P; Rutter, GA; Vaxillaire, M,期刊:Diabetes, 页码:653-661 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-Heterozygous mutations in the human preproinsulin (INS) gene are a cause of nonsyndromic neonatal or early-infancy diabetes. Here, we sought to identify INS mutations associated with maturity-onset diabetes of ...
- Hyperglycemia Impairs Proteasome Function by Methylglyoxal
[作者:Queisser, MA; Yao, DC; Geisler, S; Hammes, HP; Lochnit, G; Schleicher, ED; Brownlee, M; Preissner, KT,期刊:Diabetes, 页码:670-678 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MG...
- Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes-Mediated Mammary Tumor Progression
[作者:Fierz, Y; Novosyadlyy, R; Vijayakumar, A; Yakar, S; LeRoith, D,期刊:Diabetes, 页码:686-693 , 文章类型: Proceedings Paper,,卷期:2010年59-3]
- OBJECTIVE-Type 2 diabetes increases breast cancer risk and mortality, and hyperinsulinemia has been identified as a major factor linking these two diseases. Thus, we hypothesized that pharmacological reduction of elevate...
- Increased Vitreous Shedding of Microparticles in Proliferative Diabetic Retinopathy Stimulates Endothelial Proliferation
[作者:Chahed, S; Leroyer, AS; Benzerroug, M; Gaucher, D; Georgescu, A; Picaud, S; Silvestre, JS; Gaudric, A; Tedgui, A; Massin, P; Boulanger, CM,期刊:Diabetes, 页码:694-701 , 文章类型: Article,,卷期:2010年59-3]
- OBJECTIVE-Diabetic retinopathy is associated with progressive retinal capillary activation and proliferation, leading to vision impairment and blindness. Microparticles are submicron membrane vesicles with biological act...
|