- Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival
[作者:Fu, D; Brophy, JAN; Chan, CTY; Atmore, KA; Begley, U; Paules, RS; Dedon, PC; Begley, TJ; Samson, LD,期刊:Molecular and Cellular Biology, 页码:2449-2459 , 文章类型: Article,,卷期:2010年30-10]
- tRNA nucleosides are extensively modified to ensure their proper function in translation. However, many of the enzymes responsible for tRNA modifications in mammals await identification. Here, we show that human AlkB hom...
- Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
[作者:Shi, HX; Yang, K; Liu, X; Liu, XY; Wei, B; Shan, YF; Zhu, LH; Wang, C,期刊:Molecular and Cellular Biology, 页码:2424-2436 , 文章类型: Article,,卷期:2010年30-10]
- Virus infection induces host antiviral responses, including induction of type I interferons. Transcription factor interferon regulatory factor 3 (IRF3) plays a pivotal role and is tightly regulated in this process. Here,...
- Expression of a Testis-Specific Form of Gal3st1 (CST), a Gene Essential for Spermatogenesis, Is Regulated by the CTCF Paralogous Gene BORIS
[作者:Suzuki, T; Kosaka-Suzuki, N; Pack, S; Shin, DM; Yoon, J; Abdullaev, Z; Pugacheva, E; Morse, HC; Loukinov, D; Lobanenkov, V,期刊:Molecular and Cellular Biology, 页码:2473-2484 , 文章类型: Article,,卷期:2010年30-10]
- Previously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. To develop an underst...
- RecQL5 Promotes Genome Stabilization through Two Parallel Mechanisms-Interacting with RNA Polymerase II and Acting as a Helicase
[作者:Islam, MN; Fox, D; Guo, R; Enomoto, T; Wang, WD,期刊:Molecular and Cellular Biology, 页码:2460-2472 , 文章类型: Article,,卷期:2010年30-10]
- The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. To elucidate its mechanism of action, we purified a RecQL5-associated complex and identified its major component as RNA polymera...
- Separable Functions of the Fission Yeast Spt5 Carboxyl-Terminal Domain (CTD) in Capping Enzyme Binding and Transcription Elongation Overlap with Those of the RNA Polymerase II CTD
[作者:Schneider, S; Pei, Y; Shuman, S; Schwer, B,期刊:Molecular and Cellular Biology, 页码:2353-2364 , 文章类型: Article,,卷期:2010年30-10]
- An interaction network connecting mRNA capping enzymes, the RNA polymerase II (Pol II) carboxylterminal domain (CTD), elongation factor Spt5, and the Cdk7 and Cdk9 protein kinases is thought to comprise a transcription e...
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