- Role of Cripto-1 in Stem Cell Maintenance and Malignant Progression
[作者：Bianco, C; Rangel, MC; Castro, NP; Nagaoka, T; Rollman, K; Gonzales, M; Salomon, DS,期刊：American Journal of Pathology, 页码：532-540 , 文章类型： Review，,卷期：2010年177-2]
- Cripto-1 is critical for early embryonic development and, together with its ligand Nodal, has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Like other embryonic gen...
- Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis in Vitro and in Vivo Advantages Over Bone Marrow-Derived Mesenchymal Stem Cells
[作者：Nakao, N; Nakayama, T; Yahata, T; Muguruma, Y; Saito, S; Miyata, Y; Yamamoto, K; Naoe, T,期刊：American Journal of Pathology, 页码：547-554 , 文章类型： Article，,卷期：2010年177-2]
- Mesenchymal stem cells (MSCs) have emerged as a new therapeutic modality for reconstituting the hematopoietic microenvironment by improving engraftment in stem cell transplantation. However, the availability of conventio...
- The DNA Damage-Binding Protein XPC Is a Frequent Target for Inactivation in Squamous Cell Carcinomas
[作者：de Feraudy, S; Ridd, K; Richards, LM; Kwok, PY; Revet, I; Oh, D; Feeney, L; Cleaver, JE,期刊：American Journal of Pathology, 页码：555-562 , 文章类型： Article，,卷期：2010年177-2]
- XPC, the main damage-recognition protein responsible for nucleotide excision repair of UVB damage to DNA, is lost or mutated in xeroderma pigmentosum group C (XP-C), a rare inherited disease characterized by high inciden...
- Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma
[作者：Bruneau, J; Canioni, D; Renand, A; Marafioti, T; Paterson, JC; Martin-Garcia, N; Gaulard, P; Delfau, MH; Hermine, O; Macintyre, E; Brousse, N; Asnafi, V,期刊：American Journal of Pathology, 页码：570-574 , 文章类型： Article，,卷期：2010年177-2]
- Angioimmunoblastic T-cell lymphoma (AITL) is the most frequent nodal T-cell lymphoma and is characterized by a polymorphic lymph node infiltrate, various dysimmune disorders, and a poor prognosis. Regulatory T-cells (Tre...
- Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder
[作者：Cataldo, AM; McPhie, DL; Lange, NT; Punzell, S; Elmiligy, S; Ye, NZ; Froimowitz, MP; Hassinger, LC; Menesale, EB; Sargent, LW; Logan, DJ; Carpenter, AE; Cohen, BM,期刊：American Journal of Pathology, 页码：575-585 , 文章类型： Article，,卷期：2010年177-2]
- Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased mitochondrial activity as a factor in the manifestation of Bipolar Disorder (BD). Because abnormal mitochondrial morphology is often l...
- Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice
[作者：Buttini, M; Masliah, E; Yu, GQ; Palop, JJ; Chang, SJ; Bernardo, A; Lin, C; Wyss-Coray, T; Huang, YD; Mucke, L,期刊：American Journal of Pathology, 页码：563-569 , 文章类型： Article，,卷期：2010年177-2]
- The lipid transport protein apolipoprotein E (apoE) is abundantly expressed in the brain. Its main isoforms in humans are apoE2, apoE3, and apoE4. ApoE4 is the major known genetic risk factor for Alzheimer's disease and ...
- Tubular Overexpression of Transforming Growth Factor-beta 1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells
[作者：Koesters, R; Kaissling, B; LeHir, M; Picard, N; Theilig, F; Gebhardt, R; Glick, AB; Hahnel, B; Hosser, H; Grone, HJ; Kriz, W,期刊：American Journal of Pathology, 页码：632-643 , 文章类型： Article，,卷期：2010年177-2]
- We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-beta 1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nep...
- The Divergent Roles of Secreted Frizzled Related Protein-1 (SFRP1) in Lung Morphogenesis and Emphysema
[作者：Foronjy, R; Imai, K; Shiomi, T; Mercer, B; Sklepkiewicz, P; Thankachen, J; Bodine, P; D'Armiento, J,期刊：American Journal of Pathology, 页码：598-607 , 文章类型： Article，,卷期：2010年177-2]
- Developmentally expressed genes are believed to play a central role in tissue repair after injury; however, in lung disease their role has not been established. This study demonstrates that SFRP1, an inhibitor of Wnt sig...
- CD137 Is Required for M Cell Functional Maturation but Not Lineage Commitment
[作者：Hsieh, EH; Fernandez, X; Wang, J; Hamer, M; Calvillo, S; Croft, M; Kwon, BS; Lo, DD,期刊：American Journal of Pathology, 页码：666-676 , 文章类型： Article，,卷期：2010年177-2]
- Mucosal immune surveillance depends on M cells that reside in the epithelium overlying Peyer's patch and nasopharyngeal associated lymphoid tissue to transport particles to underlying lymphocytes. M cell development is a...
- Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors Model for Nonalcoholic Steatohepatitis in Mice
[作者：Wang, KY; Tanimoto, A; Yamada, S; Guo, X; Ding, Y; Watanabe, T; Watanabe, T; Kohno, K; Hirano, KI; Tsukada, H; Sasaguri, Y,期刊：American Journal of Pathology, 页码：713-723 , 文章类型： Article，,卷期：2010年177-2]
- Histamine has been proposed to be an important regulator of energy intake and expenditure. The aim of this study was to evaluate histamine regulation of glucose and lipid metabolism and development of nonalcoholic steato...
- Suppression of SLC11A2 Expression Is Essential to Maintain Duodenal Integrity During Dietary Iron Overload
[作者：Shirase, T; Mori, K; Okazaki, Y; Itoh, K; Yamamoto, M; Tabuchi, M; Kishi, F; Jiang, L; Akatsuka, S; Nakao, K; Toyokuni, S,期刊：American Journal of Pathology, 页码：677-685 , 文章类型： Article，,卷期：2010年177-2]
- Iron is essential for the survival of mammals, but iron overload causes fibrosis and carcinogenesis. Reduced iron absorption and regulated release into circulation in duodenal mucosa constitute two major mechanisms of pr...
- Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin
[作者：Muehlbauer, SM; Lima, H; Goldman, DL; Jacobson, LS; Rivera, J; Goldberg, MF; Palladino, MA; Casadevall, A; Brojatsch, J,期刊：American Journal of Pathology, 页码：735-743 , 文章类型： Article，,卷期：2010年177-2]
- NOD-like receptors (NLRs) and caspase-1 are critical components of innate immunity, yet their over-activation has been linked to a long list of microbial and inflammatory diseases, including anthrax. The Bacillus anthrac...
- Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos
[作者：Yao, CJ; Purwanti, N; Karabasil, MR; Azlina, A; Javkhlan, P; Hasegawa, T; Akamatsu, T; Hosoi, T; Ozawa, K; Hosoi, K,期刊：American Journal of Pathology, 页码：724-734 , 文章类型： Article，,卷期：2010年177-2]
- The mRNA and protein levels of aquaporin (AQP)5 in the parotid gland were found to be potentially decreased by lipopolysaccharide (LPS) in vivo in C3H/HeN mice, but only weakly in C3H/HeJ, a TLR4 mutant mouse strain. In ...
- TLR9 Signaling Is Required for Generation of the Adaptive Immune Protection in Cryptococcus neoformans-Infected Lungs
[作者：Zhang, YM; Wang, FY; Bhan, U; Huffnagle, GB; Toews, GB; Standiford, TJ; Olszewski, MA,期刊：American Journal of Pathology, 页码：754-765 , 文章类型： Article，,卷期：2010年177-2]
- To determine whether TLR9 signaling contributes to the development of the adaptive immune response to cryptococcal infection, wild-type (TLR9+/+) and TLR9 knockout (TLR9-/-) BALB/c mice were infected intratracheally with...
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