- MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis
[作者:Mann, J; Chu, DCK; Maxwell, A; Oakley, F; Zhu, NL; Tsukamoto, H; Mann, DA,期刊:Gastroenterology, 页码:705-U374 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Myofibroblast transdifferentiation generates hepatic myofibroblasts, which promote liver fibrogenesis. The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a negative regulator of this ...
- Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B
[作者:Fisicaro, P; Valdatta, C; Massari, M; Loggi, E; Biasini, E; Sacchelli, L; Cavallo, MC; Silini, EM; Andreone, P; Missale, G; Ferrari, C,期刊:Gastroenterology, 页码:682-U348 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: The antiviral function of peripheral hepatitis B virus (HBV)-specific T cells can be increased in patients with chronic hepatitis B by blocking the interaction of programmed death (PD)-1 with its ligan...
- Asymptomatic Pancreatic Cystic Neoplasms: Maximizing Survival and Quality of Life Using Markov-Based Clinical Nomograms
[作者:Weinberg, BM; Spiegel, BMR; Tomlinson, JS; Farrell, JJ,期刊:Gastroenterology, 页码:531-540 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: The natural history and management of pancreatic cysts, especially for branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), remain uncertain. We developed evidence-based nomograms to assist...
- In Vivo Molecular Imaging of Colorectal Cancer With Confocal Endomicroscopy by Targeting Epidermal Growth Factor Receptor
[作者:Goetz, M; Ziebart, A; Foersch, S; Vieth, M; Waldner, MJ; Delaney, P; Galle, PR; Neurath, MF; Kiesslich, R,期刊:Gastroenterology, 页码:435-446 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Epidermal growth factor receptor (EGFR) is a therapeutic target for colorectal cancer (CRC). However, technical challenges have limited in vivo imaging of EGFR in CRCs. Confocal laser endomicroscopy (C...
- Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice
[作者:Wartmann, T; Mayerle, J; Kahne, T; Sahin-Toth, M; Ruthenburger, M; Matthias, R; Kruse, A; Reinheckel, T; Peters, C; Weiss, FU; Sendler, M; Lippert, H; Schulz, HU; Aghdassi, A; Dummer, A; Teller, S; Halangk, W; Lerch, MM,期刊:Gastroenterology, 页码:726-737 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB...
- Heme Oxygenase-1 Protects Against Steatohepatitis in Both Cultured Hepatocytes and Mice
[作者:Yu, J; Chu, ESH; Wang, RZ; Wang, SY; Wu, CW; Wong, VWS; Chan, HLY; Farrell, GC; Sung, JJY,期刊:Gastroenterology, 页码:694-U360 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. We investigated the role of HO-1 in nutritional steatohepatitis in vitro and in ...
- Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKK beta Independent of Hydroxylase Activity
[作者:Xue, J; Li, XB; Jiao, S; Wei, Y; Wu, GH; Fang, J,期刊:Gastroenterology, 页码:606-615 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Prolyl hydroxylase (PHD) hydroxylates hypoxia inducible factor (HIF) alpha, leading to HIF alpha degradation. The PHD family comprises PHD1, PHD2, and PHD3. The enzymatic activity of PHDs is O-2-depend...
- Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease
[作者:Baert, F; Moortgat, L; Van Assche, G; Caenepeel, P; Vergauwe, P; De Vos, M; Stokkers, P; Hommes, D; Rutgeerts, P; Vermeire, S; D'Haens, G,期刊:Gastroenterology, 页码:463-468 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Few prospective data are available to support the clinical relevance of mucosal healing in patients with Crohn's disease. This study examined whether complete healing, determined by endoscopy, predicts...
- Protease-Activated Receptor-1 Down-regulates the Murine Inflammatory and Humoral Response to Helicobacter pylori
[作者:Wee, JLK; Chionh, YT; Ng, GZ; Harbour, SN; Allison, C; Pagel, CN; Mackie, EJ; Mitchell, HM; Ferrero, RL; Sutton, P,期刊:Gastroenterology, 页码:573-582 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Helicobacter pylori infection results in a diversity of pathologies, from asymptomatic gastritis to adenocarcinoma. The reason for these diverse outcomes is multifactorial and includes host factors tha...
- The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors
[作者:Modica, S; Gofflot, F; Murzilli, S; D'Orazio, A; Salvatore, L; Pellegrini, F; Nicolucci, A; Tognoni, G; Copetti, M; Valanzano, R; Veschi, S; Mariani-Costantini, R; Palasciano, G; Schoonjans, K; Auwerx, J; Moschetta, A,期刊:Gastroenterology, 页码:636-U295 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: The WNT-adenomatous polyposis coli system controls cell fate in the intestinal epithelium, where compartment-specific genes tightly regulate proliferation, migration, and differentiation. Nuclear recep...
- Screening and Early Treatment of Migrants for Chronic Hepatitis B Virus Infection Is Cost-Effective
[作者:Veldhuijzen, IK; Toy, M; Hahne, SJM; de Wit, GA; Schalm, SW; de Man, RA; Richardus, JH,期刊:Gastroenterology, 页码:522-530 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Persons with chronic hepatitis B virus (HBV) infection are at risk of developing cirrhosis and hepatocellular carcinoma. Early detection of chronic HBV infection through screening and treatment of elig...
- Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection
[作者:Morishima, C; Shuhart, MC; Wang, CC; Paschal, DM; Apodaca, MC; Liu, YZ; Sloan, DD; Graf, TN; Oberlies, NH; Lee, DYW; Jerome, KR; Polyak, SJ,期刊:Gastroenterology, 页码:671-U332 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Silymarin, an extract from the seeds of the milk thistle plant Silybum marianum, has been used for centuries for the treatment of chronic liver diseases. Despite common use by patients with hepatitis C...
- Reg IV Regulates Normal Intestinal and Colorectal Cancer Cell Susceptibility to Radiation-Induced Apoptosis
[作者:Bishnupuri, KS; Luo, QZ; Sainathan, SK; Kikuchi, K; Sureban, SM; Sabarinathan, M; Gross, JH; Aden, K; May, R; Houchen, CW; Anant, S; Dieckgraefe, BK,期刊:Gastroenterology, 页码:616-U261 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Regenerating (Reg) gene IV is predominantly expressed in gastrointestinal cells and highly up-regulated in many gastrointestinal malignancies, including colorectal cancer (CRC). Human CRC cells express...
- Peginterferon Alfa-2a/Ribavirin for 48 or 72 Weeks in Hepatitis C Genotypes 1 and 4 Patients With Slow Virologic Response
[作者:Ferenci, P; Laferl, H; Scherzer, TM; Maieron, A; Hofer, H; Stauber, R; Gschwantler, M; Brunner, H; Wenisch, C; Bischof, M; Strasser, M; Datz, C; Vogel, W; Loschenberger, K; Steindl-Munda, P,期刊:Gastroenterology, 页码:503-U126 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: This randomized multicenter trial evaluated individualization of treatment duration with peginterferon alfa-2a 180 mu g/wk plus ribavirin 1000/1200 mg/day in patients with chronic hepatitis C genotype ...
- Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands
[作者:Capelle, LG; Van Grieken, NCT; Lingsma, HF; Steyerberg, EW; Klokman, WJ; Bruno, MJ; Vasen, HFA; Kuipers, EJ,期刊:Gastroenterology, 页码:487-492 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Although gastric cancer forms part of the Lynch syndrome tumor spectrum, the risk of developing gastric cancer in Lynch syndrome families is unknown, resulting in a lack of clear guidelines for surveil...
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