- RNA Helicase Prp43 and Its Co-factor Pfa1 Promote 20 to 18 S rRNA Processing Catalyzed by the Endonuclease Nob1
[作者:Pertschy, B; Schneider, C; Gnadig, M; Schafer, T; Tollervey, D; Hurt, E,期刊:Journal of Biological Chemistry, 页码:35079-35091 , 文章类型: Article,,卷期:2009年284-50]
- Many RNA nucleases and helicases participate in ribosome biogenesis, but how they cooperate with each other is largely unknown. Here we report that in vivo cleavage of the yeast pre-rRNA at site D, the 3'-end of the 18 S...
- Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
[作者:Das, K; Bandwar, RP; White, KL; Feng, JY; Sarafianos, SG; Tuske, S; Tu, XY; Clark, AD; Boyer, PL; Hou, XR; Gaffney, BL; Jones, RA; Miller, MD; Hughes, SH; Arnold, E,期刊:Journal of Biological Chemistry, 页码:35092-35100 , 文章类型: Article,,卷期:2009年284-50]
- K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog R...
- Tensin1 Requires Protein Phosphatase-1 alpha in Addition to RhoGAP DLC-1 to Control Cell Polarization, Migration, and Invasion
[作者:Hall, EH; Daugherty, AE; Choi, CK; Horwitz, AF; Brautigan, DL,期刊:Journal of Biological Chemistry, 页码:34713-34722 , 文章类型: Article,,卷期:2009年284-50]
- Tensin is a family of multidomain scaffold proteins that bind the cytoplasmic tail of beta-integrins and localize to adhesions that anchor stress fibers in cells. Tensin expression is suppressed in cancer, especially met...
- Structure and Mode of Action of Microplusin, a Copper II-chelating Antimicrobial Peptide from the Cattle Tick Rhipicephalus (Boophilus) microplus
[作者:Silva, FD; Rezende, CA; Rossi, DCP; Esteves, E; Dyszy, FH; Schreier, S; Gueiros-Filho, F; Campos, CB; Pires, JR; Daffre, S,期刊:Journal of Biological Chemistry, 页码:34735-34746 , 文章类型: Article,,卷期:2009年284-50]
- Microplusin, a Rhipicephalus (Boophilus) microplus antimicrobial peptide (AMP) is the first fully characterized member of a new family of cysteine-rich AMPs with histidine-rich regions at the N and C termini. In the tick...
- Plumieribetin, a Fish Lectin Homologous to Mannose-binding B-type Lectins, Inhibits the Collagen-binding alpha 1 beta 1 Integrin
[作者:Evangelista, KD; Andrich, F; de Rezende, FF; Niland, S; Cordeiro, MN; Horlacher, T; Castelli, R; Schmidt-Hederich, A; Seeberger, PH; Sanchez, EF; Richardson, M; de Figueiredo, SG; Eble, JA,期刊:Journal of Biological Chemistry, 页码:34747-34759 , 文章类型: Article,,卷期:2009年284-50]
- Recently, a few fish proteins have been described with a high homology to B-type lectins of monocotyledonous plants. Because of their mannose binding activity, they have been ascribed a role in innate immunity. By screen...
- Dynein Light Intermediate Chain in Aspergillus nidulans Is Essential for the Interaction between Heavy and Intermediate Chains
[作者:Zhang, J; Li, SH; Musa, S; Zhou, H; Xiang, X,期刊:Journal of Biological Chemistry, 页码:34760-34768 , 文章类型: Article,,卷期:2009年284-50]
- Cytoplasmic dynein is a complex containing heavy chains (HCs), intermediate chains (ICs), light intermediate chains (LICs), and light chains (LCs). The HCs are responsible for motor activity. The ICs at the tail region o...
- O-GlcNAc Protein Modification in Cancer Cells Increases in Response to Glucose Deprivation through Glycogen Degradation
[作者:Kang, JG; Park, SY; Ji, S; Jang, I; Park, S; Kim, HS; Kim, SM; Yook, JI; Park, YI; Roth, J; Cho, JW,期刊:Journal of Biological Chemistry, 页码:34777-34784 , 文章类型: Article,,卷期:2009年284-50]
- When cellular glucose concentrations fall below normal levels, in general the extent of protein O-GlcNAc modification (O-GlcNAcylation) decreases. However, recent reports demonstrated increased O-GlcNAcylation by glucose...
- Identification and Characterization of Multiple Similar Ligand-binding Repeats in Filamin IMPLICATION ON FILAMIN-MEDIATED RECEPTOR CLUSTERING AND CROSS-TALK
[作者:Ithychanda, SS; Hsu, D; Li, HH; Yan, LD; Liu, DW; Das, M; Plow, EF; Qin, J,期刊:Journal of Biological Chemistry, 页码:35113-35121 , 文章类型: Article,,卷期:2009年284-50]
- The actin-binding protein filamin links membrane receptors to the underlying cytoskeleton. The cytoplasmic domains of these membrane receptors have been shown to bind to various filamin immunoglobulin repeats. Notably, a...
- Novel Mechanisms of Trafficking Defect Caused by KCNQ1 Mutations Found in Long QT Syndrome
[作者:Sato, A; Arimura, T; Makita, N; Ishikawa, T; Aizawa, Y; Ushinohama, H; Aizawa, Y; Kimura, A,期刊:Journal of Biological Chemistry, 页码:35122-35133 , 文章类型: Article,,卷期:2009年284-50]
- Long QT syndrome (LQTS) is a hereditary arrhythmia caused by mutations in genes for cardiac ion channels, including a potassium channel, KvLQT1. Inheritance of LQTS is usually autosomal-dominant, but autosomal-recessive ...
- Splicing Factor Arginine/Serine-rich 17A (SFRS17A) Is an A-kinase Anchoring Protein That Targets Protein Kinase A to Splicing Factor Compartments
[作者:Jarnaess, E; Stokka, AJ; Kvissel, AK; Skalhegg, BS; Torgersen, KM; Scott, JD; Carlson, CR; Tasken, K,期刊:Journal of Biological Chemistry, 页码:35154-35164 , 文章类型: Article,,卷期:2009年284-50]
- Protein kinase A (PKA) is targeted to distinct subcellular localizations by specific protein kinase A anchoring proteins (AKAPs). AKAPs are divided into subclasses based on their ability to bind type I or type II PKA or ...
- Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)
[作者:Mutoh, S; Osabe, M; Inoue, K; Moore, R; Pedersen, L; Perera, L; Rebolloso, Y; Sueyoshi, T; Negishi, M,期刊:Journal of Biological Chemistry, 页码:34785-34792 , 文章类型: Article,,卷期:2009年284-50]
- Upon activation by therapeutics, the nuclear xenobiotic/constitutive active/androstane receptor (CAR) regulates various liver functions ranging from drug metabolism and excretion to energy metabolism. CAR can also be a r...
- Glycan Microarray Analysis of P-type Lectins Reveals Distinct Phosphomannose Glycan Recognition
[作者:Song, XZ; Lasanajak, Y; Olson, LJ; Boonen, M; Dahms, NM; Kornfeld, S; Cummings, RD; Smith, DF,期刊:Journal of Biological Chemistry, 页码:35201-35214 , 文章类型: Article,,卷期:2009年284-50]
- The specificity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for high mannose-type N-glycans of defined structure containing zero, one, or two Man-P-GlcNAc phosphodiester or ...
- Melanoma Antigen Gene Protein-A11 (MAGE-11) F-box Links the Androgen Receptor NH2-terminal Transactivation Domain to p160 Coactivators
[作者:Askew, EB; Bai, SX; Hnat, AT; Minges, JT; Wilson, EM,期刊:Journal of Biological Chemistry, 页码:34793-34808 , 文章类型: Article,,卷期:2009年284-50]
- Androgen-dependent transcriptional activity by the androgen receptor (AR) and its coregulators is required for male reproductive development and function. In humans and other primates, melanoma antigen gene protein-A11 (...
- Genetic Identification of Nascent Peptides That Induce Ribosome Stalling
[作者:Tanner, DR; Cariello, DA; Woolstenhulme, CJ; Broadbent, MA; Buskirk, AR,期刊:Journal of Biological Chemistry, 页码:34809-34818 , 文章类型: Article,,卷期:2009年284-50]
- Several nascent peptides stall ribosomes during their own translation in both prokaryotes and eukaryotes. Leader peptides that induce stalling can regulate downstream gene expression. Interestingly, stalling peptides sho...
- GRASP65 and GRASP55 Sequentially Promote the Transport of C-terminal Valine-bearing Cargos to and through the Golgi Complex
[作者:D'Angelo, G; Prencipe, L; Iodice, L; Beznoussenko, G; Savarese, M; Marra, P; Di Tullio, G; Martire, G; De Matteis, MA; Bonatti, S,期刊:Journal of Biological Chemistry, 页码:34849-34860 , 文章类型: Article,,卷期:2009年284-50]
- The Golgi matrix proteins GRASP65 and GRASP55 have recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion whereas, surprisingly, they have be...
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