- Parabiotic Heterogenetic Pairing of Abcc6(-/-)/Ragl(-/-) Mice and Their Wild-Type Counterparts Halts Ectopic Mineralization in a Murine Model of Pseudoxanthoma Elasticum
[作者:Jiang, QJ; Oldenburg, R; Otsuru, S; Grand-Pierre, AE; Horwitz, EM; Uitto, J,期刊:American Journal of Pathology, 页码:1855-1862 , 文章类型: Article,,卷期:2010年176-4]
- Pseudoxanthoma elasticum (PXE), a pleiotropic heritable disorder, is characterized by ectopic mineralization of the connective tissues. This disease is caused by mutations in the ABCC6 gene, which is expressed primarily ...
- Therapeutic Potential of Protepsome Inhibition in Duchenne and Becker Muscular Dystrophies
[作者:Gazzerro, E; Assereto, S; Bonetto, A; Sotgia, F; Scarfi, S; Pistorio, A; Bonuccelli, G; Cilli, M; Bruno, C; Zara, F; Lisanti, MP; Minetti, C,期刊:American Journal of Pathology, 页码:1863-1877 , 文章类型: Article,,卷期:2010年176-4]
- Duchenne muscular dystrophy (DMD) and its milder allelic variant, Becker muscular dystrophy (BMD), result from mutations of the dystrophin gene and lead to progressive muscle deterioration. Enhanced activation of proteas...
- Tumor Suppressor Function of Androgen Receptor Coactivator ARA70 alpha in Prostate Cancer
[作者:Ligr, M; Li, YR; Zou, XY; Daniels, G; Melamed, J; Peng, Y; Wang, W; Wang, JH; Ostrer, H; Pagano, M; Wang, ZX; Garabedian, MJ; Lee, P,期刊:American Journal of Pathology, 页码:1891-1900 , 文章类型: Article,,卷期:2010年176-4]
- Androgen receptor (AR), a member of the steroid receptor family, is a transcription factor that has an important role in the regulation of both prostate cell proliferation and growth suppression. AR coactivators may infl...
- Establishment and Genomic Characterization of Mouse Xenografts of Human Primary Prostate Tumors
[作者:Priolo, C; Agostini, M; Vena, N; Ligon, AH; Fiorentino, M; Shin, E; Farsetti, A; Pontecorvi, A; Sicinska, E; Loda, M,期刊:American Journal of Pathology, 页码:1901-1913 , 文章类型: Article,,卷期:2010年176-4]
- Serum prostate-specific antigen screening has led to earlier detection and surgical treatment of prostate cancer, favoring an increasing incidence-to-mortality ratio. However, about one third of tumors that are diagnosed...
- MCP1 Directs Trafficking of Hematopoietic Stem Cell-Derived Fibroblast Precursors in Solid Tumor
[作者:Abangan, RS; Williams, CR; Mehrotra, M; Duncan, JD; LaRue, AC,期刊:American Journal of Pathology, 页码:1914-1926 , 文章类型: Article,,卷期:2010年176-4]
- Our previous studies have demonstrated that hematopoietic stem cells (HSCs) are a novel source of carcinoma-associated fibroblasts. However, the mechanisms regulating recruitment and homing of HSC-derived carcinoma-assoc...
- Ricinus communis Agglutinin I Leads to Rapid Down-Regulation of VEGFR-2 and Endothelial Cell Apoptosis in Tumor Blood Vessels
[作者:You, WK; Kasman, I; Hu-Lowe, DD; McDonald, DM,期刊:American Journal of Pathology, 页码:1927-1940 , 文章类型: Article,,卷期:2010年176-4]
Ricinus communis agglutinin I (RCA I), a galactose-binding lectin from castor beans, binds to endothelial cells at sites of plasma leakage, but little is known about the amount and functional consequences of binding t...
- Regulation of p63 Isoforms by Snail and Slug Transcription Factors in Human Squamous Cell Carcinoma
[作者:Herfs, M; Hubert, P; Suarez-Carmona, M; Reschner, A; Saussez, S; Berx, G; Savagner, P; Boniver, J; Delvenne, P,期刊:American Journal of Pathology, 页码:1941-1949 , 文章类型: Article,,卷期:2010年176-4]
- TP63 is a p53-related gene that contains two alternative promoters which give rise to transcripts that encode proteins with (TAp63) or without (Delta Np63) an amino-transactivating domain. Whereas the expression of p63 i...
- Endogenous Angiogenesis Inhibitor Vasohibin1 Exhibits Broad-Spectrum Antilymphangiogenic Activity and Suppresses Lymph Node Metastasis
[作者:Heishi, T; Hosaka, T; Suzuki, Y; Miyashita, H; Oike, Y; Takahashi, T; Nakamura, T; Arioka, S; Mitsuda, Y; Takakura, T; Hojo, K; Matsumoto, M; Yamauchi, C; Ohta, H; Sonoda, H; Sato, Y,期刊:American Journal of Pathology, 页码:1950-1958 , 文章类型: Article,,卷期:2010年176-4]
- During cancer progression, the angiogenesis that occurs is involved in tumor growth and hematogenous-distant metastasis, whereas lymphangiogenesis is involved in regional lymph node metastasis. Angiogenesis is counterreg...
- Function of EWS-POU5F1 in Sarcomagenesis and Tumor Cell Maintenance
[作者:Fujino, T; Nomura, K; Ishikawa, Y; Makino, H; Umezawa, A; Aburatani, H; Nagasaki, K; Nakamura, T,期刊:American Journal of Pathology, 页码:1973-1982 , 文章类型: Article,,卷期:2010年176-4]
- POU5F1 is a transcription factor essential for the self-renewal activity and pluripotency of embryonic stem cells and germ cells. We have previously reported that POU5F1 is fused to EWSR1 in a case of undifferentiated sa...
- Endothelial Fli1 Deficiency Impairs Vascular Homeostasis A Role in Scleroderma Vasculopathy
[作者:Asano, Y; Stawski, L; Hant, F; Highland, K; Silver, R; Szalai, G; Watson, DK; Trojanowska, M,期刊:American Journal of Pathology, 页码:1983-1998 , 文章类型: Article,,卷期:2010年176-4]
- Systemic sclerosis or scleroderma (SSc) is a complex autoimmune connective tissue disease characterized by obliterative vasculopathy and tissue fibrosis. The molecular mechanisms underlying SSc vasculopathy are largely u...
- Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation
[作者:Fuxe, J; Lashnits, E; O'Brien, S; Baluk, P; Tabruyn, SP; Kuhnert, F; Kuo, C; Thurston, G; McDonald, DM,期刊:American Journal of Pathology, 页码:2009-2018 , 文章类型: Article,,卷期:2010年176-4]
- Vascular endothelial growth factor (VEGF) is a key angiogenic factor in tumors, but less is known about what drives vascular remodeling in inflammation, where plasma leakage and leukocyte influx are prominent features. I...
- Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth
[作者:Krasnoperov, V; Kumar, SR; Ley, E; Li, XQ; Scehnet, J; Liu, R; Zozulya, S; Gill, PS,期刊:American Journal of Pathology, 页码:2029-2038 , 文章类型: Article,,卷期:2010年176-4]
- EphB4 receptor tyrosine kinase and its cognate ligand EphrinB2 regulate induction and maturation of newly forming vessels. Inhibition of their interaction arrests angiogenesis, vessel maturation, and pericyte recruitment...
- Therapeutic Targeting of Classical and Lectin Pathways of Complement Protects from Ischemia-Reperfusion-Induced Renal Damage
[作者:Castellano, G; Melchiorre, R; Loverre, A; Ditonno, P; Montinaro, V; Rossini, M; Divella, C; Battaglia, M; Lucarelli, G; Annunziata, G; Palazzo, S; Selvaggi, FP; Staffieri, F; Crovace, A; Daha, MR; Mannesse, M; van Wetering, S; Schena, FP; Grandaliano, G,期刊:American Journal of Pathology, 页码:1648-1659 , 文章类型: Article,,卷期:2010年176-4]
- Ischemia-reperfusion injury is the major cause of delayed graft function in transplanted kidneys, an early event significantly affecting long-term graft function and survival. Several studies in rodents suggest that the ...
- Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid-Induced cPLA(2)/COX-2-Dependent Airway Inflammatory Responses
[作者:Lee, IT; Lee, CW; Tung, WH; Wang, SW; Lin, CC; Shu, JC; Yang, CM,期刊:American Journal of Pathology, 页码:1671-1684 , 文章类型: Article,,卷期:2010年176-4]
- Lipoteichoic acid (LTA) plays a role in the pathogenesis of severe inflammatory responses induced by Gram-positive bacterial infection. Cytosolic phospholipase A(2) (cPLA(2)), cyclooxygenase-2 (COX-2), prostaglandin E-2 ...
- Primary Cell Cultures from Human Renal Cortex and Renal-Cell Carcinoma Evidence a Differential Expression of Two Spliced Isoforms of Annexin A3
[作者:Bianchi, C; Bombelli, S; Raimondo, F; Torsello, B; Angeloni, V; Ferrero, S; Di Stefano, V; Chinello, C; Cifola, I; Invernizzi, L; Brambilla, P; Magni, F; Pitto, M; Zanetti, G; Mocarelli, P; Perego, RA,期刊:American Journal of Pathology, 页码:1660-1670 , 文章类型: Article,,卷期:2010年176-4]
- Primary cell cultures from renal cell carcinoma (RCC) and normal renal cortex tissue of 60 patients have been established, with high efficiency (more than 70%) and reproducibility, and extensively characterized. These cu...
- Functions of Type II Pneumocyte-Derived Vascular Endothelial Growth Factor in Alveolar Structure, Acute Inflammation, and Vascular Permeability
[作者:Mura, M; Binnie, M; Han, B; Li, CJ; Andrade, CF; Shiozaki, A; Zhang, Y; Ferrara, N; Hwang, D; Waddell, TK; Keshavjee, S; Liu, MY,期刊:American Journal of Pathology, 页码:1725-1734 , 文章类型: Article,,卷期:2010年176-4]
- Vascular endothelial growth factor-A (VEGF) is a potent regulator of vascular permeability, inflammatory response, and cell survival in the lung. To explore the functions of VEGF produced locally in type II pneumocytes, ...
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