- GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1
[作者:Huang, Z; Dore, LC; Li, Z; Orkin, SH; Feng, G; Lin, S; Crispino, JD,期刊:Molecular and Cellular Biology, 页码:5168-5180 , 文章类型: Article,,卷期:2009年29-18]
- GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis. Dysregulation of GATA-2 is a hallmark of acute megakaryoblastic leukemia in children with Down syndrome, a malignancy that is ...
- HOXA9 Modulates Its Oncogenic Partner Meis1 To Influence Normal Hematopoiesis
[作者:Hu, YL; Fong, S; Ferrell, C; Largman, C; Shen, WF,期刊:Molecular and Cellular Biology, 页码:5181-5192 , 文章类型: Article,,卷期:2009年29-18]
- While investigating the mechanism of action of the HOXA9 protein, we serendipitously identified Meis1 as a HOXA9 regulatory target. Since HOXA9 and MEIS1 play key developmental roles, are cooperating DNA binding proteins...
- Time-Dependent Activation of Phox2a by the Cyclic AMP Pathway Modulates Onset and Duration of p27(Kip1) Transcription
[作者:Shin, MH; Mavila, N; Wang, WH; Alvarez, SV; Hall, MC; Andrisani, OM,期刊:Molecular and Cellular Biology, 页码:4878-4890 , 文章类型: Article,,卷期:2009年29-18]
- In noradrenergic progenitors, Phox2a mediates cell cycle exit and neuronal differentiation by inducing p27(Kip1) transcription in response to activation of the cyclic AMP (cAMP) pathway. The mechanism of cAMP-mediated ac...
- FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases
[作者:Storz, P; Doppler, H; Copland, JA; Simpson, KJ; Toker, A,期刊:Molecular and Cellular Biology, 页码:4906-4917 , 文章类型: Article,,卷期:2009年29-18]
- The role of the Forkhead transcription factor FOXO3a in processes that promote tumor metastasis is poorly defined. Here, we show that depletion of FOXO3a from cancer cells leads to decreased tumor size specifically due t...
- Coupling Phosphate Homeostasis to Cell Cycle-Specific Transcription: Mitotic Activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead Proteins
[作者:Pondugula, S; Neef, DW; Voth, WP; Darst, RP; Dhasarathy, A; Reynolds, MM; Takahata, S; Stillman, DJ; Kladde, MP,期刊:Molecular and Cellular Biology, 页码:4891-4905 , 文章类型: Article,,卷期:2009年29-18]
- Cells devote considerable resources to nutrient homeostasis, involving nutrient surveillance, acquisition, and storage at physiologically relevant concentrations. Many Saccharomyces cerevisiae transcripts coding for prot...
- Arginine Methylation Regulates Telomere Length and Stability
[作者:Mitchell, TRH; Glenfield, K; Jeyanthan, K; Zhu, XD,期刊:Molecular and Cellular Biology, 页码:4918-4934 , 文章类型: Article,,卷期:2009年29-18]
- TRF2, a component of the shelterin complex, functions to protect telomeres. TRF2 contains an N-terminal basic domain rich in glycines and arginines, similar to the GAR motif that is methylated by protein arginine methylt...
- ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium In Vivo
[作者:Muraoka-Cook, RS; Sandahl, MA; Strunk, KE; Miraglia, LC; Husted, C; Hunter, DM; Elenius, K; Chodosh, LA; Earp, HS,期刊:Molecular and Cellular Biology, 页码:4935-4948 , 文章类型: Article,,卷期:2009年29-18]
- Data concerning the prognostic value of ErbB4 in breast cancer and effects on cell growth have varied in published reports, perhaps due to the unknown signaling consequences of expression of the intracellular proteolytic...
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