- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
[作者：Houde, VP; Brule, S; Festuccia, WT; Blanchard, PG; Bellmann, K; Deshaies, Y; Marette, A,期刊：Diabetes, 页码：1338-1348 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-The mammalian target of rapamycin (mTOR)/p70 S6 kinase 1 (S6K1) pathway is a critical signaling component in the development of obesity-linked insulin resistance and operates a nutrient-sensing negative feedbac...
- Mechanisms of Insulin Resistance After Insulin-Induced Hypoglycemia in Humans: The Role of Lipolysis
[作者：Lucidi, P; Rossetti, P; Porcellati, F; Pampanelli, S; Candeloro, P; Andreoli, AM; Perriello, G; Bolli, GB; Fanelli, CG,期刊：Diabetes, 页码：1349-1357 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Changes in glucose metabolism occurring during counterregulation are, in part, mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated lipolysis. However, it is not known whe...
- TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
[作者：An, D; Toyoda, T; Taylor, EB; Yu, HY; Fujii, N; Hirshman, MF; Goodyear, LJ,期刊：Diabetes, 页码：1358-1365 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the f...
- Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance
[作者：Koonen, DPY; Sung, MMY; Kao, CKC; Dolinsky, VW; Koves, TR; Ilkayeva, O; Jacobs, RL; Vance, DE; Light, PE; Muoio, DM; Febbraio, M; Dyck, JRB,期刊：Diabetes, 页码：1366-1375 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Although advanced age is a risk factor for type 2 diabetes, a clear understanding of the changes that occur during middle age that contribute to the development of skeletal muscle insulin resistance is currentl...
- Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice
[作者：Guo, H; Jin, DZ; Zhang, YY; Wright, W; Bazuine, M; Brockman, DA; Bernlohr, DA; Chen, XL,期刊：Diabetes, 页码：1376-1385 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Lipocalin (LCN) 2 belongs to the lipocalin subfamily of low-molecular mass-secreted proteins that bind small hydrophobic molecules. LCN2 has been recently characterized as an adipose-derived cytokine, and its e...
- Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo
[作者：Dong, YZ; Zhang, MA; Wang, SX; Liang, B; Zhao, ZX; Liu, C; Wu, MY; Choi, HC; Lyons, TJ; Zou, MH,期刊：Diabetes, 页码：1386-1396 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-...
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
[作者：Kumar, A; Lawrence, JC; Jung, DY; Ko, HJ; Keller, SR; Kim, JK; Magnuson, MA; Harris, TE,期刊：Diabetes, 页码：1397-1406 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphotylates and activates Akt, an insulin signaling intermediary that, regulates glucose and lipid me...
- Perwdsome Proliferator-Activated Receptor-gamma Coactivator-1 alpha Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals
[作者：Consitt, LA; Bell, JA; Koves, TR; Muoio, DM; Hulver, MW; Haynie, KR; Dohm, GL; Houmard, JA,期刊：Diabetes, 页码：1407-1415 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corre...
- Deletion of the alpha-Arrestin Protein Tymip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
[作者：Chutkow, WA; Birkenfeld, AL; Brown, JD; Lee, HY; Frederick, DW; Yoshioka, J; Patwari, P; Kursawe, R; Cushman, SW; Plutzky, J; Shulman, GI; Samuel, VT; Lee, RT,期刊：Diabetes, 页码：1424-1434 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Thioredoxin interacting protein (Txnip), a regulator of cellular oxidative stress, is induced by hyperglycemia and inhibits glucose uptake into fat and muscle, suggesting a role for Txnip in type 2 diabetes pat...
- Ectopic Expression of E2F1 Stimulates beta-Cell Proliferation and Function
[作者：Grouwels, G; Cai, Y; Hoebeke, I; Leuckx, G; Heremans, Y; Ziebold, U; Stange, G; Chintinne, M; Ling, ZD; Pipeleers, D; Heimberg, H; Van de Casteele, M,期刊：Diabetes, 页码：1435-1444 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Generating functional beta-cells by inducing their proliferation may provide new perspectives for cell therapy in diabetes. Transcription factor E2F1 controls G(1)- to S-phase transition during the cycling of m...
- Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
[作者：Tree, TIM; Lawson, J; Edwards, H; Skowera, A; Arif, S; Roep, BO; Peakman, M,期刊：Diabetes, 页码：1451-1460 , 文章类型： Article，,卷期：2010年59-6]
- OBJECTIVE-Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key mechanism in the maintenance of self-tolerance and protection from type 1 diabetes. To date, however, detailed information on such...
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