- Aliphatic Lipid Substitution on 2 kDa Polyethylenimine Improves Plasmid Delivery and Transgene Expression
[作者:Neamnark, A; Suwantong, O; Bahadur, KCR; Hsu, CYM; Supaphol, P; Uludag, H,期刊:Molecular Pharmaceutics, 页码:1798-1815 , 文章类型: Article,,卷期:2009年6-6]
This study was conducted in order to develop amphiphilic, low molecular weight polymeric carriers for nonviral gene delivery. Caprylic, myristic, palmitic, stearic, oleic and linoleic acids were grafted onto the 2 kDa...
- Efficient Delivery of Antisense Oligodeoxyribonucleotide G3139 by Human Serum Albumin-Coated Liposomes
[作者:Weecharangsan, W; Yu, B; Zheng, Y; Liu, SJ; Pang, JX; Lee, LJ; Marcucci, G; Lee, RJ,期刊:Molecular Pharmaceutics, 页码:1848-1855 , 文章类型: Article,,卷期:2009年6-6]
- Human serum albumin (HSA)-coated liposomal formulations were synthesized and evaluated for the delivery of antisense oligodeoxyribonucleotide (ODN) 63139 in KB human oral carcinoma cells. Liposomes composed of dimethyldi...
- The Role of P-Glycoprotein in Intestinal Transport versus the BBB Transport of Tetraphenylphosphonium
[作者:Swed, A; Eyal, S; Madar, I; Zohar-Kontante, H; Weiss, L; Hoffman, A,期刊:Molecular Pharmaceutics, 页码:1883-1890 , 文章类型: Article,,卷期:2009年6-6]
- Tetraphenylphosphonium (TPP), a phosphonium cation, is a promising means for tumor imaging. A major contributor to the pharmacokinetics of phosphonium cations is the efflux transporter P-glycoprotein (P-gp). For this app...
- Impact of Hydrogel Nanoparticle Size and Functionalization on In Vivo Behavior for Lung Imaging and Therapeutics
[作者:Liu, YJ; Ibricevic, A; Cohen, JA; Cohen, JL; Gunsten, SP; Frechet, JMJ; Walter, MJ; Welch, MJ; Brody, SL,期刊:Molecular Pharmaceutics, 页码:1891-1902 , 文章类型: Article,,卷期:2009年6-6]
- Polymer chemistry offers the possibility of synthesizing multifunctional nanoparticles which incorporate moieties that enhance diagnostic and therapeutic targeting of cargo delivery to the lung. However, since rules for ...
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