- Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin
[作者:Nevzorova, YA; Tschaharganeh, D; Gassler, N; Geng, Y; Weiskirchen, R; Sicinski, P; Trautwein, C; Liedtke, C,期刊:Gastroenterology, 页码:691-703 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: E-cyclins control the transition of quiescent cells into the cell cycle. Two E-cyclins, CcnE1 and CcnE2, have been described, but their specific contributions to cell cycle reentry in vivo are poorly u...
- Delayed Radionucleotide Gastric Emptying Studies Predict Morbidity in Diabetics With Symptoms of Gastroparesis
[作者:Hyett, B; Martinez, FJ; Gill, BM; Mehra, S; Lembo, A; Kelly, CP; Leffler, DA,期刊:Gastroenterology, 页码:445-452 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: The aim of this study was to evaluate the prognostic value of gastric emptying studies on the morbidity associated with diabetic gastroparesis. METHODS: This was a parallel cohort study of 3 groups. Gr...
- Increased Colorectal Cancer Incidence in Obligate Carriers of Heterozygous Mutations in MUTYH
[作者:Jones, N; Vogt, S; Nielsen, M; Christian, D; Wark, PA; Eccles, D; Edwards, E; Evans, DG; Maher, ER; Vasen, HF; Hes, FJ; Aretz, S; Sampson, JR,期刊:Gastroenterology, 页码:489-494 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal...
- Bone Marrow Progenitor Cells Repair Rat Hepatic Sinusoidal Endothelial Cells After Liver Injury
[作者:Harb, R; Xie, GH; Lutzko, C; Guo, YM; Wang, XD; Hill, CK; Kanel, GC; Deleve, LD,期刊:Gastroenterology, 页码:704-712 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Damage to hepatic sinusoidal endothelial cells (SECs) initiates sinusoidal obstruction syndrome (SOS), which is most commonly a consequence of myeloablative chemoirradiation or ingestion of pyrrolizidi...
- Increased Short- and Long-Term Risk of Inflammatory Bowel Disease After Salmonella or Campylobacter Gastroenteritis
[作者:Gradel, KO; Nielsen, HL; Schonheyder, HC; Ejlertsen, T; Kristensen, B; Nielsen, H,期刊:Gastroenterology, 页码:495-501 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Various commensal enteric and potentially pathogenic bacteria may be involved in the pathogenesis of inflammatory bowel diseases (IBD). We compared the risk of IBD between a cohort of patients with doc...
- Infection in Patients With Severe Alcoholic Hepatitis Treated With Steroids: Early Response to Therapy Is the Key Factor
[作者:Louvet, A; Wartel, F; Castel, H; Dharancy, S; Hollebecque, A; Canva-Delcambre, V; Deltenre, P; Mathurin, P,期刊:Gastroenterology, 页码:541-548 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: In severe (Maddrey score >= 32) alcoholic hepatitis (AH), infection is classically viewed as a contraindication for corticosteroids, although specific data are lacking. This study's aims were (1) to ev...
- Direct-to-Consumer and Physician Promotion of Tegaserod Correlated With Physician Visits, Diagnoses, and Prescriptions
[作者:Dorn, SD; Farley, JF; Hansen, RA; Shah, ND; Sandler, RS,期刊:Gastroenterology, 页码:518-524 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Direct-to-consumer advertisement (DTCA) and physician promotion of drugs can influence patient and physician behaviors. We sought to determine the relationship between promotion of tegaserod and the nu...
- Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer
[作者:Biankin, AV; Kench, JG; Colvin, EK; Segara, D; Scarlett, CJ; Nguyen, NQ; Chang, DK; Morey, AL; Lee, CS; Pinese, M; Kuo, SCL; Susanto, JM; Cosman, PH; Lindeman, GJ; Visvader, JE; Nguyen, TV; Merrett, ND; Warusavitarne, J; Musgrove, EA; Henshall, SM; Sutherland, RL,期刊:Gastroenterology, 页码:558-568 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Current methods of preoperative staging and predicting outcome following pancreatectomy for pancreatic cancer (PC) are inadequate. We evaluated the utility of multiple biomarkers from distinct biologic...
- Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome
[作者:Yang, LY; Lu, XH; Nossa, CW; Francois, F; Peek, RM; Pei, ZH,期刊:Gastroenterology, 页码:588-597 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Gastroesophageal reflux causes inflammation and intestinal metaplasia and its downstream sequelum adenocarcinoma in the distal esophagus. The incidence of esophageal adenocarcinoma has increased approx...
- Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells
[作者:Gee, HY; Kim, YW; Jo, MJ; Namkung, W; Kim, JY; Park, HW; Kim, KS; Kim, H; Baba, A; Yang, J; Kim, E; Kim, KH; Lee, MG,期刊:Gastroenterology, 页码:607-617 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Vasoactive intestinal polypeptide (VIP) is a principal regulator of fluid and electrolyte secretion in the gastrointestinal system. The VIP type-1 receptor (VPAC(1)), a class II G-protein-coupled recep...
- Profile of Tumor Antigen-Specific CD8 T Cells in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma
[作者:Gehring, AJ; Ho, ZZ; Tan, AT; Aung, MO; Lee, KH; Tan, KC; Lim, SG; Bertoletti, A,期刊:Gastroenterology, 页码:682-690 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Tumor and viral antigens are expressed by hepatocellular carcinoma (HCC) in patients with chronic hepatitis B, but little is known about the immunodominance and function of tumor- and virus-specific CD...
- Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease
[作者:Mathurin, P; Hollebecque, A; Arnalsteen, L; Buob, D; Leteurtre, E; Caiazzo, R; Pigeyre, M; Verkindt, H; Dharancy, S; Louvet, A; Romon, M; Pattou, F,期刊:Gastroenterology, 页码:532-540 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Severe obesity is implicated in development of nonalcoholic fatty liver disease (NAFLD). Bariatric surgery induces weight loss and increases survival time of obese patients, but little is known about i...
- Salmonella Induces Flagellin- and MyD88-Dependent Migration of Bacteria-Capturing Dendritic Cells Into the Gut Lumen
[作者:Arques, JL; Hautefort, I; Ivory, K; Bertelli, E; Regoli, M; Clare, S; Hinton, JCD; Nicoletti, C,期刊:Gastroenterology, 页码:579-587 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Intestinal dendritic cells (DCs) sample bacteria, such as Salmonella, by extending cellular processes into the lumen to capture bacteria and shuttle them across the epithelium; however, direct evidence...
- Selective Blockade of DCAMKL-1 Results in Tumor Growth Arrest by a Let-7a MicroRNA-Dependent Mechanism
[作者:Sureban, SM; May, R; Ramalingam, S; Subramaniam, D; Natarajan, G; Anant, S; Houchen, CW,期刊:Gastroenterology, 页码:649-659 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression. The tumor suppressor miRNA let-7a has been reported to be inhibited posttranscriptionally in embryonic stem cells and in human canc...
- Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning
[作者:Kolterud, A; Grosse, AS; Zacharias, WJ; Walton, KD; Kretovich, KE; Madison, BB; Waghray, M; Ferris, JE; Hu, C; Merchant, JL; Dlugosz, AA; Kottmann, AH; Gumucio, DL,期刊:Gastroenterology, 页码:618-628 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: Hedgehog signaling is critical in gastrointestinal patterning. Mice deficient in Hedgehog signaling exhibit abnormalities that mirror deformities seen in the human VACTERL (vertebral, anal, cardiac, tr...
- Weight-Related Effects on Disease Progression in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial
[作者:Everhart, JE; Lok, AS; Kim, HY; Morgan, TR; Lindsay, KL; Chung, RT; Bonkovsky, HL; Ghany, MG,期刊:Gastroenterology, 页码:549-557 , 文章类型: Article,,卷期:2009年137-2]
- BACKGROUND & AIMS: With the limited efficacy of current therapy for chronic hepatitis C, modifiable risk factors for liver disease progression are important to identify. Because obesity is associated with liver disease, ...
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