- The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila
[作者:Fagegaltier, D; Bouge, AL; Berry, B; Poisot, E; Sismeiro, O; Coppee, JY; Theodore, L; Voinnet, O; Antoniewski, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21258-21263 , 文章类型: Article,,卷期:2009年106-50]
- A new class of small RNAs (endo-siRNAs) produced from endogenous double-stranded RNA (dsRNA) precursors was recently shown to mediate transposable element (TE) silencing in the Drosophila soma. These endo-siRNAs might pl...
- Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis
[作者:Schonthaler, HB; Huggenberger, R; Wculek, SK; Detmar, M; Wagner, EF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21264-21269 , 文章类型: Article,,卷期:2009年106-50]
- Although, vascular remodeling is a hallmark of many chronic inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, anti-vascular strategies to treat these conditions have received...
- Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae
[作者:Pinto, SB; Lombardo, F; Koutsos, AC; Waterhouse, RM; Mckay, K; An, CJ; Ramakrishnan, C; Kafatos, FC; Michel, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21270-21275 , 文章类型: Article,,卷期:2009年106-50]
- Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides. However, the molec...
- Vertically integrated, three-dimensional nanowire complementary metal-oxide-semiconductor circuits
[作者:Nam, S; Jiang, XC; Xiong, QH; Ham, D; Lieber, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21035-21038 , 文章类型: Article,,卷期:2009年106-50]
- Three-dimensional (3D), multi-transistor-layer, integrated circuits represent an important technological pursuit promising advantages in integration density, operation speed, and power consumption compared with 2D circui...
- Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration
[作者:Yazinski, SA; Westcott, PMK; Ong, K; Pinkas, J; Peters, RM; Weiss, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21282-21287 , 文章类型: Article,,卷期:2009年106-50]
- In response to DNA damage, checkpoint proteins halt cell cycle progression and promote repair or apoptosis, thereby preventing mutation accumulation and suppressing tumor development. The DNA damage checkpoint protein Hu...
- The regulatory mechanism of Hsp90 alpha secretion and its function in tumor malignancy
[作者:Wang, XF; Song, XM; Zhuo, W; Fu, Y; Shi, HB; Liang, Y; Tong, MM; Chang, GD; Luo, YZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21288-21293 , 文章类型: Article,,卷期:2009年106-50]
- Heat shock protein 90-alpha (Hsp90 alpha) is an intracellular molecular chaperone. However, it can also be secreted with the underlying regulatory mechanism remaining far from clear. Here we show that the secreted Hsp90 ...
- A distinctive role of the leukotriene B-4 receptor BLT1 in osteoclastic activity during bone loss
[作者:Hikiji, H; Ishii, S; Yokomizo, T; Takato, T; Shimizu, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21294-21299 , 文章类型: Article,,卷期:2009年106-50]
- Although leukotriene B-4 (LTB4) is produced in various inflammatory diseases, its functions in bone metabolism remain unknown. Using mice deficient in the high-affinity LTB4 receptor BLT1, we evaluated the roles of BLT1 ...
- Versatile ultrathin nanoporous silicon nitride membranes
[作者:Vlassiouk, I; Apel, PY; Dmitriev, SN; Healy, K; Siwy, ZS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21039-21044 , 文章类型: Article,,卷期:2009年106-50]
- Single-and multiple-nanopore membranes are both highly interesting for biosensing and separation processes, as well as their ability to mimic biological membranes. The density of pores, their shape, and their surface che...
- Ambipolar-transporting coaxial nanotubes with a tailored molecular graphene-fullerene heterojunction
[作者:Yamamoto, Y; Zhang, GX; Jin, WS; Fukushima, T; Ishii, N; Saeki, A; Seki, S; Tagawa, S; Minari, T; Tsukagoshi, K; Aida, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21051-21056 , 文章类型: Article,,卷期:2009年106-50]
- Despite a large steric bulk of C-60, a molecular graphene with a covalently linked C-60 pendant [hexabenzocoronene (HBC)-C-60; 1] self-assembles into a coaxial nanotube whose wall consists of a graphite-like pi-stacked H...
- Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation
[作者:Lamberto, GR; Binolfi, A; Orcellet, ML; Bertoncini, CW; Zweckstetter, M; Griesinger, C; Fernandez, CO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21057-21062 , 文章类型: Article,,卷期:2009年106-50]
- The identification of aggregation inhibitors and the investigation of their mechanism of action are fundamental in the quest to mitigate the pathological consequences of amyloid formation. Here, characterization of the s...
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