- Visually evoked activity in cortical cells imaged in freely moving animals
[作者:Sawinski, J; Wallace, DJ; Greenberg, DS; Grossmann, S; Denk, W; Kerr, JND,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19557-19562 , 文章类型: Article,,卷期:2009年106-46]
- We describe a miniaturized head-mounted multiphoton microscope and its use for recording Ca2+ transients from the somata of layer 2/3 neurons in the visual cortex of awake, freely moving rats. Images contained up to 20 n...
- Stability of muscle synergies for voluntary actions after cortical stroke in humans
[作者:Cheung, VCK; Piron, L; Agostini, M; Silvoni, S; Turolla, A; Bizzi, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19563-19568 , 文章类型: Article,,卷期:2009年106-46]
- Production of voluntary movements relies critically on the functional integration of several motor cortical areas, such as the primary motor cortex, and the spinal circuitries. Surprisingly, after almost 40 years of rese...
- Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes
[作者:Guo, BP; Teneberg, S; Munch, R; Terunuma, D; Hatano, K; Matsuoka, K; Angstrom, J; Boren, T; Bergstrom, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19280-19285 , 文章类型: Article,,卷期:2009年106-46]
- A hallmark of acute relapsing fever borreliosis is severe bacteremia. Some Borrelia species, such as B. duttonii and B. crocidurae, associate with erythrocytes and induce aggregation recognized as erythrocyte rosetting. ...
- Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain
[作者:Gelinas, AD; Paschini, M; Reyes, FE; Heroux, A; Batey, RT; Lundblad, V; Wuttke, DS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19298-19303 , 文章类型: Article,,卷期:2009年106-46]
- Telomeres must be capped to preserve chromosomal stability. The conserved Stn1 and Ten1 proteins are required for proper capping of the telomere, although the mechanistic details of how they contribute to telomere mainte...
- Functional genomic screens identify CINP as a genome maintenance protein
[作者:Lovejoy, CA; Xu, X; Bansbach, CE; Glick, GG; Zhao, RX; Ye, F; Sirbu, BM; Titus, LC; Shyr, Y; Cortez, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19304-19309 , 文章类型: Article,,卷期:2009年106-46]
- The DNA damage response (DDR) has a critical role in maintaining genome integrity and serves as a barrier to tumorigenesis by promoting cell-cycle arrest, DNA repair, and apoptosis. The DDR is activated not only by genot...
- A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene
[作者:Chang, B; Grau, T; Dangel, S; Hurd, R; Jurklies, B; Sener, EC; Andreasson, S; Dollfus, H; Baumann, B; Bolz, S; Artemyev, N; Kohl, S; Heckenlively, J; Wissinger, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19581-19586 , 文章类型: Article,,卷期:2009年106-46]
- Retinal cone photoreceptors mediate fine visual acuity, daylight vision, and color vision. Congenital hereditary conditions in which there is a lack of cone function in humans cause achromatopsia, an autosomal recessive ...
- Oncomodulin links inflammation to optic nerve regeneration
[作者:Yin, YQ; Cui, Q; Gilbert, HY; Yang, Y; Yang, ZY; Berlinicke, C; Li, ZW; Zaverucha-do-Valle, C; He, HM; Petkova, V; Zack, DJ; Benowitz, LI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19587-19592 , 文章类型: Article,,卷期:2009年106-46]
- The inflammatory response that accompanies central nervous system (CNS) injury can affect neurological outcome in both positive and negative ways. In the optic nerve, a CNS pathway that normally fails to regenerate when ...
- Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
[作者:Abi-Mosleh, L; Infante, RE; Radhakrishnan, A; Goldstein, JL; Brown, MS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19316-19321 , 文章类型: Article,,卷期:2009年106-46]
- A handoff model has been proposed to explain the egress from lysosomes of cholesterol derived from receptor-mediated endocytosis of LDL. Cholesterol is first bound by soluble Niemann-Pick C2 (NPC2) protein, which hands o...
- Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks
[作者:Rodriguez, JA; Lopez, MA; Thayer, MC; Zhao, YZ; Oberholzer, M; Chang, DD; Kisalu, NK; Penichet, ML; Helguera, G; Bruinsma, R; Hill, KL; Miao, JW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19322-19327 , 文章类型: Article,,卷期:2009年106-46]
- Trypanosoma brucei, a parasitic protist with a single flagellum, is the causative agent of African sleeping sickness. Propulsion of T. brucei was long believed to be by a drill-like, helical motion. Using millisecond dif...
- Kinetic enhancement of NF-kappa B center dot DNA dissociation by I kappa B alpha
[作者:Bergqvist, S; Alverdi, V; Mengel, B; Hoffmann, A; Ghosh, G; Komives, EA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19328-19333 , 文章类型: Article,,卷期:2009年106-46]
- A hallmark of the NF-kappa B transcription response to inflammatory cytokines is the remarkably rapid rate of robust activation and subsequent signal repression. Although the rapidity of postinduction repression is expla...
- Role of dysbindin in dopamine receptor trafficking and cortical GABA function
[作者:Ji, YY; Yang, F; Papaleo, F; Wang, HX; Gao, WJ; Weinberger, DR; Lu, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19593-19598 , 文章类型: Article,,卷期:2009年106-46]
- Dysbindin has been implicated in the pathogenesis of schizophrenia, but little is known about how dysbindin affects neuronal function in the circuitry underlying psychosis and related behaviors. Using a dysbindin knockou...
- Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans
[作者:Wagner, OI; Esposito, A; Kohler, B; Chen, CW; Shen, CP; Wu, GH; Butkevich, E; Mandalapu, S; Wenzel, D; Wouters, FS; Klopfenstein, DR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19605-19610 , 文章类型: Article,,卷期:2009年106-46]
- Kinesin-3 motor UNC-104/KIF1A is essential for transporting synaptic precursors to synapses. Although the mechanism of cargo binding is well understood, little is known how motor activity is regulated. We mapped function...
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