- An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
[作者:Saint-Geniez, M; Kurihara, T; Sekiyama, E; Maldonado, AE; D'Amore, PA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18751-18756 , 文章类型: Article,,卷期:2009年106-44]
- Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF1...
- Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
[作者:Hanaka, H; Pawelzik, SC; Johnsen, JI; Rakonjac, M; Terawaki, K; Rasmuson, A; Sveinbjornsson, B; Schumacher, MC; Hamberg, M; Samuelsson, B; Jakobsson, PJ; Kogner, P; Radmark, O,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18757-18762 , 文章类型: Article,,卷期:2009年106-44]
- There is strong evidence for a role of prostaglandin E-2 (PGE(2)) in cancer cell proliferation and tumor development. In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be...
- T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase
[作者:Al-Qusairi, L; Weiss, N; Toussaint, A; Berbey, C; Messaddeq, N; Kretz, C; Sanoudou, D; Beggs, AH; Allard, B; Mandel, JL; Laporte, J; Jacquemond, V; Buj-Bello, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18763-18768 , 文章类型: Article,,卷期:2009年106-44]
- Skeletal muscle contraction is triggered by the excitation-contraction (E-C) coupling machinery residing at the triad, a membrane structure formed by the juxtaposition of T-tubules and sarcoplasmic reticulum (SR) cistern...
- Adenoviral transfer of HIF-1 alpha enhances vascular responses to critical limb ischemia in diabetic mice
[作者:Sarkar, K; Fox-Talbot, K; Steenbergen, C; Bosch-Marce, M; Semenza, GL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18769-18774 , 文章类型: Article,,卷期:2009年106-44]
- Diabetes is a major risk factor for ischemic disease. Treatment options for diabetic patients with peripheral arterial disease when revascularization is not possible are limited, resulting in a high incidence of limb amp...
- An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition
[作者:Ohigashi, Y; Ma, CL; Jing, XH; Balannick, V; Pinto, LH; Lamb, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18775-18779 , 文章类型: Article,,卷期:2009年106-44]
- Influenza A virus M2 (A/M2) and the influenza B virus BM2 are both small integral membrane proteins that form proton-selective ion channels. Influenza A virus A/M2 channel is the target of the antiviral drug amantadine (...
- HPV E6 protein interacts physically and functionally with the cellular telomerase complex
[作者:Liu, XF; Dakic, A; Zhang, YY; Dai, YH; Chen, RX; Schlegel, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18780-18785 , 文章类型: Article,,卷期:2009年106-44]
- Telomerase activation is critical for the immortalization of primary human keratinocytes by the high-risk HPV E6 and E7 oncoproteins, and this activation is mediated in part by E6-induction of the hTERT promoter. E6 indu...
- Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection
[作者:Kantor, B; Ma, H; Webster-Cyriaque, J; Monahan, PE; Kafri, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18786-18791 , 文章类型: Article,,卷期:2009年106-44]
- Integration of HIV-1 linear DNA into the host chromatin is an essential step in the viral life cycle. However, the majority of reverse-transcribed, nuclear-imported viral genomes remain episomal, either as linear or circ...
- Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump
[作者:Vandecaetsbeek, I; Trekels, M; De Maeyer, M; Ceulemans, H; Lescrinier, E; Raeymaekers, L; Wuytack, F; Vangheluwe, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18533-18538 , 文章类型: Article,,卷期:2009年106-44]
- Sarco(endo) plasmic reticulum Ca2+ ATPase (SERCA) Ca2+ transporters pump cytosolic Ca2+ into the endoplasmic reticulum, maintaining a Ca2+ gradient that controls vital cell functions ranging from proliferation to death. ...
- An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
[作者:Debler, EW; Muller, R; Hilvert, D; Wilson, IA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18539-18544 , 文章类型: Article,,卷期:2009年106-44]
- Design of catalysts featuring multiple functional groups is a desirable, yet formidable goal. Antibody 13G5, which accelerates the cleavage of unactivated benzisoxazoles, is one of few artificial enzymes that harness an ...
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