We report structural and mechanistic studies on the organocatalytic asymmetric transfer hydrogenation of ketimines with trichlorosilane. Amines were obtained in good yields and moderate enantioselectivities. Both experim...
Highly enantioselective and diastereoselective Michael addition of ketones to nitroolefins catalyzed by prolinol sulfinyl ester was achieved in excellent yields Under solvent-free conditions at room temperature.
The asymmetric oxyfunctionalization of alkenes is a fundamental process in synthetic organic chemistry. In this contribution, we review our findings on the enantioselective organocatalyzed oxidation of electron-poor alke...
Binaphthyl-based amino acids (S)-1 and an aminosulfonamide (S)-2 were applied for direct asymmetric aminoxylation with nitrosobenzene. In the presence of either (S)-1 or (S)-2, the aminoxylation of aldehydes proceeded sm...
A new organocatalytic enantioselective conjugate addition reaction of nitrogen-centered heterocycles with alpha,beta-unsaturated ketones has been developed. Promoted by a chiral cinchona alkaloid derived primary amine, t...
Sulfonyl hydrazine is a new functionality for the Lewis base organocatalysis. N-alpha-substituted camphorsulfonyl hydrazines (CaSH) are effective organocatalysts for the asymmetric aza-Michael addition to alpha,beta-unsa...
Alcohols and aldehydes are oxidised to the corresponding methyl esters by reaction with methanol in the presence of crotononitrile as a hydrogen acceptor using a catalyst combination of Ru(PPh3)(3)(CO)H-2 with xantphos.
This review highlights transition-metal-catalyzed cross-coupling reactions in which one of the halogen atoms (or pseudohalogen groups) of di- or polyhalogenated compounds is converted site-selectively into another group....