- B Cells Suppress the Inflammatory Response in a Mouse Model of Primary Biliary Cirrhosis
[作者:Moritoki, Y; Zhang, WC; Tsuneyama, K; Yoshida, K; Wakabayashi, K; Yang, GX; Bowlus, C; Ridgway, WM; Ueno, Y; Ansari, AA; Coppel, RL; Mackay, IR; Flavell, RA; Gershwin, ME; Lian, ZX,期刊:Gastroenterology, 页码:1037-1047 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Mice that express a dominant-negative form of transforming growth factor-beta receptor restricted to T cells (dnTGF-beta RII) develop anti-mitochonctrial antibodies and liver inflammation similar to hu...
- Glucocorticoids and Tumor Necrosis Factor-alpha Synergize to Induce Absorption by the Epithelial Sodium Channel in the Colon
[作者:Bergann, T; Zeissig, S; Fromm, A; Richter, JF; Fromm, M; Schulzke, JD,期刊:Gastroenterology, 页码:933-942 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: The epithelial sodium channel (ENaC) mediates electrogenic sodium absorption in distal colon. In patients with inflammatory bowel disease (IBD), ENaC induction is impaired, mainly through transcription...
- Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells
[作者:Sakiyama, T; Musch, MW; Ropeleski, MJ; Tsubouchi, H; Chang, EB,期刊:Gastroenterology, 页码:924-932 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Glutamine plays a protective role in intestinal cells during physiologic stress; however, the protection mechanisms are not fully understood. Autophagy functions in bulk degradation of cellular compone...
- Abnormal Nuclear Pore Formation Triggers Apoptosis in the Intestinal Epithelium of elys-Deficient Zebrafish
[作者:de Jong-Curtain, TA; Parslow, AC; Trotter, AJ; Hall, NE; Verkade, H; Tabone, T; Christie, EL; Crowhurst, MO; Layton, JE; Shepherd, IT; Nixon, SJ; Parton, RG; Zon, LI; Stainier, DYR; Lieschke, GJ; Heath, JK,期刊:Gastroenterology, 页码:902-911 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Zebrafish mutants generated by ethylnitrosourea-mutagenesis provide a powerful toot for dissecting the genetic regulation of developmental processes, including organogenesis. One zebrafish mutant, "flo...
- Diagnosing Mild Enteropathy Celiac Disease: A Randomized, Controlled Clinical Study
[作者:Kurppa, K; Collin, P; Viljamaa, M; Haimila, K; Saavalainen, P; Partanen, J; Laurila, K; Huhtala, H; Paasikivi, K; Maki, M; Kaukinen, K,期刊:Gastroenterology, 页码:816-823 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: The diagnostic criteria for celiac disease require small-bowel mucosal villous atrophy with crypt hyperplasia (Marsh III). However, mucosal damage develops gradually and patients may evince clinical sy...
- Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
[作者:Basma, H; Soto-Gutierrez, A; Yannam, GR; Liu, LP; Ito, R; Yamamoto, T; Ellis, E; Carson, SD; Sato, S; Chen, Y; Muirhead, D; Navarro-Alvarez, N; Wong, RJ; Roy-Chowdhury, J; Platt, JL; Mercer, DF; Miller, JD; Strom, SC; Kobayashi, N; Fox, IJ,期刊:Gastroenterology, 页码:990-999 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: The ability to obtain unlimited numbers of human hepatocytes would improve the development of cell-based therapies for liver diseases, facilitate the study of liver biology, and improve the early stage...
- S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis
[作者:Tomasi, ML; Iglesias-Ara, A; Yang, HP; Ramani, K; Feo, F; Pascale, MR; Martinez-Chantar, ML; Mato, JM; Lu, SC,期刊:Gastroenterology, 页码:1025-1036 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Genomic instability participates in the pathogenesis of hepatocellular carcinoma (HCC). Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the base excision repair of premutagenic apurinic/ap...
- Sall4 Regulates Cell Fate Decision in Fetal Hepatic Stem/Progenitor Cells
[作者:Oikawa, T; Kamiya, A; Kakinuma, S; Zeniya, M; Nishinakamura, R; Tajiri, H; Nakauchi, H,期刊:Gastroenterology, 页码:1000-1011 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Fetal hepatic stem/progenitor cells, called hepatoblasts, differentiate into both hepatocytes and cholangiocytes. The molecular mechanisms regulating this lineage segmentation process remain unknown. S...
- The Association Between Alcohol and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma
[作者:Anderson, LA; Cantwell, MM; Watson, RGP; Johnston, BT; Murphy, SJ; Ferguson, HR; McGuigan, J; Comber, H; Reynolds, JV; Murray, LJ,期刊:Gastroenterology, 页码:799-805 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Alcohol consumption may increase gastroesophageal. reflux symptoms, cause damage to the esophageal mucosa, and/or promote carcinogenesis. However, reports about the association between alcohol and refl...
- Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome
[作者:Zhang, JL; Luo, B; Tang, LP; Wang, YM; Stockard, CR; Kadish, I; Van Groen, T; Grizzle, WE; Ponnazhagan, S; Fallon, MB,期刊:Gastroenterology, 页码:1070-1080 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Hepatopulmonary syndrome (HPS), defined as intrapulmonary vasodilation, occurs in 10%-30% of cirrhotics and increases mortality. In a rat model of HPS induced by common bile duct ligation (CBDL), but n...
- The microRNA-30 Family Is Required for Vertebrate Hepatobiliary Development
[作者:Hand, NJ; Master, ZR; Eauclaire, SF; Weinblatt, DE; Matthews, RP; Friedman, JR,期刊:Gastroenterology, 页码:1081-1090 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: The function of microRNA (miRNA) in liver development is unknown. To address this issue, we characterized miRNA expression in the embryonic mouse liver, performed functional miRNA analysis in zebrafish...
- Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations
[作者:Camargo, SMR; Singer, D; Makrides, V; Huggel, K; Pos, KM; Wagner, CA; Kuba, K; Danilczyk, U; Skovby, F; Kleta, R; Penninger, JM; Verrey, F,期刊:Gastroenterology, 页码:872-882 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Hartnup amino acid transporter B(0)AT1 (SLC6A19) is the major luminal sodium-dependent neutral amino acid transporter of small intestine and kidney proximal tubule. The expression of B(0)AT1 in kidney ...
- TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis
[作者:Dohi, T; Borodovsky, A; Wu, P; Shearstone, JR; Kawashima, R; Runkel, L; Rajman, L; Dong, XW; Scott, ML; Michaelson, JS; Jakubowski, A; Burkly, LC,期刊:Gastroenterology, 页码:912-923 , 文章类型: Article,,卷期:2009年136-3]
- Background and Aims: Tumor necrosis factor (TNF) superfamily members have attracted attention as new therapeutic targets for treating inflammatory disease. TNF-like weak inducer of apoptosis (TWEAK) is a unique, multifun...
- Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling
[作者:Elghazi, L; Weiss, AJ; Barker, DJ; Callaghan, J; Staloch, L; Sandgren, EP; Gannon, M; Adsay, VN; Bernal-Mizrachi, E,期刊:Gastroenterology, 页码:1091-1103 , 文章类型: Article,,卷期:2009年136-3]
- Background & Aims: Extensive evidence suggests that Akt signaling plays an important role in beta-cell mass and function, although its function in the regulation of the different pancreatic fates has not been adequately ...
|