- Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway
[作者：List, K; Kosa, P; Szabo, R; Bey, AL; Wang, CB; Molinolo, A; Bugge, TH,期刊：American Journal of Pathology, 页码：1453-1463 , 文章类型： Article，,卷期：2009年175-4]
- A pericellular proteolytic pathway initiated by the transmembrane serine protease matriptase plays a critical role in the terminal differentiation of epidermal tissues. Matriptase is constitutively expressed in multiple ...
- Suppression of Activation and Costimulatory Signaling in Splenic CD4(+) T Cells after Trauma-Hemorrhage Reduces T-Cell Function A Mechanism of Post-Traumatic Immune Suppression
[作者：Hsieh, CH; Hsu, JT; Hsieh, YC; Frink, M; Raju, R; Hubbard, WJ; Bland, KI; Chaudry, IH,期刊：American Journal of Pathology, 页码：1504-1514 , 文章类型： Article，,卷期：2009年175-4]
- Reduced immune function is frequently a consequence of serious injury such as trauma-hemorrhage (T-H). Injury may lead to reduced T-cell activation, resulting in decreased engagement of costimulatory molecules after anti...
- An Inducible Cartilage Oligomeric Matrix Protein Mouse Model Recapitulates Human Pseudoachondroplasia Phenotype
[作者：Posey, KL; Veerisetty, AC; Liu, PM; Wang, HR; Poindexter, BJ; Bick, R; Alcorn, JL; Hecht, JT,期刊：American Journal of Pathology, 页码：1555-1563 , 文章类型： Article，,卷期：2009年175-4]
- Cartilage oligomeric matrix protein (COMP) is a pentameric extracellular protein expressed in cartilage and other musculoskeletal tissues. Mutations in the COMP gene cause pseudoachondroplasia (PSACH), a severe dwarfing ...
- The Effect of Plasma From Muscle-Specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates
[作者：ter Beek, WP; Martinez-Martinez, P; Losen, M; de Baets, MH; Wintzen, AR; Verschuuren, JJGM; Niks, EH; van Duinen, SG; Vincent, A; Molenaar, PC,期刊：American Journal of Pathology, 页码：1536-1544 , 文章类型： Article，,卷期：2009年175-4]
- Muscle-specific tyrosine kinase (MuSK) is essential for clustering of acetylcholine receptors (AChRs) at embryogenesis and likely also important for maintaining synaptic structure in adult muscle. In 5 to 7% of myastheni...
- Role of MKP-1 in Osteoclasts and Bone Homeostasis
[作者：Carlson, J; Cui, WG; Zhang, Q; Xu, XQ; Mercan, F; Bennett, AM; Vignery, A,期刊：American Journal of Pathology, 页码：1564-1573 , 文章类型： Article，,卷期：2009年175-4]
- Bone mass is maintained through the complementary activities of osteoblasts and osteoclasts; yet differentiation of either osteoblasts and osteoclasts engages the mitogen-activated protein kinase (WAPK) pathway. The MAPK...
- Overexpression of Wild-Type Murine Tau Results in Progressive Tauopathy and Neurodegeneration
[作者：Adams, SJ; Crook, RJP; DeTure, M; Randle, SJ; Innes, AE; Yu, XZ; Lin, WL; Dugger, BN; McBride, M; Hutton, M; Dickson, DW; McGowan, E,期刊：American Journal of Pathology, 页码：1598-1609 , 文章类型： Article，,卷期：2009年175-4]
- Here, we describe the generation and characterization of a novel tau transgenic mouse model (mTau) that overexpresses wild-type murine tau protein by twofold compared with endogenous levels. Transgenic tau expression was...
- Is Expression or Activation of Src Kinase Associated with Cancer-Specific Survival in ER-, PR- and HER2-Negative Breast Cancer Patients?
[作者：Elsberger, B; Tan, BA; Mitchell, TJ; Brown, SBF; Mallon, EA; Tovey, SM; Cooke, TG; Brunton, VG; Edwards, J,期刊：American Journal of Pathology, 页码：1389-1397 , 文章类型： Article，,卷期：2009年175-4]
- The aim of the current study was to assess the expression levels of c-Src and phosphorylated Src kinase in human breast cancers and to establish if these are linked to oestrogen receptor, progesterone receptor, and human...
- Lipopolysaccharide-Induced Epithelial Monoamine Oxidase Mediates Alveolar Bone Loss in a Rat Chronic Wound Model
[作者：Ekuni, D; Firth, JD; Nayer, T; Tomofuji, T; Sanbe, T; Irie, K; Yamamoto, T; Oka, T; Liu, ZZ; Vielkind, J; Putnins, EE,期刊：American Journal of Pathology, 页码：1398-1409 , 文章类型： Article，,卷期：2009年175-4]
- Reactive oxygen species (ROS) production is an antimicrobial response to pathogenic challenge that may, in the case of persistent infection, have deleterious effects on the tissue of origin. A rat periodontal disease mod...
- Loss-of-Function FERMT1 Mutations in Kindler Syndrome Implicate a Role for Fermitin Family Homolog-1 in Integrin Activation
[作者：Lai-Cheong, JE; Parsons, M; Tanaka, A; Ussar, S; South, AP; Gomathy, S; Mee, JB; Barbaroux, JB; Techanukul, T; Almaani, N; Clements, SE; Hart, IR; McGrath, JA,期刊：American Journal of Pathology, 页码：1431-1441 , 文章类型： Article，,卷期：2009年175-4]
- Kindler syndrome is an autosomal recessive disorder characterized by skin atrophy and blistering. It results from loss-of-function mutations in the FERMT1 gene encoding the focal adhesion protein, fermitin family homolog...
- Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
[作者：Rensen, SS; Slaats, Y; Nijhuis, J; Jans, A; Bieghs, V; Driessen, A; Malle, E; Greve, JW; Buurman, WA,期刊：American Journal of Pathology, 页码：1473-1482 , 文章类型： Article，,卷期：2009年175-4]
- Inflammation and oxidative stress are considered critical factors in the progression of nonalcoholic fatty liver disease. Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; the...
- Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice
[作者：Haridass, D; Yuan, QG; Becker, PD; Cantz, T; Iken, M; Rothe, M; Narain, N; Bock, M; Norder, M; Legrand, N; Wedemeyer, H; Weijer, K; Spits, H; Manns, MP; Cai, J; Deng, HK; Di Santo, JP; Guzman, CA; Ott, M,期刊：American Journal of Pathology, 页码：1483-1492 , 文章类型： Article，,卷期：2009年175-4]
- Fetal liver progenitor cell suspensions (FLPC) and hepatic precursor cells derived from embryonic stem cells (ES-HPC) represent a potential source for liver cell therapy. However, the relative capacity of these cell type...
- Tacrolimus Ameliorates Metabolic Disturbance and Oxidative Stress Caused by Hepatitis C Virus Core Protein Analysis Using Mouse Model and Cultured Cells
[作者：Moriya, K; Miyoshi, H; Tsutsumi, T; Shinzawa, S; Fujie, H; Shintani, Y; Yotsuyanagi, H; Moriishi, K; Matsuura, Y; Suzuki, T; Miyamura, T; Koike, K,期刊：American Journal of Pathology, 页码：1515-1524 , 文章类型： Article，,卷期：2009年175-4]
- Hepatic steatosis and insulin resistance are factors that aggravate the progression of liver disease caused by hepatitis C virus (HCV) infection. In the pathogenesis of liver disease and metabolic disorders in HCV infect...
- Correlation of CXCL12 Expression and FoxP3(+) Cell Infiltration with Human Papillomavirus Infection and Clinicopathological Progression of Cervical Cancer
[作者：Jaafar, F; Righi, E; Lindstrom, V; Linton, C; Nohadani, M; Van Noorden, S; Lloyd, T; Poznansky, J; Stamp, G; Dina, R; Coleman, DV; Poznansky, MC,期刊：American Journal of Pathology, 页码：1525-1535 , 文章类型： Article，,卷期：2009年175-4]
- Human cervical cancer is an immunogenic tumor with a defined pattern of histopathological and clinical progression. Tumor-infiltrating T cells contribute to immune control of this tumor; however, cervical cancer dysregul...
- Myotendinous Junction Defects and Reduced Force Transmission in Mice that Lack alpha 7 Integrin and Utrophin
[作者：Welser, JV; Rooney, JE; Cohen, NC; Gurpur, PB; Singer, CA; Evans, RA; Haines, BA; Burkin, DJ,期刊：American Journal of Pathology, 页码：1545-1554 , 文章类型： Article，,卷期：2009年175-4]
- The alpha 7 beta 1 integrin, dystrophin, and utrophin glycoprotein complexes are the major laminin receptors in skeletal muscle. Loss of dystrophin causes Duchenne muscular dystrophy, a lethal muscle wasting disease. Duc...
- High Levels of Tumor Necrosis Factor-alpha Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing
[作者：Alblowi, J; Kayal, RA; Siqueria, M; McKenzie, E; Krothapalli, N; McLean, J; Conn, J; Nikolajczyk, B; Einhorn, TA; Gerstenfeld, L; Graves, DT,期刊：American Journal of Pathology, 页码：1574-1585 , 文章类型： Article，,卷期：2009年175-4]
- Diabetes interferes with fracture repair; therefore, we investigated mechanisms of impaired fracture heating in a model of multiple low-dose streptozotocin-induced diabetes. Microarray and gene set enrichment analysis re...
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