- Involvement of L-Selectin in Contact Hypersensitivity Responses Augmented by Auditory Stress
[作者:Bae, SJ; Shimizu, K; Yozaki, M; Yamaoka, T; Akiyama, Y; Yoshizaki, A; Muroi, E; Hara, T; Ogawa, F; Sato, S,期刊:American Journal of Pathology, 页码:187-197 , 文章类型: Article,,卷期:2010年176-1]
- Stress affects the pathophysiology of cutaneous immune reactions, including contact hypersensitivity (CH) in individuals sensitized with sensitizing hapten, where local endothelial cell activation plays a critical role. ...
- CD11c(+) Cells Are Required to Prevent Progression from Local Acute Lung Injury to Multiple Organ Failure and Death
[作者:Milaim, JE; Erb-Downward, JR; Chen, GH; Osuchowski, MF; McDonald, R; Chensue, SW; Toews, GB; Huffnagle, GB; Olszewski, MA,期刊:American Journal of Pathology, 页码:218-226 , 文章类型: Article,,卷期:2010年176-1]
- To investigate the role of CD11c(+) cells in endotoxin induced acute lung injury, wild-type or CD11c-diphtheria toxin receptor transgenic mice were treated with intraperitoneal diphtheria toxin (5 ng/g b.wt.) in the pres...
- Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria
[作者:Spaccapelo, R; Janse, CJ; Caterbi, S; Franke-Fayard, B; Bonilla, JA; Syphard, LM; Di Cristina, M; Dottorini, T; Savarino, A; Cassone, A; Bistoni, F; Waters, AP; Dame, JB; Crisanti, A,期刊:American Journal of Pathology, 页码:205-217 , 文章类型: Article,,卷期:2010年176-1]
- Plasmodium parasites lacking plasmepsin 4 (PM4), an aspartic protease that functions in the lysosomal compartment and contributes to hemoglobin digestion, have only a modest decrease in the asexual blood-stage growth rat...
- alpha 2-Antiplasmin Is Associated with the Progression of Fibrosis
[作者:Kanno, Y; Kawashita, E; Minamida, M; Kaneiwa, A; Okada, K; Ueshima, S; Matsuo, O; Matsuno, H,期刊:American Journal of Pathology, 页码:238-245 , 文章类型: Article,,卷期:2010年176-1]
- Systemic sclerosis results in tissue fibrosis due to the activation of fibroblasts and the ensuing overproduction of the extracellular matrix. We previously reported that the absence of alpha 2-antiplasmin (alpha 2AP) at...
- Dendritic Cells Express Hematopoietic Prostaglandin D Synthase and Function as a Source of Prostaglandin D2 in the Skin
[作者:Shimura, C; Satoh, T; Igawa, K; Aritake, K; Urade, Y; Nakamura, M; Yokozeki, H,期刊:American Journal of Pathology, 页码:227-237 , 文章类型: Article,,卷期:2010年176-1]
- Prostaglandin D2 (PGD2), an arachidonic acid metabolite, has been implicated in allergic responses. A major source of PGD2 in the skin is mast cells that express hematopoietic PGD synthase (H-PGDS). In this study, we sho...
- Downstream Targets of Homeobox Gene HLX Show Altered Expression in Human Idiopathic Fetal Growth Restriction
[作者:Rajaraman, G; Murthi, P; Pathirage, N; Brennecke, SP; Kalionis, B,期刊:American Journal of Pathology, 页码:278-287 , 文章类型: Article,,卷期:2010年176-1]
- Fetal growth restriction (FGR), a clinically significant pregnancy disorder, is poorly understood at the molecular level. This study investigates idiopathic FGR associated with placental insufficiency. Previously, we sho...
- Antigen-Specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis
[作者:Seier, AM; Renkl, AC; Schulz, G; Uebele, T; Sindrilaru, A; Iben, S; Liaw, L; Kon, S; Uede, T; Weiss, JM,期刊:American Journal of Pathology, 页码:246-258 , 文章类型: Article,,卷期:2010年176-1]
- Allergic contact dermatitis is a T cell-mediated immune response, which in its relapsing chronic form is of high socioeconomic impact. The phosphoglycoprotein osteopontin (OPN) has chemotactic and Th1 cytokine functions ...
- Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration
[作者:Takahashi, S; Ohshima, T; Hirasawa, M; Pareek, TK; Bugge, TH; Morozov, A; Fujieda, K; Brady, RO; Kulkarni, AB,期刊:American Journal of Pathology, 页码:320-329 , 文章类型: Article,,卷期:2010年176-1]
- Neuronal migration disorders are often identified in patients with epilepsy refractory to medical treatment. The prolonged or repeated seizures are known to cause neuronal death; however, the mechanism underlying seizure...
- MicroRNAs May Mediate the Down-Regulation of Neurokinin-1 Receptor in Chronic Bladder Pain Syndrome
[作者:Freire, VS; Burkhard, FC; Kessler, TM; Kuhn, A; Draeger, A; Monastyrskaya, K,期刊:American Journal of Pathology, 页码:288-303 , 文章类型: Article,,卷期:2010年176-1]
- Bladder pain syndrome (BPS) is a clinical syndrome of pelvic pain and urinary urgency-frequency in the absence of a specific cause. Investigating the expression levels of genes involved in the regulation of epithelial pe...
- The Absence of Interleukin-6 Enhanced Arsenite-Induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aberrant Extracellular Signal-Regulated Kinase Activation
[作者:Kimura, A; Ishida, Y; Wada, T; Hisaoka, T; Morikawa, Y; Sugaya, T; Mukaida, N; Kondo, T,期刊:American Journal of Pathology, 页码:40-50 , 文章类型: Article,,卷期:2010年176-1]
- Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by ...
- Endogenous LXA(4) Circuits Are Determinants of Pathological Angiogenesis in Response to Chronic Injury
[作者:Leedom, AJ; Sullivan, AB; Dong, BY; Lau, D; Gronert, K,期刊:American Journal of Pathology, 页码:74-84 , 文章类型: Article,,卷期:2010年176-1]
- Inflammation and angiogenesis are intimately linked, and their dysregulation leads to pathological angiogenesis in human diseases. 15-lipoxygenase (15-LOX) and lipoxin A(4) receptors (ALX) constitute a LXA(4) circuit tha...
- Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
[作者:Humphreys, BD; Lin, SL; Kobayashi, A; Hudson, TE; Nowlin, BT; Bonventre, JV; Valerius, MT; McMahon, AP; Duffield, JS,期刊:American Journal of Pathology, 页码:85-97 , 文章类型: Article,,卷期:2010年176-1]
- Understanding the origin of myofibroblasts in kidney is of great interest because these cells are responsible for scar formation in fibrotic kidney disease. Recent studies suggest epithelial cells are an important source...
- Dermal Transforming Growth Factor-beta Responsiveness Mediates Wound Contraction and Epithelial Closure
[作者:Martinez-Ferrer, M; Afshar-Sherif, AR; Uwamariya, C; de Crombrugghe, B; Davidson, JM; Bhowmick, NA,期刊:American Journal of Pathology, 页码:98-107 , 文章类型: Article,,卷期:2010年176-1]
- Stromal-epithelial interactions are important during wound healing. Transforming growth factor-beta (TGF-beta) signaling at the wound site has been implicated in re-epithelization, inflammatory infiltration, wound contra...
- Small Cytoskeleton-Associated Molecule, Fibroblast Growth Factor Receptor 1 Oncogene Partner 2/Wound Inducible Transcript-3.0 (FGFR1OP2/wit3.0), Facilitates Fibroblast-Driven Wound Closure
[作者:Lin, A; Hokugo, A; Choi, J; Nishimura, I,期刊:American Journal of Pathology, 页码:108-121 , 文章类型: Article,,卷期:2010年176-1]
- Wounds created in the oral cavity heal rapidly and leave minimal scarring. We have examined a role of a previously isolated cDNA from oral wounds encoding wound inducible transcript-3.0 (wit3-0), also known as fibroblast...
- Enoxaparin Improves the Course of Dextran Sodium Sulfate-Induced Colitis in Syndecan-1-Deficient Mice
[作者:Floer, M; Gotte, M; Wild, MK; Heidemann, J; Gassar, ES; Domschke, W; Kiesel, L; Luegering, A; Kucharzik, T,期刊:American Journal of Pathology, 页码:146-157 , 文章类型: Article,,卷期:2010年176-1]
- Syndecan-1 (Sdc1) plays a major role in wound healing and modulates inflammatory responses. Sdc1 expression is reduced in lesions of patients with ulcerative colitis. The aim of this study was to investigate the role of ...
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