- Up-Regulation of Bcl-xl by Hepatocyte Growth Factor in Human Mesothelioma Cells Involves ETS Transcription Factors
[作者:Cao, XB; Littlejohn, J; Rodarte, C; Zhang, LD; Martino, B; Rascoe, P; Hamid, K; Jupiter, D; Smythe, WR,期刊:American Journal of Pathology, 页码:2207-2216 , 文章类型: Article,,卷期:2009年175-5]
- Bcl-xl and the hepatocyte growth factor (HGF) receptor c-Met are both highly expressed in mesotheliomas, where they protect cells from apoptosis and can confer resistance to conventional therapeutic agents. In our curren...
- Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells
[作者:Onuma, K; Sato, Y; Ogawara, S; Shirasawa, N; Kobayashi, M; Yoshitake, J; Yoshimura, T; Iigo, M; Fujii, J; Okada, F,期刊:American Journal of Pathology, 页码:2171-2183 , 文章类型: Article,,卷期:2009年175-5]
- Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO2)...
- Sphingosine Kinase-1 Associates with Integrin alpha(V)beta(3) to Mediate Endothelial Cell Survival
[作者:Gamble, JR; Sun, WY; Li, XC; Hahn, CN; Pitson, SM; Vadas, MA; Bonder, CS,期刊:American Journal of Pathology, 页码:2217-2225 , 文章类型: Article,,卷期:2009年175-5]
- Sphingosine kinase (SK)-1 promotes endothelial cell (EC) survival through the cell junction molecule CD31 (platelet endothelial cell adhesion molecule-1). The integrin alpha(v)beta(3) is also essential for EC survival; i...
- The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy
[作者:Hayashi, S; Yamamoto, A; You, F; Yamashita, K; Ikegame, Y; Tawada, M; Yoshimori, T; Shimizu, S; Nakashima, S,期刊:American Journal of Pathology, 页码:2226-2234 , 文章类型: Article,,卷期:2009年175-5]
- Clinical studies have indicated that the stent-eluting drugs sirolimus and paclitaxel impact restenosis; however, it is still elusive how these drugs affect the vascular endothelium at the molecular and cellular levels. ...
- Subcellular Localization of the HER4 Intracellular Domain, 4ICD, Identifies Distinct Prognostic Outcomes for Breast Cancer Patients
[作者:Thor, AD; Edgerton, SM; Jones, FE,期刊:American Journal of Pathology, 页码:1802-1809 , 文章类型: Article,,卷期:2009年175-5]
- Conflicting reports of the prognostic value of HER4 in breast cancer may be explained by distinct activities of the HER4 intracellular domain, 4ICD. Here, immunohistochemical 4ICD staining of archival invasive breast can...
- Genetic Manipulation of Dysferlin Expression in Skeletal Muscle Novel Insights into Muscular Dystrophy
[作者:Millay, DP; Maillet, M; Roche, JA; Sargent, MA; McNally, EM; Bloch, RJ; Molkentin, JD,期刊:American Journal of Pathology, 页码:1817-1823 , 文章类型: Article,,卷期:2009年175-5]
- Mutations in the gene DYSF, which codes for the protein dysferlin, underlie Miyoshi myopathy and limb-girdle muscular dystrophy 2B in humans and produce a slowly progressing skeletal muscle degenerative disease in mice. ...
- Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria
[作者:Area-Gomez, E; de Groof, AJC; Boldogh, I; Bird, TD; Gibson, GE; Koehler, CM; Yu, WH; Duff, KE; Yaffe, MP; Pon, LA; Schon, EA,期刊:American Journal of Pathology, 页码:1810-1816 , 文章类型: Article,,卷期:2009年175-5]
- Presenilin-1 (PSI) and -2 (PS2), which when mutated cause familial Alzheimer disease, have been localized to numerous compartments of the cell, including the endoplasmic reticulum, Golgi, nuclear envelope, endosomes, lys...
- Genoproteomic Mining of Urothelial Cancer Suggests gamma-Glutamyl Hydrolase and Diazepam-Binding Inhibitor as Putative Urinary Markers of Outcome after Chemotherapy
[作者:Pollard, C; Nitz, M; Baras, A; Williams, P; Moskaluk, C; Theodorescu, D,期刊:American Journal of Pathology, 页码:1824-1830 , 文章类型: Article,,卷期:2009年175-5]
- Urinary biomarkers for the detection of bladder cancer have been developed, but no similar markers exist for prediction of clinical outcomes after receiving chemotherapy. Here we evaluate an approach that combines genomi...
- Detection of Genomic Amplification of the Human Telomerase Gene TERC, a Potential Marker for Triage of Women with HPV-Positive, Abnormal Pap Smears
[作者:Andersson, S; Sowjanya, P; Wangsa, D; Hjerpe, A; Johansson, B; Auer, G; Gravitt, PE; Larsson, C; Wallin, KL; Ried, T; Heselmeyer-Haddad, K,期刊:American Journal of Pathology, 页码:1831-1847 , 文章类型: Article,,卷期:2009年175-5]
- The vast majority of invasive cervical carcinomas harbor additional copies of the chromosome arm 3q, resulting in genomic amplification of the human telomerase gene TERC. Here, we evaluated TERC amplification in routinel...
- Transcription Factors Kruppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-gamma Mediate High Glucose-Induced Thioredoxin-Interacting Protein
[作者:Qi, W; Chen, XM; Holian, J; Tan, CYR; Kelly, DJ; Pollock, CA,期刊:American Journal of Pathology, 页码:1858-1867 , 文章类型: Article,,卷期:2009年175-5]
- We demonstrated recently that thioredoxin-interacting protein (Txnip) and the transcription factor Kruppel-like factor 6 (KLF6) were up-regulated in both in vivo and in vitro models of diabetic nephropathy, thus promotin...
- alpha 7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation
[作者:Maouche, K; Polette, M; Jolly, T; Medjber, K; Cloez-Tayarani, I; Changeux, JP; Burlet, H; Terryn, C; Coraux, C; Zahm, JM; Birembaut, P; Tournier, JM,期刊:American Journal of Pathology, 页码:1868-1882 , 文章类型: Article,,卷期:2009年175-5]
- Airway epithelial basal cells are known to be critical for regenerating injured epithelium and maintaining tissue homeostasis. Recent evidence suggests that the alpha 7 nicotinic acetylcholine receptor (nAChR), which is ...
- Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease
[作者:Hakroush, S; Moeller, MJ; Theilig, F; Kaissling, B; Sijmonsma, TP; Jugold, M; Akeson, AL; Traykova-Brauch, M; Hosser, H; Hahnel, B; Grone, HJ; Koesters, R; Kriz, W,期刊:American Journal of Pathology, 页码:1883-1895 , 文章类型: Article,,卷期:2009年175-5]
- The role of vascular endothelial growth factor (VEGF) in renal fibrosis, tubular cyst formation, and glomerular diseases is incompletely understood. We studied a new conditional transgenic mouse system [Pax8-rtTA/(tetO)(...
- Double-Stranded DNA Activates Glomerular Endothelial Cells and Enhances Albumin Permeability via a Toll-Like Receptor-Independent Cytosolic DNA Recognition Pathway
[作者:Hagele, H; Allam, R; Pawar, RD; Reichel, CA; Krombach, F; Anders, HJ,期刊:American Journal of Pathology, 页码:1896-1904 , 文章类型: Article,,卷期:2009年175-5]
- Viral DNA induces potent antiviral immunity by activating dendritic cells; however, the mechanism governing viral DNA-mediated triggering or aggravation of glomerulonephritis is unknown. Glomerular endothelial cells (GEn...
- Age-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation
[作者:Simpson, RML; Meran, S; Thomas, D; Stephens, P; Bowen, T; Steadman, R; Phillips, A,期刊:American Journal of Pathology, 页码:1915-1928 , 文章类型: Article,,卷期:2009年175-5]
- We have previously demonstrated that transforming growth factor-beta 1 (TGF-beta 1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (RA) pericellular coat. The current st...
- Protection against Hepatocyte Mitochondrial Dysfunction Delays Fibrosis Progression in Mice
[作者:Mitchell, C; Robin, MA; Mayeuf, A; Mahrouf-Yorgov, M; Mansouri, A; Hamard, M; Couton, D; Fromenty, B; Gilgenkrantz, H,期刊:American Journal of Pathology, 页码:1929-1937 , 文章类型: Article,,卷期:2009年175-5]
- Accumulating evidence indicates that oxidative stress is involved in the physiopathology of liver fibrogenesis. However, amid the global context of hepatic oxidative stress, the specific role of hepatocyte mitochondrial ...
- Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice
[作者:Zattra, E; Coleman, C; Arad, S; Helms, E; Levine, D; Bord, E; Guillaume, A; El-Hajahmad, M; Zwart, E; van Steeg, H; Gonzalez, S; Kishore, R; Goukassian, DA,期刊:American Journal of Pathology, 页码:1952-1961 , 文章类型: Article,,卷期:2009年175-5]
- UV-irradiated skin and UV-induced tumors overexpress the inducible isoform of cyclooxygenase-2 (Cox-2), and Cox-2 inhibition reduces photocarcinogenesis. To evaluate photoprotective effects of Polypodium leucotomos extra...
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