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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共74条记录   Extracellular 2 ',3 '-cAMP Is a Source of Adenosine [作者：Jackson, EK; Ren, J; Mi, ZC,期刊：Journal of Biological Chemistry, 页码：33097-33106 , 文章类型： Article，,卷期：2009年284-48] We discovered that renal injury releases 2',3'-cAMP (positional isomer of 3',5'-cAMP) into the interstitium. This finding motivated a novel hypothesis: renal injury leads to activation of an extracellular 2',3'-cAMP-aden... Identification of a Heterogeneous Nuclear Ribonucleoprotein-recognition Region in the HIV Rev Protein [作者：Hadian, K; Vincendeau, M; Maeusbacher, N; Nagel, D; Hauck, SM; Ueffing, M; Loyter, A; Werner, T; Wolff, H; Brack-Werner, R,期刊：Journal of Biological Chemistry, 页码：33384-33391 , 文章类型： Article，,卷期：2009年284-48] The Rev protein is a key regulator of human immunodeficiency virus type 1 (HIV-1) gene expression. Rev is primarily known as an adaptor protein for nuclear export of HIV RNAs. However, Rev also contributes to numerous ot... Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase [作者：Lindsey-Boltz, LA; Sercin, O; Choi, JH; Sancar, A,期刊：Journal of Biological Chemistry, 页码：33107-33114 , 文章类型： Article，,卷期：2009年284-48] ATR (ATM and Rad3-related) initiates a DNA damage signaling pathway in human cells upon DNA damage induced by UV and UV-mimetic agents and in response to inhibition of DNA replication. Genetic data with human cells and i... Multivalency in the Assembly of Intrinsically Disordered Dynein Intermediate Chain [作者：Hall, J; Karplus, PA; Barbar, E,期刊：Journal of Biological Chemistry, 页码：33115-33121 , 文章类型： Article，,卷期：2009年284-48] Dynein light chains are thought to increase binding efficiency of dynein intermediate chain to both dynein heavy chain and dynactin, but their exact role is not clear. Isothermal titration calorimetry and x-ray crystallo... Intracellular Autoactivation of Human Cationic Trypsinogen Mutants Causes Reduced Trypsinogen Secretion and Acinar Cell Death [作者：Kereszturi, E; Sahin-Toth, M,期刊：Journal of Biological Chemistry, 页码：33392-33399 , 文章类型： Article，,卷期：2009年284-48] Mutations in the activation peptide of human cationic trypsinogen have been found in patients with chronic pancreatitis. Previous biochemical studies demonstrated that mutations p.D19A, p.D22G, and p.K23R strongly stimul... Conformational Ensemble Modulates Cooperativity in the Rate-determining Catalytic Step in the E1 Component of the Escherichia coli Pyruvate Dehydrogenase Multienzyme Complex [作者：Kale, S; Jordan, F,期刊：Journal of Biological Chemistry, 页码：33122-33129 , 文章类型： Article，,卷期：2009年284-48] Cooperativity is extensively used by enzymes, particularly those acting at key metabolic branch points, to "fine tune" catalysis. Thus, cooperativity and enzyme catalysis are intimately linked, yet their linkage is poorl... A Biosensor for Fluorescent Determination of ADP with High Time Resolution [作者：Kunzelmann, S; Webb, MR,期刊：Journal of Biological Chemistry, 页码：33130-33138 , 文章类型： Article，,卷期：2009年284-48] Nearly every cellular process requires the presence of ATP. This is reflected in the vast number of enzymes like kinases or ATP hydrolases, both of which cleave the terminal phosphate from ATP, thereby releasing ADP. Des... Triple N-Glycosylation in the Long S5-P Loop Regulates the Activation and Trafficking of the Kv12.2 Potassium Channel [作者：Noma, K; Kimura, K; Minatohara, K; Nakashima, H; Nagao, Y; Mizoguchi, A; Fujiyoshi, Y,期刊：Journal of Biological Chemistry, 页码：33139-33150 , 文章类型： Article，,卷期：2009年284-48] Mammalian voltage-dependent potassium (Kv) channels regulate the excitability of nerve and muscle cells. Kv12.2 features the longest S5-P loop among all known mammalian Kv channels with the most N-linked glycosylation si... Formin-like 1 (FMNL1) Is Regulated by N-terminal Myristoylation and Induces Polarized Membrane Blebbing [作者：Han, YY; Eppinger, E; Schuster, IG; Weigand, LU; Liang, XL; Kremmer, E; Peschel, C; Krackhardt, AM,期刊：Journal of Biological Chemistry, 页码：33409-33417 , 文章类型： Article，,卷期：2009年284-48] The formin protein formin-like 1 (FMNL1) is highly restrictedly expressed in hematopoietic lineage-derived cells and has been previously identified as a tumor-associated antigen. However, function and regulation of FMNL1... Interaction between the SifA Virulence Factor and Its Host Target SKIP Is Essential for Salmonella Pathogenesis [作者：Diacovich, L; Dumont, A; Lafitte, D; Soprano, E; Guilhon, AA; Bignon, C; Gorvel, JP; Bourne, Y; Meresse, S,期刊：Journal of Biological Chemistry, 页码：33151-33160 , 文章类型： Article，,卷期：2009年284-48] SifA is a Salmonella effector that is translocated into infected cells by the pathogenicity island 2-encoded type 3 secretion system. SifA is a critical virulence factor. Previous studies demonstrated that, upon transloc... A Human Vitamin B-12 Trafficking Protein Uses Glutathione Transferase Activity for Processing Alkylcobalamins [作者：Kim, J; Hannibal, L; Gherasim, C; Jacobsen, DW; Banerjee, R,期刊：Journal of Biological Chemistry, 页码：33418-33424 , 文章类型： Article，,卷期：2009年284-48] Pathways for tailoring and processing vitamins into active cofactor forms exist in mammals that are unable to synthesize these cofactors de novo. A prerequisite for intracellular tailoring of alkylcobalamins entering fro... Strong Cooperativity and Loose Geometry between CUB Domains Are the Basis for Procollagen C-Proteinase Enhancer Activity [作者：Kronenberg, D; Vadon-Le Goff, S; Bourhis, JM; Font, B; Eichenberger, D; Hulmes, DJS; Moali, C,期刊：Journal of Biological Chemistry, 页码：33437-33446 , 文章类型： Article，,卷期：2009年284-48] Procollagen C-proteinase enhancers (PCPE-1 and -2) specifically activate bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family during C-terminal processing of fibrillar collagen precurso... Procaspase 8 and Bax Are Up-regulated by Distinct Pathways in Streptococcal Pyrogenic Exotoxin B-induced Apoptosis [作者：Chang, CW; Tsai, WH; Chuang, WJ; Lin, YS; Wu, JJ; Liu, CC; Tsai, PJ; Lin, MT,期刊：Journal of Biological Chemistry, 页码：33195-33205 , 文章类型： Article，,卷期：2009年284-48] We have previously identified integrin alpha(v)beta(3) and Fas as receptors for the streptococcal pyrogenic exotoxin B (SPE B), and G308S, a mutant of SPE B that binds to Fas only. In the current study we found that afte... Generation of Long RNA Chains in Water [作者：Costanzo, G; Pino, S; Ciciriello, F; Di Mauro, E,期刊：Journal of Biological Chemistry, 页码：33206-33216 , 文章类型： Article，,卷期：2009年284-48] The synthesis of RNA chains from 3',5'-cAMP and 3',5'-cGMP was observed. The RNA chains formed in water, at moderate temperatures (40-90 degrees C), in the absence of enzymes or inorganic catalysts. As determined by RNas... Caspase-9 Activation by the Apoptosome Is Not Required for Fas-mediated Apoptosis in Type II Jurkat Cells [作者：Shawgo, ME; Shelton, SN; Robertson, JD,期刊：Journal of Biological Chemistry, 页码：33447-33455 , 文章类型： Article，,卷期：2009年284-48] Activation of executioner caspases during receptor-mediated apoptosis in type II cells requires the engagement of the mitochondrial apoptotic pathway. Although it is well established that recruitment of mitochondria in t... Protein Kinase C delta Supports Survival of MDA-MB-231 Breast Cancer Cells by Suppressing the ERK1/2 Pathway [作者：Lonne, GK; Masoumi, KC; Lennartsson, J; Larsson, C,期刊：Journal of Biological Chemistry, 页码：33456-33465 , 文章类型： Article，,卷期：2009年284-48] Mechanisms that mediate apoptosis resistance are attractive therapeutic targets for cancer. Protein kinase C delta (PKC delta) is considered a pro-apoptotic factor in many cell types. In breast cancer, however, it has sh...