- FACS-Assisted Microarray Profiling Implicates Novel Genes and Pathways in Zebrafish Gastrointestinal Tract Development
[作者：Stuckenholz, C; Lu, LL; Thakur, P; Kaminski, N; Bahary, N,期刊：Gastroenterology, 页码：1321-1332 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: The zebrafish Danio rerio is an excellent model system for mammalian gastrointestinal development. To identify differentially regulated genes important in gastrointestinal organogenesis, we profiled th...
- Intraepithelial Effector (CD3(+))/Regulatory (FoxP3(+)) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma
[作者：Sinicrope, FA; Rego, RL; Ansell, SM; Knutson, KL; Foster, NR; Sargent, DJ,期刊：Gastroenterology, 页码：1270-1279 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Regulatory T cells (Tregs) express the forkhead box transcription factor (FoxP3) and suppress the antitumor immune response. We investigated whether the intratumoral densities of FoxP3(+) and effector ...
- Colectomy Rate Comparison After Treatment of Ulcerative Colitis With Placebo or Infliximab
[作者：Sandborn, WJ; Rutgeerts, P; Feagan, BG; Reinisch, W; Olson, A; Johanns, J; Lu, JD; Horgan, K; Rachmilewitz, D; Hanauer, SB; Lichtenstein, GR; de Villiers, WJS; Present, D; Sands, BE; Colombel, JF,期刊：Gastroenterology, 页码：1250-1260 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: The efficacy of infliximab for treating patients with ulcerative colitis has been established. METHODS: The Active Ulcerative Colitis Trial (ACT)-1 and ACT-2 randomized, double-blind, placebo-controlle...
- FoxO4 Inhibits NF-kappa 3 and Protects Mice Against Colonic Injury and Inflammation
[作者：Zhou, W; Cao, Q; Peng, Y; Zhang, QJ; Castrillon, DH; Depinho, RA; Liu, ZP,期刊：Gastroenterology, 页码：1403-1414 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: FoxO4 is a member of the forkhead box transcription factor O (FoxO) subfamily. FoxO, proteins are involved in diverse biological processes. In this study, we examine the role of FoxO4 in intestinal muc...
- Cyclooxygenase-2 Inhibitors Down-regulate Osteopontin and Nr4a2-New Therapeutic Targets for Colorectal Cancers
[作者：Zagani, R; Hamzaoui, N; Cacheux, W; De Reynies, A; Terris, B; Chaussade, S; Romagnolo, B; Perret, C; Lamarque, D,期刊：Gastroenterology, 页码：1358-1366 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Cyclooxygenase-2 inhibitors reduce colon cancer risk by mechanisms that are not fully understood. We performed microarray analysis of adenomas from Apc(Delta 14/+) mice to identify genes that respond t...
- Increased Mortality Risk in Patients With Phenotypic Hereditary Hemochromatosis But Not in Their First-Degree Relatives
[作者：Elmberg, M; Hultcrantz, R; Ebrahim, F; Olsson, S; Lindgren, S; Loof, L; Stal, P; Wallerstedt, S; Almer, S; Sandberg-Gertzen, H; Ekbom, A; Askling, J,期刊：Gastroenterology, 页码：1301-1309 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Hereditary hemochromatosis (HH) is an autosomal-recessive disorder characterized by iron overload. Relatives of HH patients were screened and those with HH-associated mutations and an increased iron lo...
- Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome
[作者：Buhner, S; Li, Q; Vignali, S; Barbara, G; De Giorgio, R; Stanghellini, V; Cremon, C; Zeller, F; Langer, R; Daniel, H; Michel, K; Schemann, M,期刊：Gastroenterology, 页码：1425-1434 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons. METHODS: Voltage sensit...
- Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease
[作者：Syn, WK; Jung, YM; Omenetti, A; Abdelmalek, M; Guy, CD; Yang, L; Wang, JB; Witek, RP; Fearing, CM; Pereira, TA; Teaberry, V; Choi, SS; Conde-Vancells, J; Karaca, GF; Diehl, AM,期刊：Gastroenterology, 页码：1478-1488 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Repair responses define the ultimate outcomes of liver disease. This study evaluated the hypothesis that fibrogenic repair in nonalcoholic fatty liver disease (NAFLD) is mediated by Hedgehog (Hh) pathw...
- Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis
[作者：Du, YC; Oshima, H; Oguma, K; Kitamura, T; Itadani, H; Fujimura, T; Piao, YS; Yoshimoto, T; Minamoto, T; Kotani, H; Taketo, MM; Oshima, M,期刊：Gastroenterology, 页码：1346-1357 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was design...
- Diet Synergistically Affects Helicobacter pylori-Induced Gastric Carcinogenesis in Nonhuman Primates
[作者：Liu, H; Merrell, DS; Semino-Mora, C; Goldman, M; Rahman, A; Mog, S; Dubois, A,期刊：Gastroenterology, 页码：1367-1379 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Gastric cancer results from a combination of Helicobacter pylori (H pylori) infection, exposure to dietary carcinogens, and predisposing genetic make-up. Because the role of these factors in gastric ca...
- Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection
[作者：Dunn, C; Peppa, D; Khanna, P; Nebbia, G; Jones, M; Brendish, N; Lascar, RM; Brown, D; Gilson, RJ; Tedder, RJ; Dusheiko, GM; Jacobs, M; Klenerman, P; Maini, MK,期刊：Gastroenterology, 页码：1289-1300 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Hepatitis B virus (HBV) causes more than 1 million deaths annually from immune-mediated liver damage. The long incubation period has been difficult to study; by the time most patients present, massive ...
- Multicenter, Randomized, Placebo-Controlled Trial of Amitriptyline in Children With Functional Gastrointestinal Disorders
[作者：Saps, M; Youssef, N; Miranda, A; Nurko, S; Hyman, P; Cocjin, J; Di Lorenzo, C,期刊：Gastroenterology, 页码：1261-1269 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: There are no prospective, multicenter, double-blind, placebo-con trolled, randomized pharmacologic trials for the treatment of pain-predominant functional gastrointestinal disorders in children. The ai...
- Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice
[作者：Higashiyama, R; Moro, T; Nakao, S; Mikami, K; Fukumitsu, H; Ueda, Y; Ikeda, K; Adachi, E; Bou-Gharios, G; Okazaki, I; Inagaki, Y,期刊：Gastroenterology, 页码：1459-1466 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Recent studies have reported that bone marrow (BM)-derived cells migrating into fibrotic liver tissue exhibit a myofibroblast-like phenotype and may participate in the progression of liver fibrosis. Ho...
- Toll-Like Receptor 4-Mediated Regulation of Spontaneous Helicobacter-Dependent Colitis in IL-10-Deficient Mice
[作者：Matharu, KS; Mizoguchi, E; Cotoner, CA; Nguyen, DD; Mingle, B; Iweala, OI; Mcbee, ME; Stefka, AT; Prioult, G; Haigis, KM; Bhan, AK; Snapper, SB; Murakami, H; Schauer, DB; Reinecker, HC; Mizoguchi, A; Nagler, CR,期刊：Gastroenterology, 页码：1380-1390 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: The commensal microbiota is believed to have an important role in regulating immune responsiveness and preventing intestinal inflammation. Intestinal microbes produce signals that regulate inflammation...
- Visualizing Hepatitis C Virus Infections in Human Liver by Two-Photon Microscopy
[作者：Liang, YQ; Shilagard, T; Xiao, SY; Snyder, N; Lau, D; Cicalese, L; Weiss, H; Vargas, G; Lemon, SM,期刊：Gastroenterology, 页码：1448-1458 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Although hepatitis C virus (HCV) is a common cause of cirrhosis and liver cancer, efforts to understand the pathogenesis of HCV infection have been limited by the low abundance of viral proteins expres...
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