A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzy1-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)2-(trifluoromethyl )benzonitrile (1), for the topical control of sebum production is reported. This compound, which ...
Cyclic peptide antagonist c[YYDEGLEE1-NH2, which disrupts the interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGERs), represents a promising tool in the fight against cancer and age-rela...
Influenza is an infectious disease caused by the influenza virus, and each year many people suffer from this disease. Hemagglutinin (HA) in the membrane of type A influenza viruses recognizes sialylglyco-conjugate recept...
Engagement of toll-like receptors serve to link innate immune responses with adaptive immunity and can be exploited as powerful vaccine adjuvants for eliciting both primary and anamnestic immune responses. TLR7 agonists ...
The thiopyranopyridine moiety was synthesized as a new heterocyclic base to be inserted at the C-7 position of selected quinolone nuclei followed by a determination of antibacterial activity against strains of Staphyloco...
Thiazolones with an exo-norbornylamine at the 2-position and an isopropyl group on the 5-position are potent 11 beta-HSD1 inhibitors. However, the C-5 center was prone to epimerization in vitro and in vivo, forming a les...