- Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury
[作者：Schneider, M; Van Geyte, K; Fraisl, P; Kiss, J; Aragones, J; Mazzone, M; Mairbaurl, H; De Bock, K; Jeoung, NH; Mollenhauer, M; Georgiadou, M; Bishop, T; Roncal, C; Sutherland, A; Jordan, B; Gallez, B; Weitz, J; Harris, RA; Maxwell, P; Baes, M; Ratcliffe, P; Carmeliet, P,期刊：Gastroenterology, 页码：1143-U438 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We ...
- CLINICAL ADVANCES IN LIVER, PANCREAS, AND BILIARY TRACT
[作者：Valenti, L; Fracanzani, AL; Bugianesi, E; Dongiovanni, P; Galmozzi, E; Vanni, E; Canavesi, E; Lattuada, E; Roviaro, G; Marchesini, G; Fargion, S,期刊：Gastroenterology, 页码：905-912 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Mutations in the hemochromatosis gene (HFE) (C282Y and H63D) lead to parenchymal iron accumulation, hemochromatosis, and liver damage. We investigated whether these factors also contribute to the progr...
- Low Risk of Colorectal Cancer and Advanced Adenomas More Than 10 Years After Negative Colonoscopy
[作者：Brenner, H; Haug, U; Arndt, V; Stegmaier, C; Altenhofen, L; Hoffmeister, M,期刊：Gastroenterology, 页码：870-876 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening...
- An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents
[作者：Kucherlapati, MH; Lee, K; Nguyen, AA; Clark, AB; Hou, H; Rosulek, A; Li, H; Yang, K; Fan, KH; Lipkin, M; Bronson, RT; Jelicks, L; Kunkel, TA; Kucherlapati, R; Edelmann, W,期刊：Gastroenterology, 页码：993-U243 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and II and sporadic colorectal cancers. Msh2(null) mice predominantly develop lymphoma and do not accurately recapitulate th...
- Effect of Puberty Onset on Spontaneous Hepatitis B Virus e Antigen Seroconversion in Men
[作者：Wu, JF; Tsai, WY; Hsu, HY; Ni, YH; Chen, HL; Tsuei, DJ; Chang, MH,期刊：Gastroenterology, 页码：942-U178 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND: Male predominance is a remarkable phenomenon in hepatitis B virus (HBV)-related liver disease. This study elucidated the effects of puberty on spontaneous hepatitis B virus e antigen (HBeAg) seroconversion in...
- Comparison of Probe-Based Confocal Laser Endomicroscopy With Virtual Chromoendoscopy for Classification of Colon Polyps
[作者：Buchner, AM; Shahid, MW; Heckman, MG; Krishna, M; Ghabril, M; Hasan, M; Crook, JE; Gomez, V; Raimondo, M; Woodward, T; Wolfsen, HC; Wallace, MB,期刊：Gastroenterology, 页码：834-842 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Probe-based confocal laser endomicroscopy (pCLE) allows in vivo imaging of tissue at micron resolution. Virtual chromoendoscopy systems, such as Fujinon intelligent color enhancement and narrow band im...
- Efficacy of Linaclotide for Patients With Chronic Constipation
[作者：Lembo, AJ; Kurtz, CB; MacDougall, JE; Lavins, BJ; Currie, MG; Fitch, DA; Jeglinski, BI; Johnston, JM,期刊：Gastroenterology, 页码：886-U120 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety ...
- Antimetastatic Role of Smad4 Signaling in Colorectal Cancer
[作者：Zhang, BX; Halder, SK; Kashikar, ND; Cho, YJ; Datta, A; Gorden, DL; Datta, PK,期刊：Gastroenterology, 页码：969-U220 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Transforming growth factor (TGF)-beta signaling occurs through Smads 2/3/4, which translocate to the nucleus to regulate transcription; TGF-beta has tumor-suppressive effects in some tumor models and p...
- Conditional Deletion of I kappa B-Kinase-beta Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
[作者：Shibata, W; Takaishi, S; Muthupalani, S; Pritchard, DM; Whary, MT; Rogers, AB; Fox, JG; Betz, KS; Kaestner, KH; Karin, M; Wang, TC,期刊：Gastroenterology, 页码：1022-U295 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: The nuclear factor kappa B (NF-kappa B)/I kappa B-kinase-beta (IKK beta) pathway has been shown to represent a key link between inflammation and cancer, inducing pro-inflammatory cytokines in myeloid c...
- Galectin-3 Increases Gastric Cancer Cell Motility by Up-regulating Fascin-1 Expression
[作者：Kim, SJ; Choi, IJ; Cheong, TC; Lee, SJ; Lotan, R; Park, SH; Chun, KH,期刊：Gastroenterology, 页码：1035-U308 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Galectin-3 is a beta-galactoside-binding protein that increases gastric cancer cell motility in response to integrin signaling and is highly expressed in gastric tumor cells. Galectin-3 induces cytoske...
- A Model to Study the Phenotypic Changes of Interstitial Cells of Cajal in Gastrointestinal Diseases
[作者：Ro, S; Park, C; Jin, JL; Zheng, HL; Blair, PJ; Redelman, D; Ward, SM; Yan, W; Sanders, KM,期刊：Gastroenterology, 页码：1068-U347 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Interstitial cells of Cajal (ICC) express the receptor tyrosine kinase, KIT, the receptor for stem cell factor. In the gastrointestinal (GI) tract, ICC are pacemaker cells that generate spontaneous ele...
- Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
[作者：Karlsen, TH; Franke, A; Melum, E; Kaser, A; Hov, JR; Balschun, T; Lie, BA; Bergquist, A; Schramm, C; Weismuller, TJ; Gotthardt, D; Rust, C; Philipp, EER; Fritz, T; Henckaerts, L; Weersma, RK; Stokkers, P; Ponsioen, CY; Wijmenga, C; Sterneck, M; Nothnagel, M; Hampe, J; Teufel, A; Runz, H; Rosenstiel, P; Stiehl, A; Vermeire, S; Beuers, U; Manns, MP; Schrumpf, E; Boberg, KM; Schreiber, S,期刊：Gastroenterology, 页码：1102-1111 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single nucleotide polymorphism (SNP) markers. METHODS: A to...
- Helicobacter pylori Immune Escape Is Mediated by Dendritic Cell-Induced Treg Skewing and Th17 Suppression in Mice
[作者：Kao, JY; Zhang, M; Miller, MJ; Mills, JC; Wang, BM; Liu, MC; Eaton, KA; Zou, WP; Berndt, BE; Cole, TS; Takeuchi, T; Owyang, SY; Luther, J,期刊：Gastroenterology, 页码：1046-1054 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Helicobacter pylori infection increases gastric regulatory T cell (Treg) response, which may contribute to H pylori immune escape. We hypothesize that H pylori directs Treg skewing by way of dendritic ...
- Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection
[作者：Chen, LM; Borozan, I; Sun, J; Guindi, M; Fischer, S; Feld, J; Anand, N; Heathcote, J; Edwards, AM; McGilvray, ID,期刊：Gastroenterology, 页码：1123-U415 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: Chronic hepatitis C virus (CHC) infection is treated with interferon/ribavirin, but only a subset of patients respond. Treatment nonresponders have marked pretreatment up-regulation of a subset of inte...
- Induction of p53 Renders ATM-Deficient Mice Refractory to Hepatocarcinogenesis
[作者：Teoh, N; Pyakurel, P; Dan, YY; Swisshelm, K; Hou, J; Mitchell, C; Fausto, N; Gu, YS; Farrell, G,期刊：Gastroenterology, 页码：1155-U451 , 文章类型： Article，,卷期：2010年138-3]
- BACKGROUND & AIMS: p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse. Ataxia Telangiectasia Mutate...
|