- Angiotensin II Activates I kappa B Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis
[作者:Oakley, F; Teoh, V; Ching-A-Sue, G; Bataller, R; Colmenero, J; Jonsson, JR; Eliopoulos, AG; Watson, MR; Manas, D; Mann, DA,期刊:Gastroenterology, 页码:2334-2344 , 文章类型: Article,,卷期:2009年136-7]
- Background & AimS: The transcription factor nuclear factor-kappa B (NF)-kappa B promotes survival of hepatic myofibroblasts and fibrogenesis through poorly defined mechanisms. We investigated the activities of angiotensi...
- A Cost-Utility Analysis of Ablative Therapy for Barrett's Esophagus
[作者:Inadomi, JM; Somsouk, MA; Madanick, RD; Thomas, JP; Shaheen, NJ,期刊:Gastroenterology, 页码:2101-2114 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Recommendations for patients with Barren's esophagus (BE) include endoscopic surveillance with esophagectomy for early-stage cancer, although new technologies to ablate dysplasia and metaplasia are ava...
- A Multivariable Model Using Advanced Cytologic Methods for the Evaluation of Indeterminate Pancreatobiliary Strictures
[作者:Fritcher, EGB; Kipp, BR; Halling, KC; Oberg, TN; Bryant, SC; Tarrell, RF; Gores, GJ; Levy, MJ; Clayton, AC; Sebo, TJ; Roberts, LR,期刊:Gastroenterology, 页码:2180-2186 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Ancillary cytologic tests including digital image analysis (DIA) and fluorescence in situ hybridization (FISH) have been developed to improve the sensitivity of routine cytology (RC) for the diagnosis ...
- Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma
[作者:Chan, AT; Zauber, AG; Hsu, M; Breazna, A; Hunter, DJ; Rosenstein, RB; Eagle, CJ; Hawk, ET; Bertagnolli, MM,期刊:Gastroenterology, 页码:2127-2136 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Variants in the cytochrome P450 2C9 (CYP2C9) gene are associated with impaired metabolism of celecoxib. We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related respo...
- Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines
[作者:Akazawa, Y; Mott, JL; Bronk, SF; Werneburg, NW; Kahraman, A; Guicciardi, ME; Meng, XW; Kohno, S; Shah, VH; Kaufmann, SH; McNiven, MA; Gores, GJ,期刊:Gastroenterology, 页码:2365-2376 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in hepatocellular carcinoma cells is mediated by lysosomal permeabilization. Our aims were to determine which TRAIL receptor...
- Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacter pylori-Mediated Gastric Epithelial Cell Apoptosis
[作者:Bhattacharyya, A; Chattopadhyay, R; Burnette, BR; Cross, JV; Mitra, S; Ernst, PB; Bhakat, KK; Crowe, SE,期刊:Gastroenterology, 页码:2258-2269 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Helicobacter pylori-induced gastric epithelial cell (GEC) apoptosis is a complex process that includes activation of the tumor suppressor p53. p53-mediated apoptosis involves p53 activation, bax transc...
- Budesonide Is Effective in Treating Lymphocytic Colitis: A Randomized Double-Blind Placebo-Controlled Study
[作者:Miehlke, S; Madisch, A; Karimi, D; Wonschik, S; Kuhlisch, E; Beckmann, R; Morgner, A; Mueller, R; Greinwald, R; Seitz, G; Baretton, G; Stolte, M,期刊:Gastroenterology, 页码:2092-2100 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Budesonide is effective in treating collagenous colitis, but no treatment is established for lymphorytic colitis. We performed a randomized, double-blind, placebo-controlled study to evaluate the effec...
- Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway
[作者:van Dop, WA; Uhmann, A; Wijgerde, M; Sleddens-Linkels, E; Heijmans, J; Offerhaus, GJ; Weerman, MAV; Boeckxstaens, GE; Hommes, DW; Hardwick, JC; Hahn, H; van den Brink, GR,期刊:Gastroenterology, 页码:2195-2203 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: The intestinal epithelium is a homeostatic system in which differentiated cells are in dynamic equilibrium with rapidly cycling precursor cells. Wnt signaling regulates intestinal epithelial precursor ...
- Hepatic Stellate Cells Promote Hepatocyte Engraftment in Rat Liver After Prostaglandin-Endoperoxide Synthase Inhibition
[作者:Enami, Y; Bandi, S; Kapoor, S; Krohn, N; Joseph, B; Gupta, S,期刊:Gastroenterology, 页码:2356-2364 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Hepatic inflammation occurs immediately after cells are transplanted to the liver, but the mechanisms that underlie this process are not fully defined. We examined cyclooxygenase pathways that mediate ...
- The Apc(1322T) Mouse Develops Severe Polyposis Associated With Submaximal Nuclear beta-Catenin Expression
[作者:Pollard, P; Deheragoda, M; Segditsas, S; Lewis, A; Rowan, A; Howarth, K; Willis, L; Nye, E; McCart, A; Mandir, N; Silver, A; Goodlad, R; Stamp, G; Cockman, M; East, P; Spencer-Dene, B; Poulsom, R; Wright, N; Tomlinson, I,期刊:Gastroenterology, 页码:2204-2213 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that t...
- Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine
[作者:Snippert, HJ; van Es, JH; van den Born, M; Begthel, H; Stange, DE; Barker, N; Clevers, H,期刊:Gastroenterology, 页码:2187-2194 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Prominin-1(Prom1)/CD133 is used, alone or in combination with other cell surface markers, to identify and isolate stem cells from various adult tissues. We recently identified leucine-rich-repeat-conta...
- Quantification of Epigenetic and Genetic 2nd Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression
[作者:Oliveira, C; Sousa, S; Pinheiro, H; Karam, R; Bordeira-Carrico, R; Senz, J; Kaurah, P; Carvalho, J; Pereira, R; Gusmao, L; Wen, XG; Cipriano, MA; Yokota, J; Carneiro, F; Huntsman, D; Seruca, R,期刊:Gastroenterology, 页码:2137-2148 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs ...
- Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus
[作者:Dowd, KA; Netski, DM; Wang, XH; Cox, AL; Ray, SC,期刊:Gastroenterology, 页码:2377-2386 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Despite recent characterization of hepatitis C virus-specific neutralizing antibodies, it is not clear to what extent immune pressure from neutralizing antibodies drives viral sequence evolution in viv...
- Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression
[作者:Ghia, JE; Blennerhassett, P; Deng, YK; Verdu, EF; Khan, WI; Collins, SM,期刊:Gastroenterology, 页码:2280-2288 , 文章类型: Article,,卷期:2009年136-7]
- Background & Aims: Patients with inflammatory bowel disease (IBD) frequently also have depression, yet little is known of its role in IBD pathogenesis. We investigated whether the development of depression after the esta...
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