- Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus
[作者:Scholpp, S; Delogu, A; Gilthorpe, J; Peukert, D; Schindler, S; Lumsden, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19895-19900 , 文章类型: Article,,卷期:2009年106-47]
- During vertebrate brain development, the onset of neuronal differentiation is under strict temporal control. In the mammalian thalamus and other brain regions, neurogenesis is regulated also in a spatially progressive ma...
- Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus
[作者:Ott, CJ; Blackledge, NP; Kerschner, JL; Leir, SH; Crawford, GE; Cotton, CU; Harris, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19934-19939 , 文章类型: Article,,卷期:2009年106-47]
- The regulated expression of large human genes can depend on long-range interactions to establish appropriate three-dimensional structures across the locus. The cystic fibrosis transmembrane conductance regulator (CFTR) g...
- Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
[作者:Hailfinger, S; Lenz, G; Ngo, V; Posvitz-Fejfar, A; Rebeaud, F; Guzzardi, M; Penas, EMM; Dierlamm, J; Chan, WC; Staudt, LM; Thome, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19946-19951 , 文章类型: Article,,卷期:2009年106-47]
- A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein...
- Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies
[作者:van Rood, JJ; Stevens, CE; Smits, J; Carrier, C; Carpenter, C; Scaradavou, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19952-19957 , 文章类型: Article,,卷期:2009年106-47]
- Cord blood (CB) hematopoietic stem cell transplantation can be successful even if donor and recipient are not fully matched for human leukocyte antigens (HLA). This may result from tolerance-inducing events during pregna...
- Highly specialized microbial diversity in hyper-arid polar desert
[作者:Pointing, SB; Chan, YK; Lacap, DC; Lau, MCY; Jurgens, JA; Farrell, RL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19964-19969 , 文章类型: Article,,卷期:2009年106-47]
- The McMurdo Dry Valleys in Antarctica are a cold hyperarid polar desert that present extreme challenges to life. Here, we report a culture-independent survey of multidomain microbial biodiversity in McKelvey Valley, a pr...
- Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor
[作者:Wu, KL; Li, WK; Peng, GQ; Li, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19970-19974 , 文章类型: Article,,卷期:2009年106-47]
- NL63 coronavirus (NL63-CoV), a prevalent human respiratory virus, is the only group I coronavirus known to use angiotensin-converting enzyme 2 (ACE2) as its receptor. Incidentally, ACE2 is also used by group II SARS coro...
- Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
[作者:Belloni, L; Pollicino, T; De Nicola, F; Guerrieri, F; Raffa, G; Fanciulli, M; Raimondo, G; Levrero, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19975-19979 , 文章类型: Article,,卷期:2009年106-47]
- HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Usin...
- Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134
[作者:Grant, CK; Fink, EA; Sundstrom, M; Torbett, BE; Elder, JH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19980-19985 , 文章类型: Article,,卷期:2009年106-47]
- We analyzed antibody responses in sera from feline immunodeficiency virus (FIV)-infected and uninfected cats. A strong antiviral response to the viral surface glycoprotein (SU) was noted in both natural and experimental ...
- Intramolecular amide bonds stabilize pili on the surface of bacilli
[作者:Budzik, JM; Poor, CB; Faull, KF; Whitelegge, JP; He, CA; Schneewind, O,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19992-19997 , 文章类型: Article,,卷期:2009年106-47]
- Gram-positive bacteria elaborate pili and do so without the participation of folding chaperones or disulfide bond catalysts. Sortases, enzymes that cut pilin precursors, form covalent bonds that link pilin subunits and a...
- Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori
[作者:Nossa, CW; Jain, P; Tamilselvam, B; Gupta, VR; Chen, LF; Schreiber, V; Desnoyers, S; Blanke, SR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19998-20003 , 文章类型: Article,,卷期:2009年106-47]
- Modification of eukaryotic proteins is a powerful strategy used by pathogenic bacteria to modulate host cells during infection. Previously, we demonstrated that Helicobacter pylori modify an unidentified protein within m...
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