- Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
[作者：Anisimov, VN; Zabezhinski, MA; Popovich, IG; Piskunova, TS; Semenchenko, AV; Tyndyk, ML; Yurova, MN; Antoch, MP; Blagosklonny, MV,期刊：American Journal of Pathology, 页码：2092-2097 , 文章类型： Article，,卷期：2010年176-5]
- Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing mammalian target of rapamycin (mTOR) pathway is involved in cellula...
- The Novel Association of the Chemokine CCL22 with Abdominal Aortic Aneurysm
[作者：Golledge, J; Clancy, P; Moran, C; Biros, E; Rush, C; Walker, P; Norman, P,期刊：American Journal of Pathology, 页码：2098-2106 , 文章类型： Article，,卷期：2010年176-5]
- The aim of this study was to examine aortic biopsies with a cytokine array to identify new cytokines associated with abdominal aortic aneurysm (AAA). We assessed the relative expression of 79 cytokines using antibody-bas...
- In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis
[作者：Neumeister, V; Agarwal, S; Bordeaux, J; Camp, RL; Rimm, DL,期刊：American Journal of Pathology, 页码：2131-2138 , 文章类型： Article，,卷期：2010年176-5]
- A subset of cells, tentatively called cancer stem cells (CSCs), in breast cancer have been associated with tumor initiation, drug resistance, and tumor persistence or aggressiveness. They are characterized by CD44 positi...
- The Tetraspanin CD37 Protects Against Glomerular IgA Deposition and Renal Pathology
[作者：Rops, AL; Figdor, CG; van der Schaaf, A; Tamboer, WP; Bakker, MA; Berden, JH; Dijkman, HBPM; Steenbergen, EJ; van der Vlag, J; van Spriel, AB,期刊：American Journal of Pathology, 页码：2188-2197 , 文章类型： Article，,卷期：2010年176-5]
- The tetraspanin protein CD37 is a leukocyte-specific transmembrane protein that is highly expressed on B cells. CD37-deficient (CD37(-/-)) mice exhibit a 15-fold increased level of immunoglobulin A (IgA) in serum and ele...
- Induction of Diabetes in Aged C57B6 Mice Results in Severe Nephropathy An Association with Oxidative Stress, Endoplasmic Reticulum Stress, and Inflammation
[作者：Wu, J; Zhang, RH; Torreggiani, M; Ting, A; Xiong, HB; Striker, GE; Vlassara, H; Zheng, F,期刊：American Journal of Pathology, 页码：2163-2176 , 文章类型： Article，,卷期：2010年176-5]
- Kidney aging is a slowly progressive process that is postulated to be accelerated by intervening diseases, such as diabetes, due in part to the addition of excessive stress and inflammation from the intervening disease t...
- Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-alpha through Bone Morphogenic Protein-2
[作者：Yan, CL; Grimm, WA; Garner, WL; Qin, L; Travis, T; Tan, NM; Han, YP,期刊：American Journal of Pathology, 页码：2247-2258 , 文章类型： Article，,卷期：2010年176-5]
- Epithelial-mesenchymal transition (EMT), characterized by loss of epithelial adhesion and gain of mesenchymal features, is an important mechanism to empower epithelial cells into the motility that occurs during embryonic...
- VHL Deletion Impairs Mammary Alveologenesis but Is Not Sufficient for Mammary Tumorigenesis
[作者：Seagroves, TN; Peacock, DL; Liao, D; Schwab, LP; Krueger, R; Handorf, CR; Haase, VH; Johnson, RS,期刊：American Journal of Pathology, 页码：2269-2282 , 文章类型： Article，,卷期：2010年176-5]
- Overexpression of hypoxia inducible factor-1 (HIF-1)alpha, which is common in most solid tumors, correlates with poor prognosis and high metastatic risk in breast cancer patients. Because HIF-1 alpha protein stability is...
- Loss of Nkx3.1 Expression in Bacterial Prostatitis A Potential Link Between Inflammation and Neoplasia
[作者：Khalili, M; Mutton, LN; Gurel, B; Hicks, JL; De Marzo, AM; Bieberich, CJ,期刊：American Journal of Pathology, 页码：2259-2268 , 文章类型： Article，,卷期：2010年176-5]
- NKX3.1 is a homeodomain protein that functions as a dosage sensitive prostate-specific transcription factor. Diminished NKX3.1 expression is associated with prostate epithelial cell proliferation in vitro and with increa...
- The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss
[作者：He, LN; Hou, XG; Kanel, G; Zeng, N; Galicia, V; Wang, Y; Yang, JA; Wu, H; Birnbaum, MJ; Stiles, BL,期刊：American Journal of Pathology, 页码：2302-2308 , 文章类型： Article，,卷期：2010年176-5]
- Insulin signaling in the liver leads to accumulation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Deletion of the phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) reduces PIP3 levels ...
- The LTB4-BLT1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury
[作者：Saiwai, H; Ohkawa, Y; Yamada, H; Kumamaru, H; Harada, A; Okano, H; Yokomizo, T; Iwamoto, Y; Okada, S,期刊：American Journal of Pathology, 页码：2352-2366 , 文章类型： Article，,卷期：2010年176-5]
- Traumatic injury in the central nervous system induces inflammation; however, the role of this inflammation is controversial. Precise analysis of the inflammatory cells is important to gain a better understanding of the ...
- Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation
[作者：Mirza, MK; Yuan, J; Gao, XP; Garrean, S; Brovkovych, V; Malik, AB; Tiruppathi, C; Zhao, YY,期刊：American Journal of Pathology, 页码：2344-2351 , 文章类型： Article，,卷期：2010年176-5]
- Caveolin-1 (Cav1), the scaffolding protein of caveolae, has been shown to play an important role in host defense and inflammation. However, the underlying molecular basis for these actions remains elusive. Here, using do...
- Dendritic Cells Produce CXCL13 and Participate in the Development of Murine Small Intestine Lymphoid Tissues
[作者：McDonald, KG; McDonough, JS; Dieckgraefe, BK; Newberry, RD,期刊：American Journal of Pathology, 页码：2367-2377 , 文章类型： Article，,卷期：2010年176-5]
- In the adult intestine, luminal microbiota induce cryptopatches to transform into isolated lymphoid follicles (ILFs), which subsequently act as sites for the generation of IgA responses. The events leading to this conver...
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